†Equal contribution, *Correspondence
2025年
Makabe H, Hamada Y, Narita M, Tanaka K, Takise J, Tatezuki R, Kawamura N, Suda Y, Shimizu T, Kuzumaki N*, Narita M*. Usefulness of zoledronic acid for the aggravated bone cancer and bone cancer pain. PAIN Research 40:43-53(2025)
成田 年. 腫瘍神経科学の理解の重要性：神経からがん治療を考える時代の到来. JAPIC NEWS 494:4-5 (2025)
2024年
Suda Y†, Nakamura K†, Matsuyama F, Hamada Y, Makabe H, Narita M, Nagumo Y, Mori T, Kuzumaki N*, Narita M*. Peripheral-central network analysis of cancer cachexia status accompanied by the polarization of hypothalamic microglia with low expression of inhibitory immune checkpoint receptors. Mol Brain 17:20 (2024)
Sugawara H†, Date A†, Fuke S, Nakachi Y, Kato T, Narita M, Bundo M*, Iwamoto K*. Quantification of cytosine modifications in the aged mouse brain. Neuropsychopharmacol Rep 44:250-255 (2024)
濱田 祐輔、岡本 悠、葛巻直子、成田 年. 痛みと脳内報酬系の変容: 中脳辺縁ドパミン神経系の機能変容に着目した痛覚・情動制御機構. 臨床と研究 101:660-664 (2024)
成田 年. 疼痛病態生理の包括的理解と疼痛制御の重要性. メディカル・サイエンス・ダイジェスト 50:407-409 (2024)
南雲 康行、田中 謙一、葛巻 直子、成田 年. Pain Oncologyからみるがん患者のがん性疼痛管理の重要性. メディカル・サイエンス・ダイジェスト 50:426-428 (2024)
南雲康行、濱田祐輔、葛巻直子、成田 年. 慢性疼痛による脳可塑性が導く睡眠障害の発症とその分子機序: 持続痛による悪性サイクルの理解. ペインクリニック 45: 161-169 (2024)
2023年
Kawamura Y*, Oka K, Semba T, Takamori M, Sugiura Y, Yamasaki R, Suzuki Y, Chujo T, Nagase M, Oiwa Y, Fujioka S, Homma S, Yamamura Y, Miyawaki S, Narita M, Fukuda T, Sakai Y, Ishimoto T, Tomizawa K, Suematsu M, Yamamoto T, Bono H, Okano H, Miura K*. Cellular senescence induction leads to progressive cell death via the INK4a-RB pathway in naked mole-rats. EMBO J 42(16):e111133 (2023)
Tanaka K, Kuzumaki N, Hamada Y, Suda Y, Mori T, Nagumo Y, Narita M*. Elucidation of the mechanisms of exercise-induced hypoalgesia and pain prolongation due to physical stress and the restriction of movement. Neurobiol Pain 14:100133 (2023)
Yoshida S, Hamada Y, Narita M, Sato D, Tanaka K, Mori T, Tezuka H, Suda Y, Tamura H, Aoki K, Kuzumaki N*, Narita M*. Elucidation of the mechanisms underlying tumor aggravation by the activation of stress-related neurons in the paraventricular nucleus of the hypothalamus. Mol Brain 16:18 (2023)
Tanaka K, Kondo T, Narita M, Muta T, Yoshida S, Sato D, Suda Y, Hamada Y, Shimizu T, Kuzumaki N*, Narita M*. Cancer aggravation due to persistent pain signals with the increased expression of pain-related mediators in sensory neurons of tumor-bearing mice. Mol Brain 16:19 (2023)
Tanaka K, Kondo T, Narita M, Muta T, Yoshida S, Sato D, Suda Y, Hamada Y, Tezuka H, Kuzumaki N*, Narita M*. Repeated activation of Trpv1-positive sensory neurons facilitates tumor growth associated with changes in tumor-infiltrating immune cells. Biochem Biophys Res Commun 648:36-43 (2023)
Yoshida S†, Tanaka K†, Narita M, Yamabe Y, Mori T, Hamada Y, Suda Y, Kuzumaki N*, Narita M*. Repeated activation of corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus prolongs postsurgical pain. Jpn J Pharm Palliat Care Sci 16:31-37 (2023)
2022年
Gondoh E†, Hamada Y†, Mori T, Iwazawa Y, Shinohara A, Narita M, Sato D, Tezuka H, Yamauchi T, Tsujimura M, Yoshida S, Tanaka K, Yamashita K, Akatori H, Higashiyama K, Arakawa K, Suda Y, Miyano K, Iseki M, Inada E, Kuzumaki N*, Narita M*. Possible mechanism for improving the endogenous immune system through the blockade of peripheral μ-opioid receptors by treatment with naldemedine. Br J Cancer 127:1565-1574 (2022)
Suzuki H, Mitsunaga S*, Ikeda M, Aoyama T, Yoshizawa K, Yamaguchi M, Suzuki M, Narita M, Kawasaki T, Ochiai A. Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer. Cancer Med 11:5001-5012 (2022)
Sato D, Hamada Y, Narita M, Mori T, Tezuka H, Suda Y, Tanaka K, Yoshida S, Tamura H, Yamanaka A, Senba E, Kuzumaki N*, Narita M*. Tumor suppression and improvement in immune systems by specific activation of dopamine D1-receptor-expressing neurons in the nucleus accumbens. Mol Brain 15:17 (2022)
