発表論文
Shogo Kamo*, Motoi Suzuki, Kazuyuki Sugita*, "Total Syntheses of Ganodilactone and Related Ganoderma-Derived Meroterpenoid Dimers via Intramolecular Vinylogous Michael Addition", Org. Lett. 2025, 27, 7488−7493.
Shogo Kamo*, Kazuki Hori, Kazuyuki Sugita*, "Chemoselective One-pot Cleavage and Oxidation of Silyl Ethers into Corresponding Carbonyl Compounds Using IBX and Acid Catalyst", Org. Biomol. Chem. 2024, doi.org/10.1039/D4OB00858H.
Kazuki Hori, Shunsuke Onuma, Yuta Nakazato, Tomoya Mashiko, Akihiko Kasamatsu, Akinobu Matsuzawa, Shogo Kamo, Kazuyuki Sugita*, "Total syntheses of fungal isoindolinones corallocins B and C", J. Heterocycl. Chem. 2024, doi.org/10.1002/jhet.4853.
Hiroto Aihara, Daisuke Kounai, Akihiko Kasamatsu, Junya Shiraiwa, Akinobu Matsuzawa, Shogo Kamo, and Kazuyuki Sugita*,"Protecting Group-Free Total Synthesis of (−)-Boscartin H", J. Org. Chem. 2024, 89, 8924-8930.
Naoki Kokaji, Naru Ishikura, Akinobu Matsuzawa, Shogo Kamo, Kazuyuki Sugita*,"Total synthesis of 14-membered ring β-resorcylic acid lactone (+)-monocillin II", Org. Biomol. Chem. 2024, 22,2056-2058.
Tomoya Mashiko, Yuta Shingai, Jun Sakai, Shinya Adachi, Akinobu Matsuzawa, Shogo Kamo, and Kazuyuki Sugita*, "Enantioselective Total Syntheses of (+)-Ganocin A and (−)-Cochlearol B", Org. Lett. 2023, 25, 8382−8386. 本論文は、Wiley-VCH社の論文紹介サイトChemistry Europe 「ChemistryView」において紹介された。
Eiji Nagata, Hisaaki Sakate, Takaharu Okada, Shinya Adachi, Shogo Kamo, Akinobu Matsuzawa, and Kazuyuki Sugita*, “Synthesis of (±)-5-epi-Vetiverianine A via an Oxidative Cyclization Approach”, SYNTHESIS 2023, 55, 663-669. 本論文は、SYNTHESIS誌issue 04, 2023において表紙を飾った。
Shogo Kamo, Akihiko Kasamatsu, Junya Shiraiwa, Akinobu Matsuzawa, and Kazuyuki Sugita*, “Protecting-Group-Free Total Synthesis of (−)-Boscartin A in 3 steps from (−)-Boscartin F via Wharton Reaction”, Eur. J. Org. Chem. 2022, e202201366
Tomoya Mashiko, Eiji Nagata, Hisaaki Sakate, Shogo Kamo, and Kazuyuki Sugita*, “Total Synthesis of (+)-ent-Vetiverianine A via Lewis Acid-Mediated Cyclization”, Org. Chem. Front. 2022, 9, 6849-6852.
Kazuki Hori, Shogo Kamo and Kazuyuki Sugita*, Total syntheses of Ganoderma-derived meroterpenoids, (−)-oregonensin A, (−)-chizhine E, (−)-applanatumol U, and (−)-ent-fornicin A, Org. Biomol. Chem. 2022, 20, 9138-9141.
