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本研究室での研究につながりのある論文がセミナーで紹介されました。研究や文献紹介の参考にしてください。
３年生は２名で分担して、４年生以上では論文全体を紹介できるように頑張りましょう。
●2025年秋学期
Infiltration and local differentiation of bone marrow-derived integrinβ7-positive mast cell progenitors in atopic dermatitis-like skin. Keith YH, Honda T, Ono S, Lee B, Shibuya R, Hanakawa S, Ishida Y, Nakamizo S, Kabashima K. J Allergy Clin Immunol. 2023 Jan;151(1):159-171.e8. doi: 10.1016/j.jaci.2022.09.011. PMID: 36122789 by SA
The crucial role of intercellular calcium wave propagation triggered by influenza A virus in promoting infection. Kozawa F, Tamura T, Takahashi N, Kakizuka T, Ichimura T, Shimada R, Hashimoto Y, Onizuska H, Kashiwagi S, Kamasaki T, Amano M, Nagai T, Fukuhara T, Fujioka Y, Ohba Y. Cell Commun Signal. 2025 Aug 2;23(1):361. doi: 10.1186/s12964-025-02357-y. PMID: 40753252 by YK
Heparanase inhibitor OGT 2115 induces prostate cancer cell apoptosis via the downregulation of MCL‑1. Li X, Xu SJ, Jin B, Lu HS, Zhao SK, Ding XF, Xu LL, Li HJ, Liu SC, Chen J, Chen G. Oncol Lett. 2024 Jan 5;27(2):83. doi: 10.3892/ol.2024.14217. PMID: 38249815 by KS
Fc-optimized CD276 antibody enhances NK cell activation against non-small cell lung cancer. Stefańczyk SA, Kaiser X, Hagelstein I, Holzmayer S, Zekri L, Jung S, Märklin M. Front Immunol. 2025 Jul 31;16:1624751. doi: 10.3389/fimmu.2025.1624751. PMID: 40821788 by RS
ApoE3 R136S binds to Tau and blocks its propagation, suppressing neurodegeneration in mice with Alzheimer's disease. Chen G, Wang M, Zhang Z, Hong DK, Ahn EH, Liu X, Kang SS, Ye K. Neuron. 2025 Mar 5;113(5):719-736.e5. doi: 10.1016/j.neuron.2024.12.015. PMID: 39814008 by MH
Retinoid X receptor γ interacts with peroxisome proliferator-activated receptor-γ to promote browning during adipose tissue differentiation. Chen D, Woraikat S, Guo X, Yang F, Tang C, He F, Qian K. Adipocyte. 2025 Dec;14(1):2548780. doi: 10.1080/21623945.2025.2548780. PMID: 40855678 by NH
Stanniocalcin 1 and 1,25-dihydroxyvitamin D3 cooperatively regulate bone mineralization by osteoblasts. Kim JH, Kim K, Kim I, Seong S, Koh JT, Kim N. Exp Mol Med. 2024 Sep;56(9):1991-2001. doi: 10.1038/s12276-024-01302-2. Epub 2024 Sep 2. PMID: 39218976 by KH
SDC4 identified as an oncogenic target gene of NF-kappaB in TNFalpha-Induced tumor cells. Zhou F, Li Y, Tang Z, Chen C, Xie X, Li Y, Chen Z, Zou X, Zhu H. Sci Rep. 2025 May 8;15(1):16103. doi: 10.1038/s41598-025-00793-x. PMID: 40341546 by MM
STK40 inhibits trophoblast fusion by mediating COP1 ubiquitination to degrade P57Kip2. Li X, Shao LZ, Li ZH, Wang YH, Cai QY, Wang S, Chen H, Sheng J, Luo X, Chen XM, Wang YX, Ding YB, Liu TH. J Transl Med. 2024 Sep 20;22(1):852. doi: 10.1186/s12967-024-05360-y. PMID: 39304928 by MF
Sodium-Glucose Cotransporter-2 Inhibitor Enhances Hepatic Gluconeogenesis and Reduces Lipid Accumulation via AMPK-SIRT1 Activation and Autophagy Induction. Lee SW, Park H, Lee M, Lee H, Kang ES. Endocrinol Metab (Seoul). 2025 Aug;40(4):583-597. doi: 10.3803/EnM.2024.2223. Epub 2025 May 12. PMID: 40350800 by KM
CD44 Expression Intensity Marks Colorectal Cancer Cell Subpopulations with Different Extracellular Vesicle Release Capacity. Kelemen A, Carmi I, Seress I, Lőrincz P, Tölgyes T, Dede K, Bursics A, Buzás EI, Wiener Z. Int J Mol Sci. 2022 Feb 16;23(4):2180. doi: 10.3390/ijms23042180. PMID: 35216292 by MW
●2025年春学期
Fbxo22 promotes cervical cancer progression via targeting p57Kip2 for ubiquitination and degradation. Lin M, Zhang J, Bouamar H, Wang Z, Sun LZ, Zhu X. Cell Death Dis. 2022 Sep 20;13(9):805. doi: 10.1038/s41419-022-05248-z. PMID: 36127346 By MF, KH
Vaccination with recombinant Lactococcus lactis expressing HA1-IgY Fc fusion protein provides protective mucosal immunity against H9N2 avian influenza virus in chickens. Zhang R, Xu T, Li Z, Li L, Li C, Li X, Wang Z, Wang S, Wang X, Zhang H. Virol J. 2023 Apr 21;20(1):76. doi: 10.1186/s12985-023-02044-9. PMID: 37085816 By YK, RS
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioma cell invasion through induction of NF-kappaB-inducing kinase (NIK) and noncanonical NF-kappaB signaling. Cherry EM, Lee DW, Jung JU, Sitcheran R. Mol Cancer. 2015 Jan 27;14(1):9. doi: 10.1186/s12943-014-0273-1. PMID: 25622756 By SA, KS
The Different Mechanisms of Lipid Accumulation in Hepatocytes Induced by Oleic Acid/Palmitic Acid and High-Fat Diet. Zhang M, Bai X, Du Q, Xu J, Wang D, Chen L, Dong K, Chen Z, Yang J. Molecules. 2023 Sep 20;28(18):6714. doi: 10.3390/molecules28186714. PMID: 37764494 By NH, KM
RUNX2 prompts triple negative breast cancer drug resistance through TGF-β pathway regulating breast cancer stem cells. Lv F, Si W, Xu X, He X, Wang Y, Li Y, Li F. Neoplasia. 2024 Feb;48:100967. doi: 10.1016/j.neo.2024.100967. Epub 2024 Jan 13. PMID: 38219710 By MH, MM, MW
●2024年秋学期Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit. Ashley B, Simner C, Manousopoulou A, Jenkinson C, Hey F, Frost JM, Rezwan FI, White CH, Lofthouse EM, Hyde E, Cooke LDF, Barton S, Mahon P, Curtis EM, Moon RJ, Crozier SR, Inskip HM, Godfrey KM, Holloway JW, Cooper C, Jones KS, Lewis RM, Hewison M, Garbis SDD, Branco MR, Harvey NC, Cleal JK. Elife. 2022 Mar 8;11:e71094. doi: 10.7554/eLife.71094. PMID: 35256050 By HO
β1-Integrin-Mediated Uptake of Chondrocyte Extracellular Vesicles Regulates Chondrocyte Homeostasis. Hussain MT, Austin-Williams S, Wright TD, Dhawan UK, Pinto AL, Cooper D, Norling LV. Int J Mol Sci. 2024 Apr 26;25(9):4756. doi: 10.3390/ijms25094756. PMID: 38731975 By RN
Heparanase is a regulator of natural killer cell activation and cytotoxicity. Mayfosh AJ, Goodall KJ, Nguyen T, Baschuk N, Hulett MD. J Leukoc Biol. 2022 Jun;111(6):1211-1224. doi: 10.1002/JLB.3A0420-259RR. Epub 2021 Oct 24. PMID: 34693552 By TH
Glycosaminoglycan modifications of betaglycan regulate ectodomain shedding to fine-tune TGF-β signaling responses in ovarian cancer. Choi AS, Jenkins-Lane LM, Barton W, Kumari A, Lancaster C, Raulerson C, Ji H, Altomare D, Starr MD, Whitaker R, Phaeton R, Arend R, Shtutman M, Nixon AB, Hempel N, Lee NY, Mythreye K. Cell Commun Signal. 2024 Feb 15;22(1):128. doi: 10.1186/s12964-024-01496-y. PMID: 38360757 By HT