Sato D, Narita M, Hamada Y, Mori T, Tanaka K, Tamura H, Yamanaka A, Matsui R, Watanabe D, Suda Y, Senba E, Watanabe M, Navratilova E, Porreca F, Kuzumaki N*, Narita M*. Relief of neuropathic pain by cell-specific manipulation of nucleus accumbens dopamine D1- and D2-receptor-expressing neurons. Mol Brain 15:10 (2022)
Takemura Y, Sudo Y, Saeki T, Kurata S, Suzuki T, Mori T*, Uezono Y*. Involvement of spinal G-protein inwardly rectifying potassium (GIRK) channels in the enhanced antinociceptive effects of the activation of both μ-opioid and cannabinoid CB1 receptors. J Pharmacol Sci 149:85-92 (2022)
Mori T*, Yamashita K, Takahashi K, Mano S, Sato D, Narita M*. Characterization of the discriminative stimulus effect of quinpirole: Further evidence for functional interaction between central dopamine D1/D2-receptors. Pharmacol Biochem Behav 213:173314 (2022)
葛巻直子、成田年. µオピオイド受容体とがん病態, LiSA 29:195-200 (2022)
田中謙一、成田年. 痛みの遷延化機構における中枢神経変容：疼痛治療における“メンタルケア”の重要性. 臨床精神薬理 25:471-476 (2022)
2021年
Katsuda Y†, Tanaka K†, Mori T, Narita M, Takeshima H, Kondo T, Yamabe Y, Matsufuji M, Sato D, Hamada Y, Yamaguchi K, Ushijima T, Inada E, Kuzumaki N*, Iseki M*, Narita M*. Histone modification of pain-related gene expression in spinal cord neurons under a persistent postsurgical pain-like state by electrocautery. Mol Brain 14:146 (2021)
Suda Y†, Nakashima T†, Matsumoto H, Sato D, Nagano S, Mikata H, Yoshida S, Tanaka K, Hamada Y, Kuzumaki N*, Narita M*. Normal aging induces PD-1-enriched exhausted microglia and A1-like reactive astrocytes in the hypothalamus. Biochem Biophys Res Commun 541:22-29 (2021)
Setsu T†, Hamada Y†, Oikawa D, Mori T, Ishiuji Y, Sato D, Narita M, Miyazaki S, Furuta E, Suda Y, Sakai H, Ochiya T, Tezuka H, Iseki M, Inada E, Yamanaka A, Kuzumaki N*, Narita M*. Direct evidence that the brain reward system is involved in the control of scratching behaviors induced by acute and chronic itch. Biochem Biophys Res Commun 534:624-631 (2021)
Takemura Y†*, Iwase Y†, Hamada Y†, Narita M, Yamashita K, Nakahama M, Suda Y, Miyano K, Yamazaki M, Kuzumaki N, Mori T*, Narita M*. Pharmacological analysis of hydromorphone acting as a β-arrestin-nonpreferred strong μ-opioid receptor ligand. Jpn J Pharm Palliat Care Sci 14:83-89 (2021)
Miyano K†, Yoshida Y†, Hirayama S, Takahashi H, Ono H, Meguro Y, Manabe S, Komatsu A, Nonaka M, Mizuguchi T, Fujii H, Higami Y, Narita M, Uezono Y*. Oxytocin is a positive allosteric modulator of κ-opioid receptors but not δ-opioid receptors in the G protein signaling pathway. Cells 10:2651 (2021)
Mori T†, Takemura Y†, Arima T, Iwase Y, Narita M, Miyano K, Hamada Y, Suda Y, Matsuzawa A, Sugita K, Matsumura S, Sasaki S, Yamauchi T, Higashiyama K, Uezono Y, Yamazaki M, Kuzumaki N*, Narita M*. Further investigation of the rapid-onset and short-duration action of the G protein-biased μ-ligand oliceridine. Biochem Biophys Res Commun 534:988-994 (2021)
成田 年、濱田祐輔、須田雪明、宮野加奈子、成田道子、葛巻直子. 痛みを深く理解する−痛みによる免疫コントロールシステムへの影響. 月刊薬事 63:19-24 (2021)
2020年
Kondo T, Hamada Y, Sato D, Tanaka K, Yamabe Y, Narita M, Yoshida S, Kagawa R, Mizuno T, Iizuka M, Shimizu H, Yamashita K, Mori T, Yamanaka A, Kuzumaki N, Narita M*. Conditional activation of peripheral sensory nerves induces an aversive state with the down-regulation of neural functions of the nucleus accumbens. Jpn J Pharm Palliat Care Sci 13:1-8 (2020)
Onodera K, Shimojo D, Ishihara Y, Yano M, Miya F, Banno H, Kuzumaki N, Ito T, Okada R, de Araújo Herculano B, Ohyama M, Yoshida M, Tsunoda T, Katsuno M, Doyu M, Sobue G, Okano H, Okada Y*. Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs. Mol Brain 13:18 (2020)
Miyano K, Manabe S, Komatsu A, Fujii Y, Mizobuchi Y, Uezono E, Ohshima K, Nonaka M, Kuroda Y, Narita M, Fujii H, Uezono Y*. The G Protein Signal-Biased Compound TRV130; Structures, Its Site of Action and Clinical Studies. Curr Top Med Chem 20:2822-2829 (2020)