Shogo Kamo, Hitomi Kurosawa, Akinobu Matsuzawa, and Kazuyuki Sugita*, “Total Synthesis of (−)-Lamellodysidine A via an Intramolecular Diels–Alder Reaction”, Org. Lett. 2022, 24, 921-923. 本論文は、Synfacts誌（Synfacts 2022, 18, 0347.）にて紹介された。
Tomoya Mashiko, Yuta Shingai, Jun Sakai, Shogo Kamo, Shinya Adachi, Akinobu Matsuzawa, and Kazuyuki Sugita*, “Total Synthesis of Cochlearol B via Intramolecular [2+2] Photocycloaddition”, Angew. Chem. Int. Ed. 2021, 60, 24484 –24487. 本論文は、Angew. Chem. Int. Ed.誌 one of the most downloaded paper during its first 12 months of publication in an issue between 1 January 2021 – 31 December 2021となった。また本論文は、Synfacts誌（Synfacts 2021, 17, 1315.）にて紹介された。
Rintaro Matsuo, Ayumu Watanabe, Shogo Kamo, Akinobu Matsuzawa and Kazuyuki Sugita*, “Total syntheses of (±)-penicibilaenes A and B via intramolecular aldol condensation”, Org. Chem. Front. 2021, 8, 6063–6066.
Motoi Kuwabara, Ami Matsuo, Shogo Kamo, Akinobu Matsuzawa, Kazuyuki Sugita*, “Stereoselective Convergent Synthesis of Carbon Skeleton of Cotylenin A Aglycone”, Synthesis 2021, 53, 2092–2102. 本論文は、Synthsis誌においてNews Articleとして紹介された。
Tomoya Mashiko, Yuta Nakazato, Yuta Katsumura, Akihiko Kasamatsu, Shinya Adachi, Shogo Kamo, Akinobu Matsuzawa and Kazuyuki Sugita*, “Convergent total synthesis of corallocin A”, Org. Biomol. Chem. 2021, 19, 5127–5132.
Tomohisa Mori, Yoshinori Takemura, Takamichi Arima, Yoshiyuki Iwase, Michiko Narita, Kanako Miyano, Yusuke Hamada, Yukari Suda, Akinobu Matsuzawa, Kazuyuki Sugita, Shoki Matsumura, Shigeru Sasaki, Takayasu Yamauchi, Kimio Higashiyama, Yasuhito Uezono, Mitsuaki Yamazaki, Naoko Kuzumaki, Minoru Narita, “Further investigation of the rapid-onset and short-duration action of the G protein-biased m-ligand oliceridine”, Biochem. Biophys. Res. Commun. 2021, 534, 988–994.
Rintaro Matsuo, Ayumu Miyashita, Motoi Kuwabara, Shinya Adachi, Akinobu Matsuzawa, Kazuyuki Sugita*, “Concise Diastereoselective Total Synthesis of (±)-Parvistemonine A”, Synlett 2020, 31, 1800–1804. 本論文は、Synlett誌においてNews Articleとして紹介された。
Naoto Okutomi, Akinobu Matsuzawa, and Kazuyuki Sugita*, “Diastereoselective Total Syntheses of (±)-Caseabalansin A and (±)-18-Epicaseabalansin A via Intramolecular Robinson-type Annulation”, Chem. Asian J. 2019, 14, 2077 – 2081. 本論文は、Chem. Asian J.誌においてVery Important Paperに選出された。
Akihiko Kasamatsu, Motoi Kuwabara, Akinobu Matsuzawa, Kazuyuki Sugita*, “Total synthesis of granulodione”, Tetrahedron Lett. 2019, 60, 113–114.
Kazuyuki Sugita*, “Quinolone synthetic antibacterial agent gold standard for antibacterial agents created by researchers”, Kagaku to Kyoiku 2019, 67(11), 554-557.
Akinobu Matsuzawa, Junya Shiraiwa, Akihiko Kasamatsu, and Kazuyuki Sugita*, “Enantioselective, Protecting-Group-Free Total Synthesis of Boscartin F”, Org. Lett. 2018, 20, 1031−1033.