Antimigratory effects of a new NF-κB inhibitor, (S)-b-salicyloylamino-a-exo-methylene-ƴ-butyrolactone, in 2D and 3D breast cancer models. Poma P, Rigogliuso S, Labbozzetta M, Carfì Pavia F, Carbone C, Ma J, Cusimano A, Notarbartolo M. Biomed Pharmacother. 2024 Nov;180:117552. doi: 10.1016/j.biopha.2024.117552. Epub 2024 Oct 18. PMID: 39426283 By SS
A High-Fat Diet Attenuates AMPK alpha1 in Adipocytes to Induce Exosome Shedding and Nonalcoholic Fatty Liver Development In Vivo. Yan C, Tian X, Li J, Liu D, Ye D, Xie Z, Han Y, Zou MH. Diabetes. 2021 Feb;70(2):577-588. doi: 10.2337/db20-0146. Epub 2020 Dec 1. PMID: 33262120 by NT
Matrix metalloproteinases mediate influenza A-associated shedding of the alveolar epithelial glycocalyx. Schaaf KR, Landstreet SR, Putz ND, Gonski SK, Lin J, Buggs CJ, Gibson D, Langouët-Astrié CJ, Jetter CS, Negretti NM, Sucre JMS, Schmidt EP, Ware LB, Bastarache JA, Shaver CM. PLoS One. 2024 Sep 23;19(9):e0308648. doi: 10.1371/journal.pone.0308648. eCollection 2024. PMID: 39312544 By YA
The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates. Ferreira A, Royaux I, Liu J, Wang Z, Su G, Moechars D, Callewaert N, De Muynck L. BMC Mol Cell Biol. 2022 Dec 24;23(1):61. doi: 10.1186/s12860-022-00462-1. PMID: 36564747 By SM
Syndecan-1 Facilitates the Human Mesenchymal Stem Cell Osteo-Adipogenic Balance. Yu C, Peall IW, Pham SH, Okolicsanyi RK, Griffiths LR, Haupt LM. Int J Mol Sci. 2020 May 29;21(11):3884. doi: 10.3390/ijms21113884. PMID: 32485953 by KS
Abnormal basement membrane results in increased keratinocyte-derived periostin expression in psoriasis similar to wound healing. Flink LB, Ghaffarinia A, Papp BT, Varga Á, Vigh AI, Vidács DL, Kui R, Kemény L, Bata-Csörgő Z, Bozó R. Sci Rep. 2023 Sep 29;13(1):16386. doi: 10.1038/s41598-023-43396-0. PMID: 37773198 by DT
Syndecan-1-Dependent Regulation of Heparanase Affects Invasiveness, Stem Cell Properties, and Therapeutic Resistance of Caco2 Colon Cancer Cells. Katakam SK, Pelucchi P, Cocola C, Reinbold R, Vlodavsky I, Greve B, Götte M. Front Oncol. 2020 May 14;10:774. doi: 10.3389/fonc.2020.00774. eCollection 2020. PMID: 32477959 by NY
Therapeutic antibody engineering for efficient targeted degradation of membrane proteins in lysosomes. Gauthier C, Daurat M, Ali LMA, El Cheikh K, El Bahlagui I, Taliercio C, Morère E, Gary-Bobo M, Morère A, Garcia M, Maynadier M, Basile I. Biomed Pharmacother. 2024 Jun;175:116707. doi: 10.1016/j.biopha.2024.116707. Epub 2024 May 12. PMID: 38739989 by RH
SOD3 Suppresses the Expression of MMP-1 and Increases the Integrity of Extracellular Matrix in Fibroblasts. Kim JH, Jeong HD, Song MJ, Lee DH, Chung JH, Lee ST. Antioxidants (Basel). 2022 May 9;11(5):928. doi: 10.3390/antiox11050928. PMID: 35624792 by AO
PFKFB3-dependent glucose metabolism regulates 3T3-L1 adipocyte development. Griesel BA, Matsuzaki S, Batushansky A, Griffin TM, Humphries KM, Olson AL. FASEB J. 2021 Jul;35(7):e21728. doi: 10.1096/fj.202100381RR. PMID: 34110658 by KT
●2024年春学期
SDC2 Stabilization by USP14 Promotes Gastric Cancer Progression through Co-option of PDK1. Li You , Yi Dou , Yu Zhang, Hongwei Xiao, Hong Lv, Gong-Hong Wei, Dazhi Xu Int J Biol Sci. 2023 Jul 9;19(11):3483-3498.doi: 10.7150/ijbs.84331. PMID: 37496999 by HO, KS
The effect of quercetin on adipogenesis, lipolysis, and apoptosis in 3T3-L1 adipocytes: The role of SIRT1 pathways. Mohammad Hasan Maleki, Sara Abdizadeh Javazm, Sanaz Dastghaib, Anahita Panji, Mohammad Hojjati Far, Hajar Mahmoodi, Morvarid Siri, Sayed Mohammad Shafiee Obes Sci Pract. 2024 Apr 13;10(2):e752. doi: 10.1002/osp4.752. PMID: 38618521 by NT,KT
Hypoxia-Derived Exosomes Promote Lung Adenocarcinoma by Regulating HS3ST1-GPC4-Mediated Glycolysis. Xianxiu Ji, Ren Zhu, Caixia Gao, Huikang Xie, Xiaomei Gong, Jie Luo. Cancers (Basel). 2024 Feb 6;16(4):695.doi: 10.3390/cancers16040695. PMID: 38398086 by AO,RN
Cell volume expansion and local contractility drive collective invasion of the basement membrane in breast cancer. Julie Chang , Aashrith Saraswathibhatla , Zhaoqiang Song, Sushama Varma, Colline Sanchez, Naomi Hassan Kahtan Alyafei, Dhiraj Indana, Raleigh Slyman, Sucheta Srivastava, Katherine Liu, Michael C Bassik, M Peter Marinkovich, Louis Hodgson, Vivek Shenoy, Robert B West, Ovijit Chaudhuri Nat Mater. 2024 May;23(5):711-722. doi: 10.1038/s41563-023-01716-9. PMID: 37957268 by SS, HT, RH
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue. Hunter A Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K Reid, Nadine Nagy, Graham Barlow, Ben A Falk, Carlos O Medina, Aviv Hargil, Svenja Zihsler, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H Meyer, Lucile E Wrenshall, James D Lord, K Christopher Garcia, Theo D Palmer, Lawrence Steinman, Gerald T Nepom, Thomas N Wight, Paul L Bollyky, Hedwich F Kuipers. Nat Commun. 2024 Feb 20;15(1):1564. doi: 10.1038/s41467-024-45012-9. PMID: 38378682 by DT,TH,YA
Heparan sulfate promotes TRAIL-induced tumor cell apoptosis. Yin Luo, Huanmeng Hao, Zhangjie Wang, Chih Yean Ong, Robert Dutcher, Yongmei Xu, Jian Liu, Lars C Pedersen, Ding Xu. Elife. 2024 Jan 24:12:RP90192.doi: 10.7554/eLife.90192. PMID: 38265424 by SM,NY
●2023年秋学期
Spatial collagen stiffening promotes collective breast cancer cell invasion by reinforcing extracellular matrix alignment. Koorman T, Jansen KA, Khalil A, Haughton PD, Visser D, Rätze MAK, Haakma WE, Sakalauskaitè G, van Diest PJ, de Rooij J, Derksen PWB. Oncogene. 2022 Apr;41(17):2458-2469. doi: 10.1038/s41388-022-02258-1. Epub 2022 Mar 15. PMID: 35292774 by MA
Syndecan-4 proteoliposomes enhance revascularization in a rabbit hind limb ischemia model of peripheral ischemia. Sligar AD, Howe G, Goldman J, Felli P, Gómez-Hernández A, Takematsu E, Veith A, Desai S, Riley WJ, Singeetham R, Mei L, Callahan G, Ashirov D, Smalling R, Baker AB. Acta Biomater. 2023 Sep 1;167:425-435. doi: 10.1016/j.actbio.2023.06.006. Epub 2023 Jun 13. PMID: 37321528 by KA
Inhibitory Effect of Styrylpyrone Extract of Phellinus linteus on Hepatic Steatosis in HepG2 Cells. Chiu CH, Chen MY, Lieu JJ, Chen CC, Chang CC, Chyau CC, Peng RY. Int J Mol Sci. 2023 Feb 12;24(4):3672. doi: 10.3390/ijms24043672. PMID: 36835095 by MI
APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation. Marino C, Perez-Corredor P, O'Hare M, Heuer A, Chmielewska N, Gordon H, Chandrahas AS, Gonzalez-Buendia L, Delgado-Tirado S, Doan TH, Vanderleest TE, Arevalo-Alquichire S, Obar RA, Ortiz-Cordero C, Villegas A, Sepulveda-Falla D, Kim LA, Lopera F, Mahley R, Huang Y, Quiroz YT, Arboleda-Velasquez JF. Alzheimers Dement. 2023 Oct 4. doi: 10.1002/alz.13436. Online ahead of print. PMID: 37791598 by NS
Extracellular vesicles released by glioma cells are decorated by Annexin A2allowing for cellular uptake via heparan sulfate. Song YX, Li X, Nie SD, Hu ZX, Zhou D, Sun DY, Zhou GY, Wang Y, Liu JJ, Song T, Wang S. Cancer Gene Ther. 2023 Aug;30(8):1156-1166. doi: 10.1038/s41417-023-00627-w. Epub 2023 May 25. PMID: 37231059 by YS
1-Iodohexadecane Alleviates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice: Possible Involvements of the Skin Barrier and Mast Cell SNARE Proteins. Kim DY, Won KJ, Hwang DI, Kim NY, Kim B, Lee HM. Molecules. 2022 Feb 25;27(5):1560. doi: 10.3390/molecules27051560. PMID: 35268661 by RT
Mitochondrial citrate metabolism and efflux regulate BeWo differentiation. Mahr RM, Jena S, Nashif SK, Nelson AB, Rauckhorst AJ, Rome FI, Sheldon RD, Hughey CC, Puchalska P, Gearhart MD, Taylor EB, Crawford PA, Wernimont SA. Sci Rep. 2023 May 6;13(1):7387. doi: 10.1038/s41598-023-34435-x. PMID: 37149697 by YT
1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage. Xie H, Bastepe I, Zhou W, Ay B, Ceraj Z, Portales-Castillo IA, Liu ES, Burnett-Bowie SM, Jüppner H, Rhee EP, Bastepe M, Simic P. JCI Insight. 2023 Sep 8;8(17):e168957. doi: 10.1172/jci.insight.168957. PMID: 37681408 by MN
Plasma membrane proteoglycans syndecan-2 and syndecan-4 engage with EGFR and RON kinase to sustain carcinoma cell cycle progression. Beauvais DM, Nelson SE, Adams KM, Stueven NA, Jung O, Rapraeger AC. J Biol Chem. 2022 Jun;298(6):102029. doi: 10.1016/j.jbc.2022.102029. Epub 2022 May 13. PMID: 35569509 by YF
The transcription factor Foxp1 regulates aerobic glycolysis in adipocytes and myocytes. Ma H, Sukonina V, Zhang W, Meng F, Subhash S, Palmgren H, Alexandersson I, Han H, Zhou S, Bartesaghi S, Kanduri C, Enerbäck S. J Biol Chem. 2023 Jun;299(6):104795. doi: 10.1016/j.jbc.2023.104795. Epub 2023 May 5. PMID: 37150320 by KF
Delivery of a novel membrane-anchored Fc chimera enhances NK cell-mediated killing of tumor cells and persistently virus-infected cells. Varudkar N, Shiffer EM, Oyer JL, Copik A, Parks GD. PLoS One. 2023 May 5;18(5):e0285532. PMID: 37146009 by AY
●2023年春学期
Pathophysiology of reinfection by exogenous HSV-1 is driven by heparanase dysfunction. Suryawanshi RK, Patil CD, Agelidis A, Koganti R, Yadavalli T, Ames JM, Borase H, Shukla D. Sci Adv. 2023 Apr 28;9(17):eadf3977. doi: 10.1126/sciadv.adf3977. Epub 2023 Apr 28. PMID: 37115924 by MA, YS
Effects of chondroitin sulfate oligosaccharides on osteoclast differentiation of RAW264 cells, and myotube differentiation of C2C12 cells. Uchiyama H, Muramatsu D, Higashi H, Kida H, Iwai A. PLoS One. 2023 Apr 13;18(4):e0284343. doi: 10.1371/journal.pone.0284343. eCollection 2023. PMID: 37053208 by NS, MN, KH
Heparin is required for the formation of granules in connective tissue mast cells. Herrera-Heredia SA, Hsu HP, Kao CY, Tsai YH, Yamaguchi Y, Roers A, Hsu CL, Dzhagalov IL. Front Immunol. 2022 Nov 9;13:1000405. doi: 10.3389/fimmu.2022.1000405. eCollection 2022. PMID: 36439118 by KA, RT
Heparanase 2 (Hpa2) attenuates the growth of human sarcoma. Knani I, Yanku Y, Gross-Cohen M, Ilan N, Vlodavsky I. Matrix Biol. 2022 Nov;113:22-38. doi: 10.1016/j.matbio.2022.09.003. Epub 2022 Sep 17. PMID: 36122821 by YF, AY
CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway. Deleye Y, Cotte AK, Hannou SA, Hennuyer N, Bernard L, Derudas B, Caron S, Legry V, Vallez E, Dorchies E, Martin N, Lancel S, Annicotte JS, Bantubungi K, Pourtier A, Raverdy V, Pattou F, Lefebvre P, Abbadie C, Staels B, Haas JT, Paumelle R. J Biol Chem. 2020 Dec 11;295(50):17310-17322. doi: 10.1074/jbc.RA120.012543. Epub 2020 Oct 9. PMID: 33037071
●2022年秋学期
Mice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation. Poon IK, Goodall KJ, Phipps S, Chow JD, Pagler EB, Andrews DM, Conlan CL, Ryan GF, White JA, Wong MK, Horan C, Matthaei KI, Smyth MJ, Hulett MD. Eur J Immunol. 2014 Apr;44(4):1016-30. doi: 10.1002/eji.201343645. Epub 2014 Feb 14. PMID: 24532362 by YI
Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and regulates the HA metabolism, proliferation and differentiation of fibroblasts. Schmaus A, Rothley M, Schreiber C, Möller S, Roßwag S, Franz S, Garvalov BK, Thiele W, Spataro S, Herskind C, Prunotto M, Anderegg U, Schnabelrauch M, Sleeman J. Matrix Biol. 2022 May;109:173-191. doi: 10.1016/j.matbio.2022.04.001. Epub 2022 Apr 8. PMID: 35405271 by IO
L226Q Mutation on Influenza H7N9 Virus Hemagglutinin Increases Receptor-Binding Avidity and Leads to Biased Antigenicity Evaluation. Wang Y, Lv Y, Niu X, Dong J, Feng P, Li Q, Xu W, Li J, Li C, Li J, Luo J, Li Z, Liu Y, Tan YJ, Pan W, Chen L. J Virol. 2020 Sep 29;94(20):e00667-20. doi: 10.1128/JVI.00667-20. Print 2020 Sep 29. PMID: 32796071 by NK
Knockout of syntaxin-4 in 3T3-L1 adipocytes reveals new insight into GLUT4 trafficking and adiponectin secretion. Black HL, Livingstone R, Mastick CC, Al Tobi M, Taylor H, Geiser A, Stirrat L, Kioumourtzoglou D, Petrie JR, Boyle JG, Bryant NJ, Gould GW. J Cell Sci. 2022 Dec 1;135(1):jcs258375. doi: 10.1242/jcs.258375. Epub 2022 Jan 10. PMID: 34859814 by AK
Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model. Guzman S, Dragan M, Kwon H, de Oliveira V, Rao S, Bhatt V, Kalemba KM, Shah A, Rustgi VK, Wang H, Bech PR, Abbara A, Izzi-Engbeaya C, Manousou P, Guo JY, Guo GL, Radovick S, Dhillo WS, Wondisford FE, Babwah AV, Bhattacharya M. J Clin Invest. 2022 May 16;132(10):e145889. doi: 10.1172/JCI145889. PMID: 35349482 by KK
Hepatocyte-Specific Deletion of HIF2α Prevents NASH-Related Liver Carcinogenesis by Decreasing Cancer Cell Proliferation. Foglia B, Sutti S, Cannito S, Rosso C, Maggiora M, Autelli R, Novo E, Bocca C, Villano G, Ramavath NN, Younes R, Tusa I, Rovida E, Pontisso P, Bugianesi E, Albano E, Parola M. Cell Mol Gastroenterol Hepatol. 2022;13(2):459-482. doi: 10.1016/j.jcmgh.2021.10.002. Epub 2021 Oct 14. PMID: 34655812 by KS