濱田祐輔、成田 年. がん・免疫における痛みの新たな役割. 実験医学 38:396-400 (2020)
成田 年、濱田祐輔、田中謙一、須田雪明、宮野加奈子、葛巻直子. 遷延化術後痛におけるエピジェネティクス修飾機構. ペインクリニック 41:1590-1598 (2020)
濱田祐輔、渡邉 萌、成田道子、葛巻直子、成田 年. 慢性疼痛下における脳内報酬系の破綻の分子メカニズム. ペインクリニック 41:S26-S34 (2020)
田中謙一、葛巻直子、成田年. 慢性疼痛におけるエピジェネティック変容の解析. 医学のあゆみ 272:61-66 (2020)
葛巻直子、濱田祐輔、田中謙一、須田雪明、成田 年. 基礎研究からみた術後疼痛管理の重要性, ペインクリニック 41:74-82 (2020)
吉田小莉、濱田祐輔、葛巻直子、成田 年. 鎮痛薬研究の最近の進歩. 臨床と研究 97:217-222 (2020)
葛巻直子、濱田祐輔、須田雪明、成田 年. 医療用麻薬の鎮痛の作用機序. Clinical neuroscience 38:961-965 (2020)
芝崎真裕、森 友久、成田 年. ベンゾジアゼピン受容体作動薬依存の薬理学的機序. 精神医学 62:387-394 (2020)
2019年
Kuzumaki N†*, Suda Y†, Iwasawa C, Narita M, Sone T, Watanabe M, Maekawa A, Matsumoto T, Akamatsu W, Igarashi K, Tamura H, Takeshima H, Tawfik VL, Ushijima T, Hattori N, Okano H*, Narita M*. Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson’s disease. Brain 142:1675-1686 (2019)
Iwasawa C, Kuzumaki N*, Suda Y, Kagawa R, Oka Y, Hattori N, Okano H*, Narita M*. Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations. Mol Brain 12:5 (2019)
Sugiyama E, Kondo T, Kuzumaki N, Honda K, Yamanaka A, Narita M, Suematsu M, Sugiura Y*. Mechanical allodynia induced by optogenetic sensory nerve excitation activates dopamine signaling and metabolism in medial nucleus accumbens. Neurochem Int 129:104494 (2019)
Iwasawa C, Narita M, Tamura H*. Regional and temporal regulation and role of somatostatin receptor subtypes in the mouse brain following systemic kainate-induced acute seizures. Neurosci Res 149:38-49 (2019)
Han C*, Kawata M, Hamada Y, Kondo T, Wada J, Asano K, Makabe H, Igarashi K, Kuzumaki N, Narita M, Kobayashi H, Narita M*. Analyses of the possible anti-tumor effect of Yokukansan. J Nat Med 73:468-479 (2019)
Iwasawa C, Tamura R, Sugiura Y, Suzuki S, Kuzumaki N, Narita M, Suematsu M, Nakamura M, Yoshida K, Toda M, Okano H*, Miyoshi H*. Increased Cytotoxicity of Herpes Simplex Virus Thymidine Kinase Expression in Human Induced Pluripotent Stem Cells. Int J Mol Sci 20:E810 (2019)
Tamura R, Miyoshi H*, Sampetrean O, Shinozaki M, Morimoto Y, Iwasawa C, Fukaya R, Mine Y, Masuda H, Maruyama T, Narita M, Saya H, Yoshida K, Okano H, Toda M*. Visualization of spatiotemporal dynamics of human glioma stem cell invasion. Mol Brain 12, 45 (2019)
Sakai H*, Kimura M, Tsukimura Y, Yabe S, Isa Y, Kai Y, Sato F, Kon R, Ikarashi N, Narita M, Chiba Y, Kamei J. Dexamethasone exacerbates cisplatin-induced muscle atrophy. Clin Exp Pharmacol Physiol 46:19-28 (2019)
濱田祐輔、成田 年. 知覚神経と免疫細胞のクロストーク. ペインクリニック 40:57-65 (2019)
佐藤大介、渡邉萌、葛巻直子、成田年. 痛みの基礎 -痛みの伝達と脳受容-. ペインクリニック 40:S257-S265 (2019)
2018年
Watanabe M†, Sugiura Y†, Sugiyama E, Narita M, Navratilova E, Kondo T, Uchiyama N, Yamanaka A, Kuzumaki N, Porreca F, Narita M*. Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: analysis using a microdialysis/mass spectrometry integrated system. Mol pain 14:1744806918754934 (2018)
Watanabe M, Narita M, Hamada Y, Yamashita A, Tamura H, Ikegami D, Kondo T, Shinzato T, Shimizu T, Fukuchi Y, Muto A, Okano H, Yamanaka A, Tawfik VL, Kuzumaki N, Navratilova E, Porreca F, Narita M*. Activation of VTA dopaminergic neurons reverses pathological allodynia resulting from nerve-injury or bone cancer. Mol Pain 14:1744806918756406 (2018)
Suda Y†, Kuzumaki N†*, Sone T, Narita M, Tanaka K, Hamada Y, Iwasawa C, Shibasaki M, Maekawa A, Matsuo M, Akamatsu W, Hattori N, Okano H*, Narita M*. Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson’s disease-like motor dysfunction. Mol Brain 11:6 (2018)
Suda Y†, Kuzumaki N†*, Narita M, Hamada Y, Shibasaki M, Tanaka K, Tamura H, Kawamura T, Kondo T, Yamanaka A, Narita M*. Effect of ghrelin on the motor deficit caused by the ablation of nigrostriatal dopaminergic cells or the inhibition of striatal dopamine receptors. Biochem Biophys Res Commun 496:1102-1108 (2018)
