業績に戻る
学術論文その他（東・着任まで）
● 原著論文（英語）
38. Sue M, Higashi N*(corresponding author), Shida H, Kogane Y, Nishimura Y, Adachi H, Kolaczkowska E, Kepka M, Nakajima M, Irimura T.
An iminosugar-based heparanase inhibitor heparastatin (SF4) suppresses infiltration of neutrophils and monocytes into inflamed dorsal air pouches.
Int. Immunopharmacol., 35: 15-21, 2016
37. Tsunekawa N, Higashi N*(corresponding author), Kogane Y, Waki M, Shida H, Nishimura Y, Adachi H, Nakajiima M, Irimura T.
Heparanase augments inflammatory chemokine production from colorectal carcinoma cell lines.
Biochem. Biophys. Res. Commun., 469(4):878-883, 2016
36. Xin X, Akasaka-Manya K, Manya H, Furukawa J, Kuwahara N, Okada K, Tsumoto H, Higashi N, Kato R, Shinohara Y, Irimura T, Endo T.
POMGNT1 Is Glycosylated by Mucin-Type O-Glycans.
Biol. Pharm. Bull., 38(9):1389-1394, 2015
35. Higashi N, Waki M, Sue M, Kogane Y, Shida H, Tsunekawa N, Hasan A, Sato T, Kitahara A, Kasaoka K, Hayakawa Y, Nakajima M, Irimura T.
Heparanase-mediated cleavage of macromolecular heparin accelerates release of granular components of mast cells from extracellular matrices.
Biochem. J., 458(2): 291-299, 2014
34. Kogane Y, Higashi N*(corresponding author), Nishimura Y, Nakajima M, Irimura T.
Heparanase Downmodulation in the Process of Epithelial-to-Mesenchymal Transition of Mouse Mammary Epithelial Cells.
J. Glycomics Lipidomics, 3: 107, 2013.
33. Ueno S, Mojic M, Ohashi Y, Higashi N, Hayakawa Y, Irimura T.
Asialoglycoprotein receptor promotes cancer metastasis by activating the EGFR-ERK pathway.
Cancer Res. 71(20):6419-6427, 2011
32. Kato K, Takeuchi H, Kanoh A, Miyahara N, Nemoto-Sasaki Y, Morimoto-Tomita M, Matsubara A, Ohashi Y, Waki M, Usami K, Mandel U, Clausen H, Higashi N, Irimura T.
Loss of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 and reduced O-glycosylation in colon carcinoma cells selected for hepatic metastasis.
Glycoconj J. 27(2): 267-276, 2010
31. Fang J, Izawa R, Gomez-Santos L, Ueno S, Sawaguchi T, Usami K, Nodera Y, Takeuchi H, Ohashi Y, Higashi N, Irimura T.
Potentiation of proliferation of some but not all human colon carcinoma cell lines by immobilized hepatic asialoglycoprotein receptor 1.
Oncol. Res. 17(10): 437-445, 2009
30. Kumamoto Y, Denda-Nagai K, Aida S, Higashi, N, Irimura T.
MGL2+ dermal dendritic cells are sufficient to initiate contact hypersensitivity in vivo.
PLoS ONE 4(5): e5619, 2009
29. Komatsu N, Waki M, Sue M, Tokuda C, Kasaoka T, Nakajima M, Higashi N, Irimura T.
Heparanase expression in B16 melanoma cells and peripheral blood neutrophils before and after extravasation detected by novel anti-mouse heparanase monoclonal antibodies.
J. Immunol. Methods 331:82-93, 2008
28. Sano Y, Usami K, Izawa R, Denda-Nagai K, Higashi N, Kimura T, Suzuki N, Irimura T.
Properties of blocking and non-blocking monoclonal antibodies specific for human macrophage galactose-type C-type lectin (MGL/ClecSF10A/CD301).
J. Biochem.(Tokyo), 141(1):127-136, 2007
27. Sato K, Higashi N, Kumamoto Y, Irimura T.
Distribution of MGL1 binding sites and MGL1/2-positivee cells in lymph nodes during the sensitization phase of contact hypersensitivity.
Acta Histochem.Cytochem. 38(1):75-80, 2005
26. Sato K, Komatsu N, Higashi N, Imai Y, Irimura T.
Granulation tissue formation by nonspecific inflammatory agent occurs independently of macrophage galactose-type C-type lectin-1.