Tetraspanin-6 negatively regulates exosome production. Ghossoub R, Chéry M, Audebert S, Leblanc R, Egea-Jimenez AL, Lembo F, Mammar S, Le Dez F, Camoin L, Borg JP, Rubinstein E, David G, Zimmermann P. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5913-5922. doi: 10.1073/pnas.1922447117. Epub 2020 Feb 27. PMID: 32108028 by KN
Targeting all transforming growth factor-β isoforms with an Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer. Takahashi K, Akatsu Y, Podyma-Inoue KA, Matsumoto T, Takahashi H, Yoshimatsu Y, Koinuma D, Shirouzu M, Miyazono K, Watabe T. J Biol Chem. 2020 Sep 4;295(36):12559-12572. doi: 10.1074/jbc.RA120.012492. Epub 2020 Jul 6. PMID: 32631954 by MN
Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis. Purushothaman A, Uyama T, Kobayashi F, Yamada S, Sugahara K, Rapraeger AC, Sanderson RD. Blood. 2010 Mar 25;115(12):2449-57. doi: 10.1182/blood-2009-07-234757. Epub 2010 Jan 22. PMID: 20097882 by EN
A murine model of atopic dermatitis can be generated by painting the dorsal skin with hapten twice 14 days apart. Kitamura A, Takata R, Aizawa S, Watanabe H, Wada T. Sci Rep. 2018 Apr 16;8(1):5988. doi: 10.1038/s41598-018-24363-6. PMID: 29662233 by YH
Heparanase modulates the prognosis and development of BRAF V600E-mutant colorectal cancer by regulating AKT/p27Kip1/Cyclin E2 pathway. Liu M, Xu X, Peng K, Hou P, Yuan Y, Li S, Sun X, Shi Z, Zhang J, Dong Y, Liu Q, Ai L, Liang L, Gan L, Huang Q, Yu Y, Liu T. Oncogenesis. 2022 Sep 21;11(1):58. doi: 10.1038/s41389-022-00428-0. PMID: 36130926 by MY
●2022年春学期
Lipopolysaccharide suppresses IgE-mast cell-mediated reactions. Wang N, McKell M, Dang A, Yamani A, Waggoner L, Vanoni S, Noah T, Wu D, Kordowski A, Köhl J, Hoebe K, Divanovic S, Hogan SP. Clin Exp Allergy. 2017 Dec;47(12):1574-1585. doi: 10.1111/cea.13013. Epub 2017 Oct 10. PMID: 28833704 by YI, YH
Heparan sulfate is a clearance receptor for aberrant extracellular proteins. Itakura E, Chiba M, Murata T, Matsuura A. J Cell Biol. 2020 Mar 2;219(3):e201911126. doi: 10.1083/jcb.201911126. PMID: 32211892 by IO, YK
Disordered metabolism in mice lacking irisin. Luo Y, Qiao X, Ma Y, Deng H, Xu CC, Xu L. Sci Rep. 2020 Oct 15;10(1):17368. doi: 10.1038/s41598-020-74588-7. PMID: 33060792 by RK, AK
DHA Protects Against Hepatic Steatosis by Activating Sirt1 in a High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mouse Model. Luo X, He Z, Sun X, Gu X, Zhang W, Gao J, Li X, Jia R, Wei J, Yu Y, Luo X. Diabetes Metab Syndr Obes. 2020 Jan 22;13:185-196. doi: 10.2147/DMSO.S232279. eCollection 2020. PMID: 32158242 by KK, KS
The tumor suppressor p53 can promote collective cellular migration. He S, Carman CV, Lee JH, Lan B, Koehler S, Atia L, Park CY, Kim JH, Mitchel JA, Park JA, Butler JP, Lu Q, Fredberg JJ. PLoS One. 2019 Feb 1;14(2):e0202065. doi: 10.1371/journal.pone.0202065. eCollection 2019. PMID: 30707705 by MN, EN
The Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 Promotes Ovarian Cancer Pathogenesis. Hillemeyer L, Espinoza-Sanchez NA, Greve B, Hassan N, Chelariu-Raicu A, Kiesel L, Götte M. Int J Mol Sci. 2022 May 21;23(10):5793. doi: 10.3390/ijms23105793. PMID: 35628603 by KN, MY
●2021年秋学期
Heparin-binding motif mutations of human diamine oxidase allow the development of a first-in-class histamine-degrading biopharmaceutical. Gludovacz E, Schuetzenberger K, Resch M, Tillmann K, Petroczi K, Schosserer M, Vondra S, Vakal S, Klanert G, Pollheimer J, Salminen TA, Jilma B, Borth N, Boehm T. Elife. 2021 Sep 3;10:e68542. doi: 10.7554/eLife.68542. PMID: 34477104 by SA
Chemotherapy induces expression and release of heparanase leading to changes associated with an aggressive tumor phenotype. Ramani VC, Vlodavsky I, Ng M, Zhang Y, Barbieri P, Noseda A, Sanderson RD. Matrix Biol. 2016 Sep;55:22-34. doi: 10.1016/j.matbio.2016.03.006. Epub 2016 Mar 22. PMID: 27016342 by RE
Dexamethasone induces osteoblast apoptosis through ROS-PI3K/AKT/GSK3β signaling pathway. Deng S, Dai G, Chen S, Nie Z, Zhou J, Fang H, Peng H. Biomed Pharmacother. 2019 Feb;110:602-608. doi: 10.1016/j.biopha.2018.11.103. Epub 2018 Dec 8. PMID: 30537677 by RW
Antitumor activity of sulfated hyaluronic acid fragments in pre-clinical models of bladder cancer. Jordan AR, Lokeshwar SD, Lopez LE, Hennig M, Chipollini J, Yates T, Hupe MC, Merseburger AS, Shiedlin A, Cerwinka WH, Liu K, Lokeshwar VB. Oncotarget. 2017 Apr 11;8(15):24262-24274. doi: 10.18632/oncotarget.10529. PMID: 27419371 by YO
A Unique Nonsaccharide Mimetic of Heparin Hexasaccharide Inhibits Colon Cancer Stem Cells via p38 MAP Kinase Activation. Boothello RS, Patel NJ, Sharon C, Abdelfadiel EI, Morla S, Brophy DF, Lippman HR, Desai UR, Patel BB. Mol Cancer Ther. 2019 Jan;18(1):51-61. doi: 10.1158/1535-7163.MCT-18-0104. Epub 2018 Oct 18. PMID: 30337351 by YO
The PPAR α/γ Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease. Kumar DP, Caffrey R, Marioneaux J, Santhekadur PK, Bhat M, Alonso C, Koduru SV, Philip B, Jain MR, Giri SR, Bedossa P, Sanyal AJ. Sci Rep. 2020 Jun 9;10(1):9330. doi: 10.1038/s41598-020-66458-z. PMID: 32518275 by MK
Elucidating the Consequences of Heparan Sulfate Binding by Heparanase 2. Gross-Cohen M, Feld S, Arvatz G, Ilan N, Vlodavsky I. Front Oncol. 2021 Jan 29;10:627463. doi: 10.3389/fonc.2020.627463. eCollection 2020. PMID: 33585253 by KK
Microenvironmental pH and Exosome Levels Interplay in Human Cancer Cell Lines of Different Histotypes. Logozzi M, Mizzoni D, Angelini DF, Di Raimo R, Falchi M, Battistini L, Fais S. Cancers (Basel). 2018 Oct 5;10(10):370. doi: 10.3390/cancers10100370. PMID: 30301144 by NS
Heparanase Promotes Tumor Growth and Liver Metastasis of Colorectal Cancer Cells by Activating the p38/MMP1 Axis. Liu X, Zhou ZH, Li W, Zhang SK, Li J, Zhou MJ, Song JW. Front Oncol. 2019 Apr 2;9:216. doi: 10.3389/fonc.2019.00216. eCollection 2019. PMID: 31001480 by KS
Peptides with the multibasic cleavage site of the hemagglutinin from highly pathogenic influenza viruses act as cell-penetrating via binding to heparansulfate and neuropilins. Yamamoto Y, Tamiya S, Shibuya M, Nakase I, Yoshioka Y. Biochem Biophys Res Commun. 2019 May 7;512(3):453-459. doi: 10.1016/j.bbrc.2019.03.068. Epub 2019 Mar 21. PMID: 30904159 by HS