Neyama H, Hamada Y, Tsukahara R, Narita M, Tsukamoto K, Ueda H*. Blockade of analgesic effects following systemic administration of N-methyl-kyotorphin, NMYR and arginine in mice deficient of preproenkephalin or proopiomelanocortin gene. Peptides 107:10-16 (2018)
Meguro Y, Miyano K, Hirayama S, Yoshida Y, Ishibashi N, Ogino T, Fujii Y, Manabe S, Eto M, Nonaka M, Fujii H, Ueta Y, Narita M, Sata N, Yada T, Uezono Y*. Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator. J Pharmacol Sci 137:67-75 (2018)
Sakai H*, Yabe S, Sato K, Kai Y, Sato F, Yumoto T, Inoue Y, Narita M, Matsumoto K, Kato S, Chiba Y. ELR+ chemokine-mediated neutrophil recruitment is involved in 2,4,6-trinitrochlorobenzene-induced contact hypersensitivity. Clin Exp Pharmacol Physiol 45:27-28 (2018)
2017年
Hamada Y, Tasaki Y, Morita K, Yamamizu K, Narita M, Matsuyama F, Suzuki M, Ikegami D, Arakawa K, Nagumo Y, Kawata M, Uezono Y, Nagase H, Aoki K, Yamashita JK, Kuzumaki N, Narita M*. The κ-opioid receptor agonist nalfurafine enhances the chemotherapy-induced survival advantage in pancreatic cancer-bearing mice. Jpn J Pharm Palliat Care Sci 10:7-12 (2017)
Narita M, Shimura E, Nagasawa A, Aiuchi T, Suda Y, Hamada Y, Ikegami D, Iwasawa C, Arakawa K, Igarashi K, Kuzumaki N, Yoshioka Y, Ochiya T, Takeshima H, Ushijima T, Narita M*. Epigenetic mechanisms of the gefitinib-induced epithelial-to-mesenchymal transition in non-small-cell lung cancer cells. PLoS One e0172115 (2017)
Mori T†, Kuzumaki N†, Arima T, Narita M, Tateishi R, Kondo T, Hamada Y, Kuwata H, Kawata M, Yamazaki M, Sugita K, Matsuzawa A, Baba K, Yamauchi T, Higashiyama K, Nonaka M, Miyano K, Uezono Y, Narita M*. Usefulness for the combination of G-protein- and β-arrestin-biased ligands of μ-opioid receptors: Prevention of antinociceptive tolerance. Mol Pain 13:1744806917740030 (2017)
Sagara A,Karasawa T, Igarashi K, Otsuka M, Sugiura R, Kodama A, Yamashita M, Narita M, Kato Y*. Controlled Secretion of the Anticancer Protein MDA-7 from Engineered Mesenchymal Stem Cells. Biol Pharm Bull 40:113-117 (2017)
Sagara A, Igarashi K, Otsuka M, Kodama A, Yamashita M, Sugiura R, Karasawa T, Arakawa K, Narita M, Kuzumaki N, Narita M, Kato Y*. Endocan as a prognostic biomarker of triple-negative breast cancer. Breast Cancer Res Treat 161:269-278 (2017)
Morikawa S, Ikegaya Y, Narita M, Tamura H*. Activation of perineuronal netexpressing excitatory neurons during associative memory encoding and retrieval. Sci Rep 7:46024 (2017)
Sakai H*, Sato K, Sato F, Kai Y, Mandokoro K, Matsumoto K, Kato S, Yumoto T, Narita M, Chiba Y. Curcumin inhibits epigen and amphiregulin upregulated by 2,4,6-trinitrochlorobenzene associated with attenuation of skin swelling. Inflamm Res 66:663-678 (2017)
Sakai H*, Kimura M, Isa Y, Yabe S, Maruyama A, Tsuruno Y, Kai Y, Sato F, Yumoto T, Chiba Y, Narita M. Effect of acute treadmill exercise on cisplatin-induced muscle atrophy in the mouse. Pflugers Arch 469:1495-1505 (2017)
Sakai H*, Tabata S, Kimura M, Yabe S, Isa Y, Kai Y, Sato F, Yumoto T, Miyano K, Narita M, Uezono Y. Active ingredients of Hange-shashin-to, Baicalelin and 6-Gingerol, Inhibit 5-Fluorouracil-Induced Upregulation of CXCL1 in the Colon to Attenuate Diarrhea Development. Biol Pharm Bull 40:2134-2139 (2017)
2016年
Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, Koya I, Okada Y, Kimura T, Tsuchiya Y, Suzuki S, Ohishi N, kuzumaki N, Matsuzaki Y, Narita M, Ikeda E, Okanoya K, Seino K, Saya H, Okano H*, Miura K*. Tumour resistance in induced pluripotent stem cells derived from naked mole-rats. Nat Commun 7:11471 (2016)
Wakaizumi K, Kondo T, Hamada Y, Narita M, Kawabe R, Narita H, Watanabe M, Kato S, Senba E, Kobayashi K, Kuzumaki N, Yamanaka A, Morisaki H, Narita M*. Involvement of mesolimbic dopaminergic network in neuropathic pain relief by treadmill exercise: A study for specific neural control with Gi-DREADD in mice. Mol Pain 12:1744806916681567 (2016)