Mayuko Iwata, Motoi Kuwabara, Akinobu Matsuzawa, and Kazuyuki Sugita*, “Facile Total Synthesis of (+)-Spinoxazine B”, Chem. Pharm. Bull. 2018, 66, 1196–1198. 本論文は、Chem. Pharm. Bull.誌において、Highlighted Paper selected by Editor-in Chiefに選抜された。
Tomohisa Mori, Naoko Kuzumaki, Takamichi Arima, Michiko Narita, Ryunosuke Tateishi, Takashige Kondo, Yusuke Hamada, Hirotsugu Kuwata, Miho Kawata, Mitsuaki Yamazaki, Kazuyuki Sugita, Akinobu Matsuzawa, Kanae Baba, Takayasu Yamauchi, Kimio Higashiyama, Miki Nonaka, Kanako Miyano, Yasuhito Uezono, Minoru Narita, “Usefulness for the combination of G protein- and B-arrestin-biased ligands of m-opioid receptors: Prevention of antinociceptive tolerance”, Molecular Pain 2017, 13, 1–9.
Akinobu Matsuzawa, Akihiko Kasamatsu, Kazuyuki Sugita*, “Reductive cyclization strategy for construction of the highly oxygenated CD ring system of aconitine”, Tetrahedron Lett. 2016, 57, 4585–4587.
Akinobu Matsuzawa*, Shiho Takeuchi, Kazuyuki Sugita*, “Iodoalkyne-Based Catalyst-Mediated Activation of Thioamides through Halogen Bonding”, Chem Asian J. 2016, 11, 2863–2866.
Taki Sakai, Yotaro Matsumoto, Minoru Ishikawa, Kazuyuki Sugita, Yuichi Hashimoto, Nobuhiko Wakai, Akio Kitao, Era Morishita, Chikashi Toyoshima, Tomoatsu Hayashi, Tetsu Akiyama, “Design, synthesis and structure–activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton”, Bioorg. Med. Chem. 2015, 23, 328-339.
Kaori Endo-Umeda, Kaori Yasuda, Kazuyuki Sugita, Akira Honda, Miho Ohta, Minoru Ishikawa, Yuichi Hashimoto, Toshiyuki Sakaki, Makoto Makishima, “7-Dehydrocholesterol metabolites produced by sterol 27-hydroxylase (CYP27A1) modulate liver X receptor activity”, J. Steroid Biochem. Mol. Biol. 2014, 140, 7-16.
Risako Kon, Nobutomo Ikarashi, Chika Nagoya, Tomoko Takayama, Yoshiki Kusunoki, Makoto Ishii, Harumi Ueda, Wataru Ochiai, Yoshiaki Machida, Kazuyuki Sugita, Kiyoshi Sugiyama, “Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract”, J. Ethnopharmacol. 2014, 152, 190-200.
Masanori Ichikawa, Masami Ohtsuka, Hitoshi Ohki, Masahiro Ota, Noriyasu Haginoya, Masao Itoh, Yoshihiro Shibata, Kazuyuki Sugita, Yutaka Ishigai, Koji Terayama, Akira Kanda, Hiroyuki Usui, “Discovery of DF-461, a Potent Squalene Synthase Inhibitor”, ACS Med. Chem. Lett. 2013, 4, 932-936.
Keisuke Maruyama, Masaharu Nakamura, Shusuke Tomoshige, Kazuyuki Sugita, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa, “Structure–activity relationships of bisphenol A analogs at estrogen receptors (ERs): Discovery of an ERα-selective antagonist”, Bioorg. Med. Chem. Lett. 2013, 23, 4031-4036.
Masanori Ichikawa, Masami Ohtsuka, Hitoshi Ohki, Noriyasu Haginoya, Masao Itoh, Kazuyuki Sugita, Hiroyuki Usui, Makoto Suzuki, Koji Terayama, Akira Kanda, “Discovery of novel tricyclic compounds as squalene synthase inhibitors”, Bioorg. Med. Chem. 2012, 20, 3072-3093.