Alpha or beta human chorionic gonadotropin knockdown decrease BeWo cell fusion by down-regulating PKA and CREB activation. Malhotra SS, Suman P, Gupta SK. Sci Rep. 2015 Jun 8;5:11210. doi: 10.1038/srep11210. PMID: 26053549 by AN
Thymic stromal lymphopoietin-induced interleukin-17A is involved in the development of IgE-mediated atopic dermatitis-like skin lesions in mice. Mizutani N, Sae-Wong C, Kangsanant S, Nabe T, Yoshino S. Immunology. 2015 Dec;146(4):568-81. doi: 10.1111/imm.12528. Epub 2015 Sep 24. PMID: 26310839 by MH
Screening of the HBx transactivation domain interacting proteins and the function of interactor Pin1 in HBV replication. Zhou Q, Yan L, Xu B, Wang X, Sun X, Han N, Tang H, Huang F. Sci Rep. 2021 Jul 8;11(1):14176. doi: 10.1038/s41598-021-93584-z. PMID: 34238995 by YF
Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response. O'Callaghan P, Li JP, Lannfelt L, Lindahl U, Zhang X. J Biol Chem. 2015 Jun 12;290(24):14904-14. doi: 10.1074/jbc.M114.634337. Epub 2015 Apr 13. PMID: 25869127 by NF
MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines. Vultur A, Villanueva J, Krepler C, Rajan G, Chen Q, Xiao M, Li L, Gimotty PA, Wilson M, Hayden J, Keeney F, Nathanson KL, Herlyn M. Oncogene. 2014 Apr 3;33(14):1850-61. doi: 10.1038/onc.2013.131. Epub 2013 Apr 29. PMID: 23624919 by HM
●2021年春学期（オンライン）
SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2. Clausen TM, Sandoval DR, Spliid CB, Pihl J, Perrett HR, Painter CD, Narayanan A, Majowicz SA, Kwong EM, McVicar RN, Thacker BE, Glass CA, Yang Z, Torres JL, Golden GJ, Bartels PL, Porell RN, Garretson AF, Laubach L, Feldman J, Yin X, Pu Y, Hauser BM, Caradonna TM, Kellman BP, Martino C, Gordts PLSM, Chanda SK, Schmidt AG, Godula K, Leibel SL, Jose J, Corbett KD, Ward AB, Carlin AF, Esko JD. Cell. 2020 Nov 12;183(4):1043-1057.e15. doi: 10.1016/j.cell.2020.09.033. Epub 2020 Sep 14. PMID: 32970989 by YI
Hypoxia-induced mitochondrial abnormalities in cells of the placenta. Vangrieken P, Al-Nasiry S, Bast A, Leermakers PA, Tulen CBM, Janssen GMJ, Kaminski I, Geomini I, Lemmens T, Schiffers PMH, van Schooten FJ, Remels AHV. PLoS One. 2021 Jan 12;16(1):e0245155. doi: 10.1371/journal.pone.0245155. eCollection 2021. PMID: 33434211 by RK
Interleukin-17 promotes prostate cancer via MMP7-induced epithelial-to-mesenchymal transition. Zhang Q, Liu S, Parajuli KR, Zhang W, Zhang K, Mo Z, Liu J, Chen Z, Yang S, Wang AR, Myers L, You Z. Oncogene. 2017 Feb 2;36(5):687-699. doi: 10.1038/onc.2016.240. Epub 2016 Jul 4. PMID: 27375020 by NS
IHeparanase is expressed in adult human osteoarthritic cartilage and drives catabolic responses in primary chondrocytes. Gibor G, Ilan N, Journo S, Sharabi A, Dreyer J, Gertel S, Singh P, Menachem A, Snir N, Elkayam O, Vlodavsky I, Arad U. Osteoarthritis Cartilage. 2018 Aug;26(8):1110-1117. doi: 10.1016/j.joca.2018.05.013. Epub 2018 May 24. PMID: 29803826 by YT
Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression. Cohen-Kaplan V, Doweck I, Naroditsky I, Vlodavsky I, Ilan N. Cancer Res. 2008 Dec 15;68(24):10077-85. doi: 10.1158/0008-5472.CAN-08-2910. PMID: 19074873 by MT
Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells. Clements KE, Thakar T, Nicolae CM, Liang X, Wang HG, Moldovan GL. Nucleic Acids Res. 2018 Sep 28;46(17):8898-8907. doi: 10.1093/nar/gky657. PMID: 30032296 by RN
Angiotensin-(1-7), the product of ACE2 ameliorates NAFLD by acting through its receptor Mas to regulate hepatic mitochondrial function and glycolipid metabolism. Song LN, Liu JY, Shi TT, Zhang YC, Xin Z, Cao X, Yang JK. FASEB J. 2020 Dec;34(12):16291-16306. doi: 10.1096/fj.202001639R. Epub 2020 Oct 20. PMID: 33078906 by MH
Mutational and structural analyses of Caldanaerobius polysaccharolyticus Man5B reveal novel active site residues for family 5 glycoside hydrolases. Oyama T, Schmitz GE, Dodd D, Han Y, Burnett A, Nagasawa N, Mackie RI, Nakamura H, Morikawa K, Cann I. PLoS One. 2013 Nov 20;8(11):e80448. doi: 10.1371/journal.pone.0080448. eCollection 2013. PMID: 24278284 by RB
Fatty acid-induced nuclear translocation of heparanase uncouples glucose metabolism in endothelial cells. Wang F, Wang Y, Zhang D, Puthanveetil P, Johnson JD, Rodrigues B. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):406-14. doi: 10.1161/ATVBAHA.111.240770. Epub 2011 Nov 23. PMID: 22116097 by MY
Laquinimod Prevents Adipogenesis and Obesity by Down-Regulating PPAR-γ and C/EBPα through Activating AMPK. Wang G, Wu B, Zhang L, Cui Y, Zhang B, Wang H. ACS Omega. 2020 Sep 1;5(36):22958-22965. doi: 10.1021/acsomega.0c02525. eCollection 2020 Sep 15. PMID: 32954145 by YY
Syntenin-knock out reduces exosome turnover and viral transduction. Kashyap R, Balzano M, Lechat B, Lambaerts K, Egea-Jimenez AL, Lembo F, Fares J, Meeussen S, Kügler S, Roebroek A, David G, Zimmermann P. Sci Rep. 2021 Feb 18;11(1):4083. doi: 10.1038/s41598-021-81697-4. PMID: 33602969 by HY
Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity. Hauck S, Zager P, Halfter N, Wandel E, Torregrossa M, Kakpenova A, Rother S, Ordieres M, Räthel S, Berg A, Möller S, Schnabelrauch M, Simon JC, Hintze V, Franz S. Bioact Mater. 2021 Apr 30;6(12):4342-4359. doi: 10.1016/j.bioactmat.2021.04.026. eCollection 2021 Dec. PMID: 33997511 by KW
●2020年秋学期
A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells. Sung BH, von Lersner A, Guerrero J, Krystofiak ES, Inman D, Pelletier R, Zijlstra A, Ponik SM, Weaver AM. Nat Commun. 2020 Apr 29;11(1):2092. doi: 10.1038/s41467-020-15747-2. PMID: 32350252 by MH
Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer. Sun X, Zhan L, Chen Y, Wang G, He L, Wang Q, Zhou F, Yang F, Wu J, Wu Y, Xing J, He X, Huang Q. Signal Transduct Target Ther. 2018 Mar 30;3:8. doi: 10.1038/s41392-018-0011-z. eCollection 2018. PMID: 29610678 by JS
CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. Barkal AA, Brewer RE, Markovic M, Kowarsky M, Barkal SA, Zaro BW, Krishnan V, Hatakeyama J, Dorigo O, Barkal LJ, Weissman IL. Nature. 2019 Aug;572(7769):392-396. doi: 10.1038/s41586-019-1456-0. Epub 2019 Jul 31. PMID: 31367043 by XX