Hori N, Narita M, Yamashita A, Horiuchi H, Hamada Y, Kondo T, Watanabe M, Igarashi K, Kawata M, Shibasaki M, Yamazaki M, Kuzumaki N, Inada E, Ochiya T, Iseki M, Mori T, Narita M*. Changes in the expression of IL-6-mediated microRNAs in the dorsal root ganglion under neuropathic pain in mice. Synapse 70:317-24 (2016)
Doi S, Mori T*, Uzawa N, Arima T, Takahashi T, Uchida M, Yawata A, Narita M, Uezono Y, Suzuki T, Narita M*. Characterization of methadone as a β-arrestin-biased μ-opioid receptor agonist. Mol Pain 12:1744806916654146 (2016)
Sagara A, Igarashi K, Otsuka M, Karasawa T, Gotoh N, Narita M, Kuzumaki N, Narita M*, Kato Y*. Intrinsic resistance to 5-fluorouracil in a brain metastatic variant of human breast cancer cell line, MDA-MB-231BR. PLoS One 11:e0164250 (2016)
Sakai H*, Sato K, Kai Y, Chiba Y, Narita M. Denatonium and 6-n-propyl-2-thiouracil, agonists of bitter taste receptor, inhibit contraction of various types of smooth muscles in the rat and mouse. Biol Pharm Bull 39:33-41 (2016)
Sakai H*, Kai Y, Takase K, Sato K, Kimura M, Tabata S, Yaegashi M, Sato F, Yomoto T, Narita M. Role of peptide YY in 5-fluorouracil-induced reduction of dietary intake. Clin Exp Pharmacol Physiol 43:753-759 (2016)
Sakai H*, Kai Y, Oguchi A, Kimura M, Tabata S, Yaegashi M, Saito T, Sato K, Sato F, Yumoto T, Narita M. Curcumin Inhibits 5-Fluorouracil-induced Up-regulation of CXCL1 and CXCL2 of the Colon Associated with Attenuation of Diarrhoea Development. Basic Clin Pharmacol Toxicol 110:540-547 (2016)
Ochiai W†, Kaneta M†, Nagae M, Yuzuhara A, Li X, Suzuki H, Hanagata M, Kitaoka S, Kusunoki Y, Kon R, Miyashita K, Masukawa D, Ikarashi N, Narita M, Suzuki T, Sugiyama K*. Mice with neuropathic pain exhibit morphine tolerance due to a decrease in the morphine concentration in the brain. Eur J Pharm Sci 92:298-304 (2016)
2015年
Descalzi G, Ikegami D, Ushijima T, Nestler EJ, Zachariou V*, Narita M*. Epigenetic mechanisms of chronic pain. Trends Neurosci 38:237-246 (2015)
Yamamizu K*, Hamada Y, Narita M. κ Opioid systems regulate angiogenesis in development and tumors. Br J Pharmacol 172:268-276 (2015)
Koh K, Hamada A, Hamada Y, Yanase M, Sakaki M, Someya K, Narita M, Kuzumaki N, Ikegami D, Sakai H, Iseki M, Inada E, Narita M*. Possible involvement of activated locus coeruleus-noradrenergic neurons in pain-related sleep disorders. Neurosci lett 589:200-206 (2015)
Suzuki M†, Chiwaki F†, Sawada Y, Ashikawa M, Aoyagi K, Fujita T, Yanagihara K, Komatsu M, Narita M, Suzuki T, Nagase H, Kushima R, Sakamoto H, Fukagawa T, Katai H, Nakagama H, Yoshida T, Uezono Y*, Sasaki H*. Peripheral opioid antabonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo. PLoS One 10:e0123407 (2015)
Saisu H, Igarashi K, Narita M, Ikegami D, KuzumakiN, WajimaK, Nakagawa T, Narita M*. Neuropathic pain-like stimuli change the expression of ribosomal proteins in the amygdala: genome-wide search for a “pain-associated anxiety-related factor”. J Pharm Palliat Care Sci 8:47-57 (2015)
Juliandi B†, Tanemura K†, Igarashi K, Tominaga T, Furukawa Y, Otsuka M, Moriyama N, Ikegami D, Abematsu M, Sanosaka T, Tsujimura K, Narita M, Kanno J, Nakashima K*. Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid. Stem Cell Reports 5:1-14 (2015)
2014年
Yamashita A, Hamada A, Suhara Y, Kawabe R, Yanase M, Kuzumaki N, Narita M, Matsui R, Okano H, Narita M*. Astrocytic activation in the anterior cingulate cortex is critical for sleep disorder under neuropathic pain. Synapse 68:235-247 (2014)
Odo M, Koh K, Takada T, Yamashita A, Narita M, Kuzumaki N, Ikegami D, Sakai H, Iseki M, Inada E, Narita M*. Changes in circadian rhythm for mRNA expression of melatonin 1A and 1B receptors in the hypothalamus under a neuropathic pain-like state. Synapse 68:253-258 (2014)
Matsumoto K*, Narita M, Muramatsu N, Nakayama T, Misawa K, Kitajima M, Tashima K, Devi LA, Suzuki T, Takayama H, Horie S. Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice. J Pharmacol Exp Ther 348:383-92 (2014)
