研究論文

2010

· Efficient microwave-assisted prenylation of pinostrobin and biological evalution of its derivatives as antitumor agents. H. Poerwono, S. Sasaki, Y. Hattori, and K. Higashiyama Bioorg. Med. Chem. Lett., 20, 2086-2089 (2010)

· Dy(OTf)₃/Pybox-catalyzed enantioselective Friedel-Crafts alkylation of indoles with a,b-unsaturated trifluoromethyl ketones. S. Sasaki, T. Yamauchi, and K. Higashiyama Tetrahedron Lett., 51(17), 2326-2328 (2010)

2009

· Regio- and Stereoselective Ring-Opening Reaction of Chiral Aziridines: A Facile Synthesis of Chiral β-Amino Alcohols. K. Higashiyama, M. Matsumura, H. Kojima, T. Yamauchi Heterocycles 78(2), 471-485 (2009)

2008

· p-Dodecylaminophenol derived from the synthetic retinoid, fenretinide: antitumor efficacy in vitro and in vivo against human prostate cancer and mechanism of action. N. Takahashi, Y. Watanabe, Y. Maitani, T. Yamauchi, K. Higashiyama, and T. Ohba, Int. J. Cancer, 122, 689–698 (2008)

· Hydroxyethylated cationic cholesterol derivatives in liposome vectors promote gene expression in the lung. W. Ding, Y. Hattori, K. Higashiyama, Y. Maitani, Int. J. Pharm., 354 (1-2), 196-203 (2008)

· Changes in the rewarding effects induced by tramadol and its active metabolite M1 after sciatic nerve injury in mice. A. Nakamura, M. Narita, K. Miyoshi, K. Shindo, D. Okutsu, M. Suzuki, K. Higashiyama, T. Suzuki, Psychopharmacology, 200(3), 307-316 (2008)

· Concise Total Synthesis of (-)-Deoxocuscohygrine and (-)-Dihydrocuscohygrine. T. Yamauchi, S. Hagiwara, K. Higashiyama J. Org. Chem., 73 (24), 9784–9787 (2008)

2007

· Potent anticancer activities of novel aminophenol analogues against various cancer cell lines. T. Ohba, T. Yamauch, K. Higashiyama, and N. Takahashi, Bioorganic & Medicinal Chemistry, 15, (2), 847-853 (2007)

· Structure modification of andrographolide to improve its potency as anticancer. H. Powerono, Y. Hattori, H. Kubo, and K. Higashiyama, Indo. J. Chem., 7, (2), 202-207 (2007)

· Lack of development of behavioral sensitization to methylphenidate in mice: Correlation with reversible astrocytic activation. T. Suzuki, K. Shindo, M. Miyatake, K. Kurokawa, K. Higashiyama, M. Suzuki, and M. Narita, Eur. J. Pharmacol., 574, (1), 39-48 (2007)

2006

· Antioxidant and anticancer activities of novel p-alkylaminophenols and p-acylaminophenols (aminophenol analogues). N. Takahashi, T. Ohba, T. Yamauchi, and K. Higashiyama, Bioorganic & Medicinal Chemistry, 14, (17), 6089-6096 (2006).

· Hypoglycemic effects of multiflorine derivatives in normal mice. H. Kubo, M. Inoue J. Kamei, and K. Higashiyama, Biol. Pharm. Bull., 29, (10), 2046-50 (2006).

2005

· Folate-linked nanoparticles formed with DNA complexes in sodium chloride solution enhance transfection efficiency. Y. Hattori, H. Kubo, K. Higashiyama, and Y. Maitani, J. Biomed. Nanotech., 1,(2), 176-184 (2005)

· Diastereoselective Addition of Organolithiums to 1,3-Oxazolidines Complexed with Aluminum Tris(2,6-diphenylphenoxide) (ATPH). T. Yamauchi, H. Sazanami, Y. Sasaki, and K. Higashiyama, Tetrahedron, 61, (7), 1731-1736, (2005)

· Chemoselective Reduction of Ketones: Trifluoromethylketones Versus Methylketones. S. Sasaki, T. Yamauchi, H. Kubo, M. Kanai, A. Ishii, and K. Higashiyama, Tetrahedron Lett., 46, (9) 1497-1500, (2005)

· Implication of the Descending Dynorphinergic Neuron Projecting to the Spinal Cord in the (+)-Matrine- and (+)-Allomatrine-induced Antinociceptive Effects. K. Higashiyama, Y. Takeuci, T. Yamauchi, S. Imai, J. Kamei, Y. Yajim, M. Narita, T. Suzuki, Biol. Pharm. Bull., 28, (5), 845-848, (2005)