Clin. Immunol. 115(1):47-50, 2005
25. Sato K, Imai Y, Higashi N, Kumamoto Y, Onami TM, Hedrick SM, Irimura T.
Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a.
Blood 106(1):207-215, 2005
24. Sato K, Imai Y, Higashi N, Kumamoto Y, Mukaida N, Irimura T.
Redistributions ofmmacrophages expressing the macrophage galactose-type C-type lectin (MGL) during antigen-induced chronic granulation tissue formation.
Int Immunol., 17(5):559-568, 2005
23. Sasaki N, Higashi N, Taka T, Nakajima M, Irimura T.
Cell surface localization of heparanase on macrophages regulates degradation of extracellular matrix heparan sulfate.
J Immunol. 172(6):3830-3835, 2004
22. Takada A, Fujioka K, Tsuiji M, Morikawa A, Higashi N, Ebihara H, Kobasa D, Feldmann H, Irimura T, Kawaoka Y.
Human macrophage C-type lectin specific for galactose and N-acetylgalactosamine promotes filovirus entry.
J Virol. 78(6):2943-2947, 2004
21. Kumamoto Y, Higashi N, Denda-Nagai K, Tsuiji M, Sato K, Crocker PR, Irimura T.
Identification of sialoadhesin as a dominant lymph node counter-receptor for mouse macrophage galactose-type C-type lectin 1.
J Biol Chem., 279(47):49274-49280, 2004
20. Ogawa Y, Hahn W, Garnier P, Higashi N, Massotte D, Metz-Boutigue MH, Rousseau B, Kodaka M, Sunamoto J, Ourisson G, Nakatani Y.
Regioselective photolabeling of glycoprotein A in membranes.
Chemistry. 8(8):1843-1849, 2002
19. Tsuiji M, Fujimori M, Ohashi Y, Higashi N, Onami TM, Hedrick SM, Irimura T.
Molecular cloning and characterization of a novel mouse macrophage C-type lectin, mMGL2, which has a distinct carbohydrate specificity from mMGL1.
J. Biol. Chem., 277(32):28892-28901, 2002
18. Higashi N, Ishii H, Fujiwara T, Morimoto-Tomita M, Irimura T. Redistribution of fibroblasts and macrophages as micrometastases develop into established liver metastases.
Clin Exp Metastases, 19(7):631-638, 2002
17. Higashi N, Fujioka K, Denda-Nagai K, Hashimoto S, Nagai S, Sato T, Fujita Y, Morikawa A, Tsuiji M, Miyata-Takeuchi M, Sano Y, Suzuki N, Yamamoto , Matsushima K, Irimura T.
The macrophage C-type lectin specific for galactose/N-acetylgalactosamine is an endocytic receptor expressed on monocyte-derived immature dendritic cells.
J Biol. Chem., 277(23):20686-20693, 2002
16. Higashi N, Morikawa A, Fujioka K, Fujita Y, Sano Y, Miyata-Takeuchi M, Suzuki N, Irimura T.
Human macrophage lectin specific for galactose/N-acetylgalactosamine is a marker for cells at an intermediate stage in their differentiation from monocytes into macrophages.
Int. Immunol., 14(6):545-554, 2002
15. Ogawa Y, Hahn, W, Garnier P, Higashi N, Massotte D, Metz-Boutigue, M-H, Rousseau, B, Sunamoto, J, Ourisson, G, Nakatani Y.
Mid-membrane photolabeling of the transmembrane domain of glycophorin A in phospholipid vesicles.
Angew. Chem. Int. Ed. 40(5):944-946, 2001
14. Chun K-H, Imai Y, Higashi N, Irimura T.
Migration of dermal cells expressing a macrophage C-type lectin during the sensitization phase of delayed-type hypersensitivity.
J Leukocyte Biol, 68(4): 471-478, 2000
13. Chun K-H, Imai Y, Higashi N, Irimura T.
Involvement of cytokines in the skin-to-lymph node trafficking of cells of the monocyte-macrophage lineage expressing a C-type lectin.