Sakai H*, Sagara A, Arakawa K, Sugiyama R, Hirosaki A, Takase K, Jo A, Sato K, Chiba Y, Yamazaki M, Matoba M, Narita M*. Mechanisms of cisplatin-induced muscle atrophy. Toxicol Appl Pharmacol 278:190-199 (2014)
Sakai H*, Sagara A, Matsumoto K, Jo A, Hirosaki A, Takase K, Sugiyama R, Sato K, Ikegami D, Horie S, Matoba M, Narita M*. Neutrophil recruitment is critical for 5-fluorouracil-induced diarrhea and the decrease in aquaporins in the colon. Pharmacol Res 87:71-79 (2014)
Sakai H*, Sato K, Takase K, Hirosaki A, Jo A, Sugiyama R, Chiba Y, Narita M*. The gene expression of aquaporins in various cutaneous tissues of the mouse. J Exp Integr Med 4:75-79. (2014)
Sakai H*, Watanabe A, Fujita A, Misawa M, Narita M, Chiba Y. Augmented bronchial smooth muscle contractility induced by aqueous cigarette smoke extract in rats. J Smooth Muscle Res 50:39-47 (2014)
Sakai H*, Sato K, Kai Y, Shoji T, Hasegawa S, Nishizaki M, Sagara A, Yamashita A, Narita M. Distribution of aquaporin genes and selection of individual reference genes for quantitative real-time RT-PCR analysis in multiple tissues of the mouse. Can J Physiol Pharmacol 92:789-796 (2014)
Zhao M, Nakamura S, Miyake T, So K, Shirakawa H, Tokuyama S, Narita M, Nakagawa T*, Kaneko S. Pharmacological characterization of standard analgesics on oxaliplatin-induced acute cold hypersensitivity in mice. J Pharmacol Sci 124:514-517 (2014)
Kobori T, Fujiwara S, Miyagi K, Harada S, Nakamoto K, Nakagawa T, Takahashi H, Narita M, Tokuyama*. Involvement of Moesin in the Development of Morphine Analgesic Tolerance through P-glycoprotein at the Blood-Brain Barrier. Drug Metab Pharmacokinet 29:482-489 (2014)
2013年
Imai S, Ikegami D, Yamashita A, Shimizu T, Narita M, Niikura K, Furuya M, Kobayashi Y, Miyashita K, Okutsu D, Kato A, Nakamura A, Araki A, Omi K, Nakamura M, James Okano H, Okano H, Ando T, Takeshima H, Ushijima T, Kuzumaki N, Suzuki T, Narita M*. Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain. Brain 136:828-843 (2013)
Ito H, Yanase M, Yamashita A, Kitabatake C, Hamada A, Suhara Y, Narita M, Ikegami D, Sakai H, Yamazaki M, Narita M*. Analysis of sleep disorders under pain using an optogenetic tool: possible involvement of the activation of dorsal raphe nucleus-serotonergic neurons. Mol Brain 6:59 (2013)
Yamamizu K†*, Furuta S†, Hamada Y, Yamashita A, Kuzumaki N, Narita M, Doi K, Katayama S, Nagase H, Yamashita JK, Narita M*. κ Opioids inhibit tumor angiogenesis by suppressing VEGF signaling. Sci Rep 3:3213 (2013)
Takada T, Yamashita A, Date A, Yanase M, Suhara Y, Hamada A, Sakai H, Ikegami D, Iseki M, Inada E, Narita M*. Changes in the circadian rhythm of mRNA expression for µ-opioid receptors in the periaqueductal gray under a neuropathic pain-like state. Synapse 67:216-223 (2013)
Nakamura A, Hasegawa M, Minami K, Kanbara T, Tomii T, Nishiyori A, Narita M, Suzuki T, Kato A*. Differential activation of the u-opioid receptor by oxycodone and morphine in pain-related brain regions in a bone cancer pain model. Br J Pharmacol 168:375-388 (2013)
Narita M*, Imai S, Nakamura A, Ozeki A, Asato M, Rahmadi M, Sudo Y, Hojo M, Uezono Y, Devi LA, Kuzumaki N, Suzuki T*. Possible involvement of prolonging spinal μ-opioid receptor desensitization in the development of antihyperalgesic tolerance to μ-opioids under a neuropathic pain-like state. Addict Biol 18:614-622 (2013)
Yoshizawa K†, Mori T†*, Ueno T, Nishiwaki M, Shibasaki M, Shimizu N, Narita M, Suzuki T*. Involvement of serotonin receptor mechanisms in the discriminative stimulus effects of ketamine in rats. J Pharmacol Sci 121:237-241. (2013)
Sakai H*, Sagara A, Matsumoto K, Hasegawa S, Sato K, Nishizaki M, Shoji T, Horie S, Nakagawa T, Tokuyama S, Narita M*. 5-Fluorouracil induces diarrhea with changes in the expression of inflammatory cytokines and aquaporins in mouse intestines. PLoS One 8:e54788 (2013)