A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion. Labernadie A, Kato T, Brugués A, Serra-Picamal X, Derzsi S, Arwert E, Weston A, González-Tarragó V, Elosegui-Artola A, Albertazzi L, Alcaraz J, Roca-Cusachs P, Sahai E, Trepat X. Nat Cell Biol. 2017 Mar;19(3):224-237. doi: 10.1038/ncb3478. Epub 2017 Feb 20. PMID: 28218910 by RK
●2020年春学期（バーチャルセミナー）
Interferon-induced transmembrane proteins inhibit cell fusion mediated by trophoblast syncytins. Zani A, Zhang L, McMichael TM, Kenney AD, Chemudupati M, Kwiek JJ, Liu SL, Yount JS. J Biol Chem. 2019 Dec 27;294(52):19844-19851. doi: 10.1074/jbc.AC119.010611. PMID: 31735710 by YI, RK, NS
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA, Drosten C, Pöhlmann S. Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5. PMID: 32142651 by YT, MT, RN
Heparanase activates the syndecan-syntenin-ALIX exosome pathway. Roucourt B, Meeussen S, Bao J, Zimmermann P, David G. Cell Res. 2015 Apr;25(4):412-28. doi: 10.1038/cr.2015.29. Epub 2015 Mar 3. PMID: 25732677 by MH, RB, MY
Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury. Haeger SM, Liu X, Han X, McNeil JB, Oshima K, McMurtry SA, Yang Y, Ouyang Y, Zhang F, Nozik-Grayck E, Zemans RL, Tuder RM, Bastarache JA, Linhardt RJ, Schmidt EP. Am J Respir Cell Mol Biol. 2018 Sep;59(3):363-374. doi: 10.1165/rcmb.2017-0428OC. PMID: 29584451 by YY, HY, KW
Saponin 1 induces apoptosis and suppresses NF-κB-mediated survival signaling in glioblastoma multiforme (GBM). Li J, Tang H, Zhang Y, Tang C, Li B, Wang Y, Gao Z, Luo P, Yin A, Wang X, Cheng G, Fei Z. PLoS One. 2013 Nov 21;8(11):e81258. doi: 10.1371/journal.pone.0081258. eCollection 2013. PMID: 24278406 by SI
Induction of Human Lung Mast Cell Apoptosis by Granule Permeabilization: A Novel Approach for Targeting Mast Cells. Paivandy A, Sandelin M, Igelström H, Landelius P, Janson C, Melo FR, Pejler G. Front Immunol. 2017 Nov 27;8:1645. doi: 10.3389/fimmu.2017.01645. eCollection 2017. PMID: 29230220 by FI
Water Extract of Curcuma longa L. Ameliorates Non-Alcoholic Fatty LiverDisease. Mun J, Kim S, Yoon HG, You Y, Kim OK, Choi KC, Lee YH, Lee J, Park J, Jun W. Nutrients. 2019 Oct 21;11(10):2536. doi: 10.3390/nu11102536. PMID: 31640183 by YU
EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration. Aiello NM, Maddipati R, Norgard RJ, Balli D, Li J, Yuan S, Yamazoe T, Black T, Sahmoud A, Furth EE, Bar-Sagi D, Stanger BZ. Dev Cell. 2018 Jun 18;45(6):681-695.e4. doi: 10.1016/j.devcel.2018.05.027. PMID: 29920274 by TU
Bergamot Polyphenols Improve Dyslipidemia and Pathophysiological Features in a Mouse Model of Non-Alcoholic Fatty Liver Disease. Musolino V, Gliozzi M, Scarano F, Bosco F, Scicchitano M, Nucera S, Carresi C, Ruga S, Zito MC, Maiuolo J, Macrì R, Amodio N, Juli G, Tassone P, Mollace R, Caffrey R, Marioneaux J, Walker R, Ehrlich J, Palma E, Muscoli C, Bedossa P, Salvemini D, Mollace V, Sanyal AJ. Sci Rep. 2020 Feb 13;10(1):2565. doi: 10.1038/s41598-020-59485-3. PMID: 32054943 by SK
Heparanase-2 protects from LPS-mediated endothelial injury by inhibiting TLR4 signalling. Kiyan Y, Tkachuk S, Kurselis K, Shushakova N, Stahl K, Dawodu D, Kiyan R, Chichkov B, Haller H. Sci Rep. 2019 Sep 19;9(1):13591. doi: 10.1038/s41598-019-50068-5. PMID: 31537875 by DK
●2019年秋学期
Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4. Goodall KJ, Poon IK, Phipps S, Hulett MD. PLoS One. 2014 Oct 8;9(10):e109596. doi: 10.1371/journal.pone.0109596. PMID: 25295599 by JS
Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activity. Ramani VC, Yang Y, Ren Y, Nan L, Sanderson RD. J Biol Chem. 2011 Feb 25;286(8):6490-9. doi: 10.1074/jbc.M110.183277. Epub 2010 Dec 3. PMID: 21131364 by XX
Three Dimensional Mixed-Cell Spheroids Mimic Stroma-Mediated Chemoresistance and Invasive Migration in hepatocellular carcinoma. Khawar IA, Park JK, Jung ES, Lee MA, Chang S, Kuh HJ. Neoplasia. 2018 Aug;20(8):800-812. doi: 10.1016/j.neo.2018.05.008. Epub 2018 Jul 4. PMID: 29981501 by RK
Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection. Rojas-Quintero J, Wang X, Tipper J, Burkett PR, Zuñiga J, Ashtekar AR, Polverino F, Rout A, Yambayev I, Hernández C, Jimenez L, Ramírez G, Harrod KS, Owen CA. JCI Insight. 2018 Dec 20;3(24). pii: 99022. doi: 10.1172/jci.insight.99022. PMID: 30568032 by MW
Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentation. Sugimoto J, Schust DJ, Kinjo T, Aoki Y, Jinno Y, Kudo Y. Sci Rep. 2019 Dec 20;9(1):19502. doi: 10.1038/s41598-019-55933-x. PMID: 31862915 by MY
IL-8 promotes cell migration through regulating EMT by activating the Wnt/β-catenin pathway in ovarian cancer. Wen J, Zhao Z, Huang L, Wang L, Miao Y, Wu J. J Cell Mol Med. 2020 Jan;24(2):1588-1598. doi: 10.1111/jcmm.14848. Epub 2019 Dec 2. PMID: 31793192 by SF
NFκB activation in differentiating glioblastoma stem-like cells is promoted by hyaluronic acid signaling through TLR4. Ferrandez E, Gutierrez O, Segundo DS, Fernandez-Luna JL. Sci Rep. 2018 Apr 20;8(1):6341. doi: 10.1038/s41598-018-24444-6. PMID: 29679017 by SF
Hyaluronidase-4 is produced by mast cells and can cleave serglycin chondroitin sulfate chains into lower molecular weight forms. Farrugia BL, Mizumoto S, Lord MS, O'Grady RL, Kuchel RP, Yamada S, Whitelock JM. J Biol Chem. 2019 Jul 26;294(30):11458-11472. doi: 10.1074/jbc.RA119.008647. Epub 2019 Jun 7. PMID: 31175155 by HT
Oversulfated chondroitin sulfate binds to chemokines and inhibits stromal cell-derived factor-1 mediated signaling in activated T cells. Zhou ZH, Karnaukhova E, Rajabi M, Reeder K, Chen T, Dhawan S, Kozlowski S. PLoS One. 2014 Apr 9;9(4):e94402. doi: 10.1371/journal.pone.0094402. eCollection 2014. PMID: 24718687 by YT
●2019年春学期
Yin-Yang of IL-33 in Human Skin Mast Cells: Reduced Degranulation, but Augmented Histamine Synthesis through p38 Activation. Babina M, Wang Z, Franke K, Guhl S, Artuc M, Zuberbier T. J Invest Dermatol. 2019 Jan 23. pii: S0022-202X(19)30033-8. doi: 10.1016/j.jid.2019.01.013. [Epub ahead of print] PMID: 30684550 by FI and HT
HSulf-1 deficiency dictates a metabolic reprograming of glycolysis and TCA cycle in ovarian cancer. Mondal S, Roy D, Camacho-Pereira J, Khurana A, Chini E, Yang L, Baddour J, Stilles K, Padmabandu S, Leung S, Kalloger S, Gilks B, Lowe V, Dierks T, Hammond E, Dredge K, Nagrath D, Shridhar V. Oncotarget. 2015 Oct 20;6(32):33705-19. PMID: 26378042 by SF and MW