Int Immunol, 12(12): 1695-1703, 2000
12. Higashi N, Tsujii K, Sunamoto J
A novel monoclonal antibody that recognizes apical membrane of frog taste cells
Chemical Senses 23 (6): 709-716, 1998
11. Higashi N, Yamauchi M, Okumura Y, Nakanishi M, Sunamoto J
Fusion between Jurkat cell and PEO-lipid modified liposome
Biochim. Biophys. Acta-Biomembranes 1285 (2): 183-191,1996
10. Higashi N, Yoshizuka N, Kobayashi Y
Phenotypic properties and cytokine production of skin-infiltrating cells obtained from guinea pig delayed-type hypersensitivity reaction sites.
Cell. Immunol. 164 (1): 28-35, 1995
9. Higashi N, Yoshizuka N, Ohuchi A, Osawa T, Kobayashi Y
Involvement of inflammatory cytokines in a delayed-type hypersensitivity reaction
Cell. Immunol. 161 (2): 288-294, 1995
8. Higashi N, Sunamoto J
Endocytosis of poly(ethylene oxide)-modified liposome by human lymphoblastoid cells
Biochim. Biophys. Acta-General Subjects 1243 (3): 386-392, 1995
7. Higashi N, Taki H, Nishimura Y, Higuchi M, Osawa T
Chromium and tritiated thymidine releases from target cells are differential events in human monocyte/macrophage-mediated cytotoxicity
Cell. Immunol. 150 (2): 333-342, 1993
6. Higashi N, Higuchi M, Hanada N, Oeda J-I, Kobayashi Y, Osawa T
Identification of human T-cell hybridoma-derived macrophage activating factor as interleukin-2
J. Biochem. 113 (6): 715-720, 1993
5. Nishimura Y, Higashi N, Tsuji T, Higuchi M, Osawa T
Activation of human monocytes by interleukin-2 and various cytokines
J. Immunotherapy 12 (2): 90-97, 1992
4. Higuchi M, Shirotani K, Higashi N, Toyoshima S, Osawa T
Damage to mitochondrial respiration chain is related to phospholipase A2 activation caused by tumor necrosis factor
J. Immunotherapy 12 (1): 41-49, 1992
3. Higuchi M, Higashi N, Nishimura Y, Toyoshima S, Osawa T
TNF-Mediated cytotoxicity – Importance of intracellular cGMP level for determining TNF-sensitivity
Mol. Immunol. 28 (9): 1039-1044, 1991
2. Higashi N, Nishimura Y, Higuchi M, Osawa T
Human monocytes in a long-term culture with interleukin-2 show high tumoricidal activity against various tumor cells.
J. Immunotherapy 10 (4): 247-255, 1991
1. Higuchi M, Higashi N, Taki H, Osawa T
Cytolytic mechanisms of activated macrophages – Tumor necrosis factor and L-arginine-dependent mechanisms act synergistically as the major cytolytic mechanisms of activated macrophages.25-1431, 199.
● 原著論文（和文）
1. 東 伸昭, 辻井 薫, 砂本順三, 味細胞へのアニオン性蛍光色素の選択的導入, 日本味と匂学会誌, 3, 538-541 (1996).
● 総説
9. 東 伸昭．
糖鎖切断酵素ヘパラナーゼは免疫細胞の移動ツールである
アレルギーの臨床 35:1368-1371, 2015
8. 東 伸昭．
硫酸化糖鎖ヘパリンと糖鎖切断酵素ヘパラナーゼはマスト細胞の機能を変える
アレルギーの臨床 35:1169-1173, 2015
7. 東 伸昭．
ヘパラナーゼを介した免疫細胞の機能調節
Pharma Vision News 11:28-31, 2008
（日本薬学会薬学ビジョン部会 部会賞要旨）
6. 東 伸昭、入村 達郎、中島 元夫．
マクロファージの浸潤におけるヘパラナーゼの活性調節機構：接着に伴う酵素の集積は活性を制御するか？
生化学 vol.78 (1):34-38, 2006
5. 東 伸昭、築地 信、入村 達郎．
マクロファージC型レクチンの免疫応答における意義
Molecular Medicine, vol.36 (8):908-913, 1999
4. Okumura Y, Higashi N, Rosilio V, Sunamoto J
Poly(ethylene oxide)-bearing lipids and interaction of functionalized liposomes with intact cells POLY(ETHYLENE GLYCOL) ACS SYMPOSIUM SERIES 680: 82-98, 1997
3. 東 伸昭．
腫瘍壊死因子・リンホトキシン
日本臨床 vol.50 (8 別冊):1939-1944, 1992
2. 東 伸昭、吉塚直伸、小林芳郎．
皮膚とサイトカイン
日本香粧品科学会誌 vol.16 (4):240-246, 1992
1. 東 伸昭、大沢利昭．
腫瘍壊死因子
現代化学 増刊18「サイトカイン」 p.137-153, 1990
● 著書
6. 東 伸昭
免疫応答・炎症を調節するヘパラン硫酸・ヘパリンとヘパラナーゼ
「糖鎖の新機能開発・応用ハンドブック」p.113-116（監修 秋吉一成、エヌティーエス、2015年）
5. 東 伸昭、川島博人
Meeting Report “International Symposium on Glyco-minded Biology of Diseases as a Basis of Pharmaceutical Sciences” Welcome to the Village of Trendy and Thoughtful Sciences!