· Asymmetric synthesis of a-monofluoromethyl- and a-difluoromethylbenzylamines through regioselective hydrogenolysis. M. Kanai, K. Ueda, M. Yasumoto, Y. Kuriyama, K. Inomiya, T. Ootsuka, Y. Katsuhara, K. Higashiyama, and A. Ishii, Journal of Fluorine Chemistry, 126, (3), 377-383, (2005)

2004

· Practical Synthesis of Optically Active Fluorine-Substituted α-Phenylethylamines by Retardation　of Hydrogenolytic Cleavage at Benzylic Position. M. Kanai, M. Yasumoto, Y. Kuriyama, K. Inomiya, Y. Katsuhara, K. Higashiyama, and A., Ishii, Chem. Lett., 33, (11), 1424-1425 (2004)

· Mefenamic Acid: Analytical Profile. H. Poerwono, R. Widyowati, H. Kubo, K. Higashiyama, And G. Indrayanto, Profile Of Drug Substancs, Excipients And Related Methodology, 31, 281-336, (2004)

2003

• Effect of O-ethyl-3-butyl- cyclohexanol on the skin permeation of drugs with different physicochemical characteristics. C-J. Li, Y. Obata, K. Higashiyama, T. Nagai and K. Takayama, Int. J. Pharmaceut., 259, 193-198, (2003)
• High Throughput Analysis of Di(2-ethylhexyl)phthalate Metabolites in Urine for Exposure Assessment. K. Kato, T. Yamauchi, K. Higashiyama, and H. Nakazawa, J. Liq. Chromatogr. & Rel. Technol., 26, 2167-2176, (2003).
• Antinociceptive Effects of 6-Acyldecahydro[1,6]naphthyridine in Mice: Structure-Activity Relation Study of Matrine-Type Alkaloids Part III. S. Kobashi, M. Takizawa, H. Kubo, T. Yamauchi, and K. Higashiyama, Yakugakuzasshi, 123, 337-379 (2003).
• Highly Regioselective Hydrogenolysis of Bis(a-methylbenzyl)amine Derivatives Influenced by Trifluoromethyl Substituent on the Aromatic Ring: A Practical Asymmetric Synthesis of Trifluoromethyl Substituted 1-Phenylethylamines. M. Kanai, M, Yasumoto, Y. Kuriyama, K. Inomiya, A. Ishii, Y. Katsuhara, K. Higashiyama and K. Uneyama, Org. Lett., 5, (7) 1007-1010 (2003).
• Antinociceptive Effects of N-Acyloctahydropyrido[3,2,1-ij][1,6]naphthyridine in Mice: Structure-Activity Relation Study of Matrine-Type Alkaloids Part II. S. Kobashi, M. Takizawa, H. Kubo, T. Yamauchi, and K. Higashiyama, Biol. Pharm. Bull., 26, 375-379 (2003).

2002

• Antinociceptive Effects of 1-Acyl-4-dialkylaminopiperidine and 1-Alkyl-4-dialkylaminopiperidine in Mice: Structure-Activity Relation Study of Matrine-type Alkaloides. S. Kabashi, H. Kubo, T. Yamauchi and K. Higashiyama, Biol. Pharm. Bull., 25, (8) 1030-1034 (2002)
• Aryl Radical Cyclization of Chiral 3-Allyl-2-(2-bromophenyl)-1,3-oxazolidines with tributyltin hydride. T. Yamauchi, J. Sugiyama and K. Higashiyama, Heterocycles, 58, (22) 85-88(2002)
• Facile Asymmetric Synthesis of Aziridine Derivatives via the Diastereoselective Reaction of Chiral Imines with Dimethylsulfonium Methylide. K. Higashiyama, M. Matsumura, A.Shiogama, T.Yamauchi and S. Ohmiya, Heterocycles, 58, (22) 431-447(2002).
• Elevation of plasma levels of L-dopa in transdermal administration of L-dopa-butylester in rats. J. Sudo, H. Iwase, K. Higashiyama, K. Kakuno, F. Miyasaka, T. Meguro and K. Takayama, Durg Dev. Ind. Pharm., 28, (1) 59-65 (2002).
• Synthetic Route to 4,4,4-Trifluoro-3-hydroxybutyrate: Head-to-Tail and Head-to-Head Crystallizations through Double and Single Hydrogen Bonds of Hetero- and Homo-Chiral 4,4,4-Trifluoro-3-Hydroxybutyrophenones. A. Ishii, M. Kanai, K. Higashiyama and K. Mikami, Chirality, 14, (9) 709-712 (2002).