Shibasaki M, Watanabe K, Takeda K, Itoh T, Tsuyuki T, Narita M, Mori T, Suzuki T*. Effect of chronic ethanol treatment on μ-opioid receptor function, interacting proteins and morphine-induced place preference. Psychopharmacology 228:207-15 (2013)
Matsumoto K*, Nakajima T, Sakai H, Kato S, Sagara A, Arakawa K, Tashima K, Narita M, Horie S. Increased Expression of 5-HT3 and NK 1 Receptors in 5-Fluorouracil-Induced Mucositis in Mouse Jejunum. Dig Dis Sci 58:3440-51 (2013)
Mori T†, Yoshizawa K†, Ueno T, Nishiwaki M, Shimizu N, Shibasaki M, Narita M, Suzuki T*. Involvement of dopamine D2 receptor signal transduction in the discriminative stimulus effects of the κ-opioid receptor agonist U-50,488H in rats. Behav Pharmacol 24:275-281 (2013)
Sakai H*, Watanabe Y, Honda M, Tsuiki R, Ueda Y, Nagai Y, Narita M, Misawa M, Chiba Y. Involvement of the Tyr kinase/JNK pathway in carbachol-induced bronchial smooth muscle contraction in the rat. Anesthesiology 118:1076-1085 (2013)
Sakai H*, Hara T, Todoroki K, Igarashi Y, Misawa M, Narita M, Chiba Y. Elevated guanylate cyclase and cyclic-guanosine monophosphate-dependent protein kinase levels in nasal mucosae of antigen-challenged rats. Microvasc Res 90:150-153 (2013)
2012年
Torigoe K, Nakahara K, Rahmadi M, Yoshizawa K, Horiuchi H, Hirayama S, Imai S, Kuzumaki N, Itoh T, Yamashita A, Shakunaga K, Yamasaki M, Nagase H, Matoba M, Suzuki T, Narita M*. Usefulness of olanzapine as an adjunct to opioid treatment and for the treatment of neuropathic pain. Anesthesiology 116:159-169 (2012)
Suzuki M, Narita M, Hasegawa M, Furuta S, Kawamata T, Ashikawa M, Miyano K, Yanagihara K, Chiwaki F, Ochiya T, Suzuki T, Matoba M, Sasaki H, Uezono Y*. Sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied by changes in the expression of substance P and μ-opioid receptors in the spinal cord of mice. Anesthesiology 117:847-856 (2012)
Kuzumaki N, Suzuki A, Narita M, Hosoya T, Nagasawa A, Imai S, Yamamizu K, Morita H, Nagase H, Okada Y, Okano HJ, Yamashita JK, Okano H, Suzuki T, Narita M*. Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells. Br J Cancer 106:1148-1152 (2012)
Kuzumaki N*, Suzuki A, Narita M, Hosoya T, Nagasawa A, Imai S, Yamamizu K, Morita H, Suzuki T, Okada Y, Okano HJ, Yamashita JK, Okano H, Narita M*. Multiple analyses of G-protein coupled receptor (GPCR) expression in the development of gefitinib-resistance in transforming non-small-cell lung cancer. PLoS One 7:e44368 (2012)
Enomoto T, Yamashita A, Torigoe K, Horiuchi H, Hirayama S, Nakahara K, Yanase M, Sakai H, Ikegami D, Nagase H, Suzuki T, Iseki M, Inada E, Narita M*. Effects of mirtazapine on sleep disturbance under neuropathic pain-like state. Synapse 66:483-488 (2012)
Furuta S, Watanabe L, Doi S, Horiuchi H, Matsumoto K, Kuzumaki N, Suzuki T*, Narita M*. Subdiaphragmatic vagotomy increases the sensitivity of lumbar Aδ primary afferent neurons along with voltage-dependent potassium channels in rats. Synapse 66:95-105 (2012)
Furuta S, Matsumoto K, Horie S, Suzuki T*, Narita M*. Subdiaphragmatic vagotomy induces a functional change in visceral Aδ primary afferent fibers in rats. Synapse. 66:369-71 (2012)
Torigoe K, Mori T, Shibasaki M, Yoshizawa K, Narita M, Suzuki T*. Olanzapine suppresses the rewarding and discriminative stimulus effects induced by morphine. Synapse 66:174-179 (2012)
Suzuki M, Narita M, Ashikawa M, Furuta S, Matoba M, Sasaki H, Yanagihara K, Terawaki K, Suzuki T, Uezono Y*. Changes in the melanocortin receptors in the hypothalamus of a rat model of cancer cachexia. Synapse 66:747-751 (2012)
Mori T, Yoshizawa K, Nomura M, Isotani K, Torigoe K, Tsukiyama Y, Narita M*, Suzuki T*. Sigma-1 receptor function is critical for both the discriminative stimulus and aversive effects of the kappa-opioid receptor agonist U-50,488H. Addict Biol 17:717-724 (2012)
