{"id":926,"date":"2023-08-03T11:34:29","date_gmt":"2023-08-03T02:34:29","guid":{"rendered":"https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome-test\/?p=926"},"modified":"2023-08-04T10:19:54","modified_gmt":"2023-08-04T01:19:54","slug":"%e7%ab%b9%e5%b3%b6-%e7%a7%80%e5%b9%b8%e3%80%80hideyuki-takeshima","status":"publish","type":"post","link":"https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/2023\/08\/03\/%e7%ab%b9%e5%b3%b6-%e7%a7%80%e5%b9%b8%e3%80%80hideyuki-takeshima\/","title":{"rendered":"\u7af9\u5cf6 \u79c0\u5e78\u3000Hideyuki Takeshima"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-1074\" src=\"https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome-test\/wp-content\/uploads\/sites\/15\/2023\/08\/Takeshimaphoto-300x200.jpeg\" alt=\"\" width=\"600\" height=\"400\" srcset=\"https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/wp-content\/uploads\/sites\/15\/2023\/08\/Takeshimaphoto-300x200.jpeg 300w, https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/wp-content\/uploads\/sites\/15\/2023\/08\/Takeshimaphoto-1024x683.jpeg 1024w, https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/wp-content\/uploads\/sites\/15\/2023\/08\/Takeshimaphoto-768x512.jpeg 768w, https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/wp-content\/uploads\/sites\/15\/2023\/08\/Takeshimaphoto-1536x1024.jpeg 1536w, https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/wp-content\/uploads\/sites\/15\/2023\/08\/Takeshimaphoto-2048x1365.jpeg 2048w, https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/wp-content\/uploads\/sites\/15\/2023\/08\/Takeshimaphoto-1200x800.jpeg 1200w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/p>\n<p class=\"paragraph\">\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u56e0\u5b50\u306e\u5236\u5fa1\u7570\u5e38\u306b\u7740\u76ee\u3057\u3066\u3001\u6162\u6027\u708e\u75c7\u306a\u3069\u306e\u74b0\u5883\u8981\u56e0\u304c\u30a8\u30d4\u30b2\u30ce\u30e0\u7570\u5e38\u3092\u8a98\u767a\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u6700\u8fd1\u306f\u3001\u30a8\u30d4\u30b2\u30ce\u30e0\u7570\u5e38\u3092\u304c\u3093\u6cbb\u7642\u306b\u5fdc\u7528\u3059\u308b\u305f\u3081\u306b\u3001\u7279\u5b9a\u907a\u4f1d\u5b50\u306e\u30a8\u30d4\u30b2\u30ce\u30e0\u7570\u5e38\u3092\u6301\u3064\u304c\u3093\u7d30\u80de\u7279\u7570\u7684\u306b\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u81ea\u5206\u306e\u5c02\u9580\u5206\u91ce\u306b\u8ef8\u8db3\u3092\u7f6e\u304d\u3064\u3064\u3001\u6700\u65b0\u306e\u7814\u7a76\u52d5\u5411\u306b\u3082\u30a2\u30f3\u30c6\u30ca\u3092\u306f\u308b\u3053\u3068\u3067\u3001\u30d6\u30ec\u30a4\u30af\u30b9\u30eb\u30fc\u306b\u3064\u306a\u304c\u308b\u3088\u3046\u306a\u7814\u7a76\u3092\u3057\u3066\u3044\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3><\/h3>\n<hr \/>\n<h3 class=\"h4 paragraph\">\u5c02\u9580\u5206\u91ce<\/h3>\n<p class=\"paragraph\">\u304c\u3093\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3001\u30a8\u30d4\u30b2\u30ce\u30e0\u89e3\u6790\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u95a2\u9023\u56e0\u5b50\u306e\u751f\u5316\u5b66<\/p>\n<h3 class=\"h4 paragraph\">\u4e3b\u8981\u8ad6\u6587<\/h3>\n<ol>\n<li><span class=\"character\">Takeshima H, Niwa T, Yamashita S, Takamura-Enya T, Iida N, Wakabayashi M, Nanjo S, Abe M, Sugiyama T, Kim YJ and Ushijima T. TET repression and increased DNMT activity synergistically induce aberrant DNA methylation. J Clin Invest, 130: 5370-5379, 2020. PMID:<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32663196\/\"><span class=\"character\">32663196<\/span><\/a><\/li>\n<li><span class=\"character\">Takeshima H, Yoda Y, Wakabayashi M, Hattori N, Yamashita S and Ushijima T. Low-dose DNA demethylating therapy induces reprogramming of diverse cancer-related pathways at the single-cell level. Clin Epigenetics, 12: 142, 2020. PMID:<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32958049\/\"><span class=\"character\">32958049<\/span><\/a><\/li>\n<li><span class=\"character\">Maeda M, Takeshima H, Iida N, Hattori N, Yamashita S, Moro H, Yasukawa Y, Nishiyama K, Hashimoto T, Sekine S, Ishii G, Ochiai A, Fukagawa T, Katai H, Sakai Y and Ushijima T. Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3. Gut, 69: 243-251, 2020. PMID:<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31085554\/\"><span class=\"character\">31085554<\/span><\/a><\/li>\n<\/ol>\n<p>\u25b6 <a href=\"https:\/\/researchmap.jp\/read0105996\/published_papers\"><span style=\"text-decoration: underline\">\u305d\u306e\u4ed6\u306e\u8ad6\u6587\u306f\u3053\u3061\u3089<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u56e0\u5b50\u306e\u5236\u5fa1\u7570\u5e38\u306b\u7740\u76ee\u3057\u3066\u3001\u6162\u6027\u708e\u75c7\u306a\u3069\u306e\u74b0\u5883\u8981\u56e0\u304c\u30a8\u30d4\u30b2\u30ce\u30e0\u7570\u5e38\u3092\u8a98\u767a\u3059\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u6700\u8fd1\u306f\u3001\u30a8\u30d4\u30b2\u30ce\u30e0\u7570\u5e38\u3092\u304c\u3093\u6cbb\u7642\u306b\u5fdc\u7528\u3059\u308b\u305f\u3081\u306b\u3001\u7279\u5b9a\u907a\u4f1d\u5b50\u306e\u30a8\u30d4\u30b2\u30ce\u30e0\u7570\u5e38\u3092\u6301\u3064\u304c\u3093\u7d30\u80de\u7279\u7570 &#8230;..<\/p>\n","protected":false},"author":26,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-926","post","type-post","status-publish","format-standard","hentry","category-free"],"acf":[],"_links":{"self":[{"href":"https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/wp-json\/wp\/v2\/posts\/926","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/wp-json\/wp\/v2\/users\/26"}],"replies":[{"embeddable":true,"href":"https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/wp-json\/wp\/v2\/comments?post=926"}],"version-history":[{"count":3,"href":"https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/wp-json\/wp\/v2\/posts\/926\/revisions"}],"predecessor-version":[{"id":928,"href":"https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/wp-json\/wp\/v2\/posts\/926\/revisions\/928"}],"wp:attachment":[{"href":"https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/wp-json\/wp\/v2\/media?parent=926"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/wp-json\/wp\/v2\/categories?post=926"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jupiter.hoshi.ac.jp\/lab\/epigenome\/wp-json\/wp\/v2\/tags?post=926"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}