2001

• Citric Acid. Poerwono, H., Higashiyama, K., Kubo, H., Poernomo, A. T., Suharjono, Sudiana, I. K., Indrayanto, G. and Brittain H. G. Analytical Profiles of Drug Substances and Excipients, 28, 1-75(2001).
• Simultaneous Optimization Based on Artificial Neural Networks in Ketoprofen Hydrogel Formula Contaning O-Ethyl-3-butylcyclohexanol as Percutaneous Absorption Enhancer. Wu, P-C., Obata, Y., Fujikawa, M., Li, C-J., Higashiyama, K. and Takayama, K. J. Pharm. Sci., 90,(8), 1004-1014 (2001)
• Promoting Mechanism of Menthol Derivative, 1-O-Ethyl-3-buthylcyclohexanol, on the Percutaneous Absorption of Ketoprofen. Li, C-J., Higashiyama, K., Yoshimura, Y., Nagai, T., Takayama, K. and Obata, Y. Biol. Pharm. Bull., 24,(9), 1044-1048 (2001)
• Photosubstitution Reaction of Cyanoaromatics with Aliphatic Amides. M. Tsuji, K. Higashiyama, Y. Yamauchi, H. Kubo, S. Ohmiya, Heterocycles　54, (2), 1027-1032 (2001).
• Evaluation and structure-activity relationshio of synthesized cyclohexanol derivatives on percutaneous absorption of ketoprofen using artificial neural network. Y. Obata, C-J. Li, M. Fujikawa, K. Takayama, H. Sato, K. Higashiyama, K. Isowa, T. Nagai, Int. J. Pharmaceut., 212, (2), 223-231 (2001).

2000

• Synthesis of C2-symmetrical chiral diamines: diastereoselective addition to bis(1,3-oxazolidinyl)alkanes with Grignard reagents. T. Yamauchi, K. Higashiyama, H. Kubo, S. Ohmiya, Tetrahedron: Asymmetry 11, 3003-3015 (2000).
• Synthesis of C2-symmetrical chiral aromatic diamines by diastereoselective addition to bis(1,3-oxazolidinyl)aromatics
  with Grignard reagents. T. Yamauchi, K. Higashiyama, S. Ohmiya, Heterocycles　 53,(11), 2499-2508 (2000).
• Synthesis of (+)-Hupeol from (-)-Cytisine: Transformation of a Cyclic Imine to a Cyclic Hemiacetal. Y-Ho. Wang, K. Higashiyama, H. Kubo, J-S. Li, S. Ohmiya, Heterocycles, 53, (3), 545-548 (2000).
• Lupin Alkaloids from Chinese Maackia amurensis. Y-Ho. Wang, J-S Li, Z-R. Jiang, H. Kubo, K. Higashiyama, S. Ohmiya, Chem. Pharm. Bull., 48, (5), 641-645 (2000).
• Effect of synthesized cyclohexanone derivatives using l-menthol as a lead compound on the percutaneous absorption of ketoprofen. Y. Obata, H. Sato, C-J. Li, K. Takayama, K. Higashiyama, T. Nagai, K. Isowa, Int. J. Pharmaceut., 198, (2), 191-200 (2000).
• Purification and Identification of Antioxidant Substances in Human-Prlcenta Extracts. S. Togashi. N. Takahashi, Y. Kubo, A. Shigihara, K. Higashiyama, S. Watanabe, T. Fukui, J. Health. Sci., 4, (2), 117-125 (2000).
• The Hypoglycemic Effect of (7R,9aS)-7-Phenyloctahydroquinolizin-2-one in Mice.
  H. Kubo, J. Kobayashi, K. Higashiyama, J. Kamei, Y. Fujii, S. Ohmiya Biol. Pharm. Bull., 23, (9), 114-117 (2000).