Yoshizawa K, Narita M*, Mori T, Miyatake M, Isotani K, Tomiyasu S, Tsukiyama Y, Suzuki T*. Role of dopamine D2 and D3 receptors in mediating the U-50,488H discriminative cue: Comparison with methamphetamine and cocaine. Addict Biol 17:949-955 (2012)
2011年
Narita M*, Niikura K, Nanjo-Niikura K, Narita M, Furuya M, Yamashita A, Saeki M, Matsushima Y, Imai S, Shimizu T, Asato M, Kuzumaki N, Okutsu D, Miyoshi K, Suzuki M, Tsukiyama Y, Konno M, Yomiya K, Matoba M, Suzuki T*. Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex. Pain 152:1358-1372 (2011)
Imai S, Saeki M, Yanase M, Horiuchi H, Abe M, Narita M, Kuzumaki N, Suzuki T*, Narita M*. Change in microRNAs associated with neuronal adaptive responses in the nucleus accumbens under neuropathic pain. J Neurosci 31:15294-15299 (2011)
Yamamizu K, Furuta S, Katayama S, Narita M, Kuzumaki N, Imai S, Nagase H, Suzuki T, Narita M*, Yamashita JK*. The kappa-opioid system regulates endothelial cell differentiation and pathfinding in vascular development. Blood 118:775-785 (2011)
Kuzumaki N, Ikegami D, Tamura R, Hareyama N, Imai S, Narita M, Torigoe K, Niikura K, Takeshima H, Ando T, Igarashi K, Kanno J, Ushijima T, Suzuki T*, Narita M*. Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene is involved in enriched environment-induced neurogenesis. Hippocampus 21:127-132 (2011)
Niikura K, Furuya M, Narita M, Torigoe K, Kobayashi Y, Takemura Y, Yamazaki M, Horiuchi H, Enomoto T, Iseki M, Kinoshita H, Tomiyasu S, Imai S, Kuzumaki N, Suzuki T*, Narita M*. Enhancement of glutamatergic transmission in the cingulate cortex in response to mild noxious stimuli under a neuropathic pain-like state. Synapse 65:424-432 (2011)
Takemura Y, Furuta S, Hirayama S, Miyashita K, Imai S, Narita M, Kuzumaki N, Tsukiyama Y, Yamazaki M*, Suzuki T*, Narita M*. Upregulation of bradykinin receptors is implicated in the pain associated with caerulein-induced acute pancreatitis. Synapse 65:608-616 (2011)
Takemura Y, Yamashita A, Horiuchi H, Furuya M, Yanase M, Niikura K, Imai S, Hatakeyama N, Kinoshita H, Tsukiyama Y, Senba E, Matoba M, Kuzumaki N, Yamazaki M*, Suzuki T*, Narita M*. Effects of gabapentin on brain hyperactivity related to pain and sleep disturbance under a neuropathic pain-like state using fMRI and brain wave analysis. Synapse 65:668-676 (2011)
Imai S, Sudo Y, Nakamura A, Ozeki A, Asato M, Hojo M, Devi LA, Kuzumaki N, Suzuki T, Uezono Y*, Narita M*. Possible involvement of β-endorphin in a loss of the coordinated balance of μ-opioid receptors trafficking processes by fentanyl. Synapse 65:962-966 (2011)
Furuta S, Matsumoto K, Horie S, Suzuki T*, Narita M*. Subdiaphragmatic vagotomy induces sensitization of primary afferent fibers and its beneficial treatment of a 5-HT4 receptor agonist mosapride. Jpn J Pharm Palliat Care Sci 4:93-98 (2011)
Rahmadi M, Narita M*, Yamashita A, Imai S, Kuzumaki N, Suzuki T*. Sleep disturbance associated with an enhanced orexinergic system induced by chronic treatment with paroxetine and milnacipran. Synapse 65:652-657 (2011)
Yoshizawa K, Narita M*, Saeki M, Narita M, Isotani K, Horiuchi H, Imai S, Kuzumaki N, Suzuki T*. Activation of extracellular signal-regulated kinase is critical for the discriminative stimulus effects induced by U-50,488H. Addict Biol, 65:1052-1061 (2011)
Nakamura A, Hasegawa M, Ito H, Minami K, Koike K, Habu-Tomita N, Nanba K, Hamaguchi K, Noshi E, Hashimoto H, Nishino I, Okabayashi Y, Koyabu K, Kihara T, Iwamoto Y, Inoue Y, Narita M, Suzuki T, Kato A*. Distinct relations among plasma concentrations required for different pharmacological effects in oxycodone, morphine, and fentanyl. J Pain Palliat Care Pharmacother 25: 318-334 (2011)
Tsukahara-Ohsumi Y, Tsuji F*, Niwa M, Hata T, Narita M, Suzuki T, Sasano M, Aono H. The kappa opioid receptor agonist SA14867 has antinociceptive and weak sedative effects in models of acute and chronic pain. Eur J Pharmacol 671:53-60 (2011)