Trends in Glycoscience and Glycotechnology Vol.25 (142):95-101, 2013
4. 東 伸昭、入村 達郎
ヘパラナーゼ活性の検出
「がん転移研究の実験手法」p.263-267（編 日本がん転移学会、金芳堂、2008年）
3. 東 伸昭
Preface: Special Issue for Glycoimmunology
Trends in Glycoscience and Glycotechnology Vol.14 (79):253-254, 2002
2. 入村 達郎、東 伸昭 細胞表層マーカーとしての糖鎖
「細胞機能と代謝マップII 細胞の動的構造」p.200-205（日本生化学会編、東京化学同人、1998年）
1. 東 伸昭、大沢利昭 ．
マイコプラズマの検出法と除去法
「新生化学実験講座」第12巻 分子免疫学I p.265-270（日本生化学会編、東京化学同人、1989年）
● その他・特許
9. 西村 吉男、東 伸昭、入村 達郎、須江 真由美「抗炎症剤及び薬用組成物」
特許出願２００９−２７３８９９（出願日 :２００９年１２月１日）
特許公開２０１１−１１６６７８（公開日 :２０１１年６月１６日）
8. 入村 達郎、東 伸昭、佐藤 佳代子「肉芽組織形成性疾患の治療のための医薬組成物および方法」
特許出願２００３−３７２７３６（出願日 :２００３年１０月３１日）
特許公開２００５−１３２７９６ （公開日 :２００５年５月２６日）
7. 吉原 徹、梅田 智重、東 伸昭「鼻腔内洗浄具」
特許出願平１０−２４７４３５ （出願日 :１９９８年９月１日）
特許公開２０００−７０３２７ （公開日 :２０００年３月７日）
6. 東 伸昭、吉原 徹、梅田 智重「温熱鼻パック」
特許出願平１０−１６４８８２ （出願日 :１９９８年６月１２日）
特許公開平１１−３４７０５９ （公開日 :１９９９年１２月２１日）
5. 新井 陽一、東 伸昭、金田 高之、小寺 孝範、阪口 美喜夫、江口 泰輝「発熱体」
特許出願平１０−１５２１１４ （出願日 :１９９８年５月１４日）
特許公開平１１−３１８９６６ （公開日 :１９９９年１１月２４日）
4. 東 伸昭、砂本 順三「再構成リポソームと物質導入方法」
特許出願平７−７２１３５ （出願日 :１９９５年３月２９日）
特許公開平７−３１６０４０ （公開日 :１９９５年１２月５日）
3. 東 伸昭、吉塚 直伸、小林 芳郎「モノクローナル抗体」
特許出願平５−２４７７７８ （出願日 :１９９３年１０月４日）
特許公開平７−１０１９９５ （公開日 :１９９５年４月１８日）
2. 西村 慶子、東 伸昭、大沢 利昭「サイトカイン活性化マクロファージ」
特許出願平３−２９６５６７ （出願日 :１９９０年４月１９日）
特許公開平５−１３０８６３ （公開日 :１９９３年５月２８日）
1. 西村 慶子、東 伸昭、大沢 利昭「サイトカイン活性化マクロファージを含有してなる抗腫瘍剤」
特許出願平３−２９６５６８ （出願日 :１９９０年４月１９日）
特許公開平５−１１７１６０ （公開日 :１９９３年５月１４日）