Lonicera caerulea Extract Attenuates Non-Alcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Hepatocytes and in High Fat Diet-Fed Mice. Park M, Yoo JH, Lee YS, Lee HJ. Nutrients. 2019 Feb 26;11(3). PMID: 30813654 by SI
PLIN2 Is Essential for Trophoblastic Lipid Droplet Accumulation and Cell Survival During Hypoxia. Bildirici I, Schaiff WT, Chen B, Morizane M, Oh SY, O'Brien M, Sonnenberg-Hirche C, Chu T, Barak Y, Nelson DM, Sadovsky Y. Endocrinology. 2018 Dec 1;159(12):3937-3949. PMID: 30351430 by MY supported by KT
Stepwise inhibition of T cell recruitment at post-capillary venules by orally active desulfated heparins in inflammatory arthritis. Al Faruque H, Kang JH, Hwang SR, Sung S, Alam MM, Sa KH, Nam EJ, Byun RY, Kang YM. PLoS One. 2017 Apr 18;12(4):e0176110. PMID: 28419144 by SI and YT
What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue. Qureshi-Baig K, Ullmann P, Rodriguez F, Frasquilho S, Nazarov PV, Haan S, Letellier E. PLoS One. 2016 Jan 8;11(1):e0146052. PMID: 26745821 by TU and RK
Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy. Shteingauz A, Boyango I, Naroditsky I, Hammond E, Gruber M, Doweck I, Ilan N, Vlodavsky I. Cancer Res. 2015 Sep 15;75(18):3946-57. PMID: 26249176 by DK and SF
●2018年秋学期
Heparanase regulates esophageal keratinocyte differentiation through nuclear translocation and heparan sulfate cleavage. Kobayashi M, Naomoto Y, Nobuhisa T, Okawa T, Takaoka M, Shirakawa Y, Yamatsuji T, Matsuoka J, Mizushima T, Matsuura H, Nakajima M, Nakagawa H, Rustgi A, Tanaka N. Differentiation. 2006 Jun;74(5):235-43. PMID: 16759289 by SI
Oral arginine supplementation protects female mice from the onset of non-alcoholic steatohepatitis. Sellmann C, Degen C, Jin CJ, Nier A, Engstler AJ, Hasan Alkhatib D, De Bandt JP, Bergheim I. Amino Acids. 2017 Jul;49(7):1215-1225. PMID: 28434046 by KI
Anti-obesity potential of enzymatic fragments of hyaluronan on high-fat diet-induced obesity in C57BL/6 mice. Park BG, Park YS, Park JW, Shin E, Shin WS. Biochem Biophys Res Commun. 2016 Apr 22;473(1):290-295. PMID: 27012203 by SO
Macrophages induce "budding" in aggressive human colon cancer subtypes by protease-mediated disruption of tight junctions. Trumpi K, Frenkel N, Peters T, Korthagen NM, Jongen JMJ, Raats D, van Grevenstein H, Backes Y, Moons LM, Lacle MM, Koster J, Zwijnenburg D, Borel Rinkes IHM, Kranenburg O. Oncotarget. 2018 Apr 13;9(28):19490-19507. doi: 10.18632/oncotarget.24626. eCollection 2018 Apr 13. PMID: 29731961 by RO
Increased expression of cell adhesion molecule 1 by mast cells as a cause of enhanced nerve-mast cell interaction in a hapten-induced mouse model of atopic dermatitis. Hagiyama M, Inoue T, Furuno T, Iino T, Itami S, Nakanishi M, Asada H, Hosokawa Y, Ito A. Br J Dermatol. 2013 Apr;168(4):771-8. doi: 10.1111/bjd.12108. PMID: 23106683 by FK
VEGF-C expression attributes the risk for lymphatic metastases to ovarian cancer patients. Kuerti S, Oliveira-Ferrer L, Milde-Langosch K, Schmalfeldt B, Legler K, Woelber L, Prieske K, Mahner S, Trillsch F. Oncotarget. 2017 Jun 27;8(26):43218-43227. doi: 10.18632/oncotarget.17978. PMID: 28591727 by AS
Expression of Concentrative Nucleoside Transporters (SLC28A) in the Human Placenta: Effects of Gestation Age and Prototype Differentiation-Affecting Agents. Jiraskova L, Cerveny L, Karbanova S, Ptackova Z, Staud F. Mol Pharm. 2018 Jul 2;15(7):2732-2741. doi: 10.1021/acs.molpharmaceut.8b00238. Epub 2018 May 25. PMID: 29782174 by HT
Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin. Ashkenazi A, Marsters SA, Capon DJ, Chamow SM, Figari IS, Pennica D, Goeddel DV, Palladino MA, Smith DH. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10535-9. PMID: 1660140 by MH
Chemical or genetic Pin1 inhibition exerts potent anticancer activity against hepatocellular carcinoma by blocking multiple cancer-driving pathways. Liao XH, Zhang AL, Zheng M, Li MQ, Chen CP, Xu H, Chu QS, Yang D, Lu W, Tsai TF, Liu H, Zhou XZ, Lu KP. Sci Rep. 2017 Mar 6;7:43639. doi: 10.1038/srep43639. PMID: 28262728 by JF
Chondroitin sulfate-E mediates estrogen-induced osteoanabolism. Koike T, Mikami T, Shida M, Habuchi O, Kitagawa H. Sci Rep. 2015 Mar 11;5:8994. doi: 10.1038/srep08994. PMID: 25759206 by RM
A small molecule inhibits virion attachment to heparan sulfate- or sialic acid-containing glycans. Colpitts CC, Schang LM. J Virol. 2014 Jul;88(14):7806-17. doi: 10.1128/JVI.00896-14. Epub 2014 Apr 30. PMID: 24789779 by TM
Topical skin treatment with Fab fragments of an allergen-specific IgG1 monoclonal antibody suppresses allergen-induced atopic dermatitis-like skin lesions in mice. Sae-Wong C, Mizutani N, Kangsanant S, Yoshino S. Eur J Pharmacol. 2016 May 15;779:131-7. doi: 10.1016/j.ejphar.2016.03.020. Epub 2016 Mar 9. PMID: 26970183 by NM
●2018年春学期
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Chantranupong L, Scaria SM, Saxton RA, Gygi MP, Shen K, Wyant GA, Wang T, Harper JW, Gygi SP, Sabatini DM. Cell. 2016 Mar 24;165(1):153-164. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10. PMID: 26972053 by YI
mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1. Moloughney JG, Kim PK, Vega-Cotto NM, Wu CC, Zhang S, Adlam M, Lynch T, Chou PC, Rabinowitz JD, Werlen G, Jacinto E. Mol Cell. 2016 Sep 1;63(5):811-26. doi: 10.1016/j.molcel.2016.07.015. Epub 2016 Aug 25. PMID: 27570073 by SF
Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice. Lerner I, Zcharia E, Neuman T, Hermano E, Rubinstein AM, Vlodavsky I, Elkin M. Cell Mol Life Sci. 2014 Jun;71(12):2347-2357. doi: 10.1007/s00018-013-1496-9. Epub 2013 Oct 30. PMID: 24169805 by MI
Heparanase is a host enzyme required for herpes simplex virus-1 release from cells. Hadigal SR, Agelidis AM, Karasneh GA, Antoine TE, Yakoub AM, Ramani VC, Djalilian AR, Sanderson RD, Shukla D. Nat Commun. 2015 Apr 27;6:6985. doi: 10.1038/ncomms7985. PMID: 25912399 by MU
Efficient sorting of TNF-alpha to rodent mast cell granules is dependent on N-linked glycosylation. Olszewski MB, Trzaska D, Knol EF, Adamczewska V, Dastych J. Eur J Immunol. 2006 Apr;36(4):997-1008. PMID: 16541468 by YS
Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545. Abassi Z, Hamoud S, Hassan A, Khamaysi I, Nativ O, Heyman SN, Muhammad RS, Ilan N, Singh P, Hammond E, Zaza G, Lupo A, Onisto M, Bellin G, Masola V, Vlodavsky I, Gambaro G. Oncotarget. 2017 May 23;8(21):34191-34204. doi: 10.18632/oncotarget.16573. PMID: 28388547 by NS
Epigallocatechin-3-gallate inhibits adipogenesis through down-regulation of PPARγ and FAS expression mediated by PI3K-AKT signaling in 3T3-L1 cells. Wu M, Liu D, Zeng R, Xian T, Lu Y, Zeng G, Sun Z, Huang B, Huang Q. Eur J Pharmacol. 2017 Jan 15;795:134-142. doi: 10.1016/j.ejphar.2016.12.006. Epub 2016 Dec 7. PMID: 27940057 by SS
Pin1-mediated Modification Prolongs the Nuclear Retention of β-Catenin in Wnt3a-induced Osteoblast Differentiation. Shin HR, Islam R, Yoon WJ, Lee T, Cho YD, Bae HS, Kim BS, Woo KM, Baek JH, Ryoo HM. J Biol Chem. 2016 Mar 11;291(11):5555-65. doi: 10.1074/jbc.M115.698563. Epub 2016 Jan 6. PMID: 26740630 by MN
Syndecan-1 Attenuates Lung Injury during Influenza Infection by Potentiating c-Met Signaling to Suppress Epithelial Apoptosis. Brauer R, Ge L, Schlesinger SY, Birkland TP, Huang Y, Parimon T, Lee V, McKinney BL, McGuire JK, Parks WC, Chen P. Am J Respir Crit Care Med. 2016 Aug 1;194(3):333-44. doi: 10.1164/rccm.201509-1878OC. PMID: 26959387 by FA
Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters. Cheung KJ, Padmanaban V, Silvestri V, Schipper K, Cohen JD, Fairchild AN, Gorin MA, Verdone JE, Pienta KJ, Bader JS, Ewald AJ. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E854-63. doi: 10.1073/pnas.1508541113. Epub 2016 Feb 1. PMID: 26831077 by AK
TNF trafficking to human mast cell granules: mature chain-dependent endocytosis. Olszewski MB, Groot AJ, Dastych J, Knol EF. J Immunol. 2007 May 1;178(9):5701-9. PMID: 17442953 by SS
Tumor suppressor p53 regulates heparanase gene expression. Baraz L, Haupt Y, Elkin M, Peretz T, Vlodavsky I. Oncogene. 2006 Jun 29;25(28):3939-47. Epub 2006 Feb 13. PMID: 16474844 by SS
Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity. Levy-Adam F, Feld S, Cohen-Kaplan V, Shteingauz A, Gross M, Arvatz G, Naroditsky I, Ilan N, Doweck I, Vlodavsky I. J Biol Chem. 2010 Sep 3;285(36):28010-9. doi: 10.1074/jbc.M110.116384. Epub 2010 Jun 24. PMID: 20576607 by AF
Novel Intraperitoneal Treatment With Non-Thermal Plasma-Activated Medium Inhibits Metastatic Potential of Ovarian Cancer Cells. Nakamura K, Peng Y, Utsumi F, Tanaka H, Mizuno M, Toyokuni S, Hori M, Kikkawa F, Kajiyama H. Sci Rep. 2017 Jul 20;7(1):6085. doi: 10.1038/s41598-017-05620-6. PMID: 28729634 by RY
Expression of hypoxia-inducible factor-1 by trophectoderm cells in response to hypoxia and epidermal growth factor. Jeong W, Bazer FW, Song G, Kim J. Biochem Biophys Res Commun. 2016 Jan 8;469(2):176-82. doi: 10.1016/j.bbrc.2015.11.091. Epub 2015 Nov 24. PMID: 26620226 by YY
GATA3 interacts with and stabilizes HIF-1α to enhance cancer cell invasiveness. Lin MC, Lin JJ, Hsu CL, Juan HF, Lou PJ, Huang MC. Oncogene. 2017 Jul 27;36(30):4243-4252. doi: 10.1038/onc.2017.8. Epub 2017 Mar 6. Erratum in: Oncogene. 2017 Jun 12;:. PMID: 28263977 by SI KI HT
Heparanase Mediates Intestinal Inflammation and Injury in a Mouse Model of Sepsis. Chen S, He Y, Hu Z, Lu S, Yin X, Ma X, Lv C, Jin G. J Histochem Cytochem. 2017 Apr;65(4):241-249. doi: 10.1369/0022155417692536. Epub 2017 Feb 7. PMID: 28170292 by SO AS MH
Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α. Han HJ, Kwon N, Choi MA, Jung KO, Piao JY, Ngo HK, Kim SJ, Kim DH, Chung JK, Cha YN, Youn H, Choi BY, Min SH, Surh YJ. PLoS One. 2016 Jan 19;11(1):e0147038. doi: 10.1371/journal.pone.0147038. eCollection 2016. Erratum in: PLoS One. 2016;11(3):e0151517. PMID: 26784107 by RO JF TM
Processing of macromolecular heparin by heparanase. Gong F, Jemth P, Escobar Galvis ML, Vlodavsky I, Horner A, Lindahl U, Li JP. J Biol Chem. 2003 Sep 12;278(37):35152-8. Epub 2003 Jul 1. PMID: 12837765 by FK RM NM
●2017年秋学期 論文紹介はなし
●2017年春学期
The protein level and transcription activity of activating transcription factor 1 is regulated by prolyl isomerase Pin1 in nasopharyngeal carcinoma progression. Huang GL, Liao D, Chen H, Lu Y, Chen L, Li H, Li B, Liu W, Ye C, Li T, Zhu Z, Wang J, Uchida T, Zou Y, Dong Z, He Z. Cell Death Dis. 2016 Dec 29;7(12):e2571. doi: 10.1038/cddis.2016.349. PMID: 28032861 by HK
TASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer. van Geldermalsen M, Wang Q, Nagarajah R, Marshall AD, Thoeng A, Gao D, Ritchie W, Feng Y, Bailey CG, Deng N, Harvey K, Beith JM, Selinger CI, O'Toole SA, Rasko JE, Holst J. Oncogene. 2016 Jun 16;35(24):3201-8. doi: 10.1038/onc.2015.381. Epub 2015 Oct 12. PMID: 26455325 by MS
PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. Dredge K, Hammond E, Handley P, Gonda TJ, Smith MT, Vincent C, Brandt R, Ferro V, Bytheway I. Br J Cancer. 2011 Feb 15;104(4):635-42. doi: 10.1038/bjc.2011.11. Epub 2011 Feb 1. PMID: 21285983 by MI MU MN
Cell surface localization of heparanase on macrophages regulates degradation of extracellular matrix heparan sulfate. Sasaki N, Higashi N, Taka T, Nakajima M, Irimura T. J Immunol. 2004 Mar 15;172(6):3830-5. PMID: 15004189 by YS SS NS
Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells. McKenzie E, Young K, Hircock M, Bennett J, Bhaman M, Felix R, Turner P, Stamps A, McMillan D, Saville G, Ng S, Mason S, Snell D, Schofield D, Gong H, Townsend R, Gallagher J, Page M, Parekh R, Stubberfield C. Biochem J. 2003 Jul 15;373(Pt 2):423-35. PMID: 12713442 by FA AK AF
Heparanase expression in B16 melanoma cells and peripheral blood neutrophils before and after extravasation detected by novel anti-mouse heparanase monoclonal antibodies. Komatsu N, Waki M, Sue M, Tokuda C, Kasaoka T, Nakajima M, Higashi N, Irimura T. J Immunol Methods. 2008 Feb 29;331(1-2):82-93. Epub 2007 Dec 27. PMID: 18162185 by HO SS SS
The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression. Singh P, Blatt A, Feld S, Zohar Y, Saadi E, Barki-Harrington L, Hammond E, Ilan N, Vlodavsky I, Chowers Y, Half E. Neoplasia. 2017 Mar;19(3):175-184. doi: 10.1016/j.neo.2016.12.001. Epub 2017 Jan 29. PMID: 28147305 by RY SY YY
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