1999

• A Lupin Alkaloide, (-)-Tenuamine (Norlusitanine), from Maackia Tenuifolia. Y-Ho. Wang, K. Higashiyama, H. Kubo, J-S. Li, S. Ohmiya Heterocycles, 51, (12), 3001-3004 (1999).
• Asymmetric synthesis of (+)- and (-)-dihydropinidines: diastereiselective addition to chiral imine or 1,3-oxazolidine
  derived from (R)-phenylglycinol as a single starting material with organometallic reagents. T. Yamauchi, H. Fujikura, K. Higashiyama, H. Takahashi, S. Ohmiya J. Chem. Soc. Perkin Trans 1, 2791-2794 (1999).
• Lupin Alkaloids from Chinese Maackia Hupehensis. Y-Ho. Wang, J-S Li, H. Kubo, K. Higashiyama, H. Komiya, S. Ohmiya Chem. Pharm. Bull., 47,1308-1310 (1999).
• (-)-14b-Acetoxymatrine and (+)-14a-Acetoxymatrine, Two New Matrine-Type Lupin Alkaloides from the Leaves of Sophora tonkinensis. P. Xiao, H. Kubo, H. Komiya, K. Higashiyama, Y.-N. Yan, J.-S. Li, S. Ohmiya Chem. Pharm. Bull., 47, 448-450 (1999).
• Kappa-opioid receptor-mediated antinociceptive effects of stereoisomers and derivatives of (+)-matrine in mice. P. Xiao, H. Kubo, M. Ohsawa, K. Higashiyama, H. Nagase, Y-N. Yan, J-S. Li, J. Kamei, S. Ohmiya Planta Med., 65, 230-233 (1999).
• Lupin Alkaloids from Seeds of Sophora Viciifolia. P. Xiao, H. Kubo, H. Komiya, K. Higashiyama, Y.-N. Yan, J.-S. Li, S. Ohmiya Pytochemistry, 50, 189-193 (1999).
• Thiomenthol Der ivatives as Novel Percutaneous Absorption Enhancers. Y. Takanashi, K. Higashiyama, H. Komiya, K. Takayama, T. Nagai Durg Dev. Ind. Pharm., 25, 89-94 (1999).

1998

• Stereocontrolled Preparation of cis- and trans-2,6-Dialkylpiperidines via Diastereoselective Reaction of 1-Aza-4-oxabicyclo[4.3.0]nonane Derivatives with Grignard Reagents. H. Poerwono, K. Higashiyama, T. Yamauchi, H. Kubo, S. Ohmiya, H. Takahashi Tetrahedron, 54, 13955-13970 (1998).
• Stereocontrolled Syntheses of Piperidine Derivatives Using Diastereoselective Reaction of Chiral 1,3-Oxazolidines with Grignard Reagents: Asymmetric Syntheses of the Pinidine Enantiomers. H. Poerwono, K. Higashiyama, H. Takahashi J. Org. Chem., 63 (8), 2711-2714 (1998).
• Stereocontrolled Addition of Grignard Reagents to Chiral 1,3-Oxazolidines having N-Methoxybenzyl Groups: Effect of N-Substituent in Diastereoselectivity. T. Yamauchi, H. Takahashi, K. Higashiyama Heterocycles, 48,1813-1823 (1998).
• Stereocontrol at the Quaternary Center in 1-Substituted 1-Phenyl-2,2,2-Trifluoroethylamines: Stereospecific Substitution
  with Retention of a Chiral Cyclic Fluoral N,O-acetal with Organolithium Reagents. A. Ishii, F. Miyamoto, K. Higashiyama, K. Mikami Tetrahedron Lett., 39, 1199-1202 (1998).
• Facile in situ Preparation of o-Azaxylylene from N,O-Diethoxycarbonyl-o-aminobenzylalcohol. K. Nishiyama, H. Kubo, T. Sato, K. Higashiyama, S. Ohmiya Heterocycles, 48, 1103-1106 (1998).
• Diastereoselective Addition of Silyl Enol Ether to Chiral Imines and 1,3-Oxazolidines Using a Lewis Acid. K. Higashiyama, H. Kyo, H. Takahashi Synlet., (5), 489-490 (1998).
• Diastereoselective Addition of Grignard Reagents to Chiral 1,3-Oxazolodines Having aN-Diphenylmethyl Substituent. T.Yamauchi, H. Takahashi, K. Higashiyama, Chem. Pharm. Bull., 46 (3), 384-389 (1998).
• An Applied Stereocontrolled Synthesis of Piperidine Derivative Utilizing Diastereoselective Reaction of Chiral 1,3-Oxazolidine with Grignard Reagent; Asymmetric Synthesis of an Alkaloid, (-)-Sedamine. H. Poerwono, K. Higashiyama, H. Takahashi Heterocycles, 47, 263-270 (1998).
• (+)-Hupeol, a Possible Non-basic Metabolite of the Lupine Alkaloid (-)-Cytisine in Chinese Maackia hupehensis. Y-Ho. Wang, H. Kubo, K. Higashiyama, H. Komiya, J-S. Li, S. Ohmiya J. Chem. Research (S). 196-197 (1998).
• Stereospecific Reduction with Retention of Chiral Fluoral-derived 1,3-Oxazolidines with LiAlH4: Asymmetric Synthesis of 1-Substituted 2,2,2-Trifluoroethylamines. A. Ishii, F. Miyamoto, K. Higashiyama, K. Mikami Chem. Lett., 119-120 (1998).