Mohammed T.A. Salim, Hiroshi Aoyama, Kazuyuki Sugita, Kouichi Watashi, Takaji Wakita, Takayuki Hamasaki, Mika Okamoto, Yasuo Urata, Yuichi Hashimoto, Masanori Baba: Potent and selective inhibition of hepatitis C virus replication by novel phenanthridinone derivatives, Biochem. Biophys. Res. Commun., 415, 714-719 (2011).
Ichikawa, Masanori; Yokomizo, Aki; Itoh, Masao; Haginoya, Noriyasu; Kazuyuki Sugita; Usui, Hiroyuki; Terayama, Koji; Kanda, Akira: Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: Novel, highly potent and orally efficacious squalene synthase inhibitors, Bioorg. Med. Chem., 19(17), 5207-5224 (2011).
Tomomi Noguchi-Yachide, Kazuyuki Sugita and Yuichi Hashimoto: Estrogen receptor α/β ligands derived from thalidomide, Heterocycles, 83(9), 2137-2147 (2011).
Kazunori Motoshima, Minoru Ishikawa, Yuichi Hashimoto, and Kazuyuki Sugita: Inhibition of restriction enzymes EcoRI and, BamHI and HindIII by phenetylphenyl phthalimides Derived from thalidomide, Chem. Pharm. Bull., 59(7), 880-884 (2011).
Kazunori Motoshima, Minoru Ishikawa, Yuichi Hashimoto, Kazuyuki Sugita: Peroxisome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists: Relationship between absolute configuration and subtype selectivity, Bioorg. Med. Chem., 19(10), 3156-3172 (2011).
Kazunori Motoshima, Kazuyuki Sugita, Yuichi Hashimoto, Minoru Ishikawa: Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related α-glucosidase inhibitors and liver X receptor antagonists, Bioorg. Med. Chem. Lett., 21(10), 3041-3045 (2011).
Hiroshi Aoyama, Kazuyuki Sugita, Masahiko Nakamura, Atsushi Aoyama, Mohammed T. Salim, Mika Okamoto, Masanori Baba, Yuichi Hashimoto: Fused heterocyclic amido compounds as anti-hepatitis C virus agents, Bioorg. Med. Chem., 19(8), 2675-2687 (2011).
Kazunori Motoshima, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto, Kazuyuki Sugita: Further application of the multi-template approach for creation of biological response modifiers: discovery of a new class of multifunctional anti-diabetic agents, Heterocycles, 82(2), 1083-1101 (2011).
Masanori Ichikawa, Aki Yokomizo, Masao Itoh, Kazuyuki Sugita, Hiroyuki Usui, Hironari Shimizu, Makoto Suzuki, Koji Terayama, Akira Kanda: Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors, Bioorg. Med. Chem., 19(6), 1930-1949 (2011).
Nemoto, T.; Yamamoto, N.; Watanabe, A.; Fujii, H.; Hasebe, K.; Nakajima, M.; Mochizuki, H.; Nagase, H.; Synthesis of 6,14-epoxymorphinan derivatives and their pharmacologies., Bioorg. Med. Chem., 19, 1205-1221 (2011).
Keisuke Maruyama, Tomomi Noguchi-Yachide, Kazuyuki Sugita, Yuichi Hashimoto, Minoru Ishikawa: Novel selective anti-androgens with a diphenylpentane skeleton, Bioorg. Med. Chem. Lett., 20(22), 6661-6666 (2010).
Tuma Iwai, Hitoshi Takahashi, Dai Hatakeyama, Kazunori Motoshima, Minoru Ishikawa, Kazuyuki Sugita, Yuichi Hashimoto, Yuichi Harada, Shigeru Itamura, Takao Odagiri, Masato Tashiro, Yoshihisa Sei, Kentaro Yamaguchi, Takashi Kuzuhara: Anti-influenza activity of phenethylphenylphthalimide analogs derived from thalidomide, Bioorg. Med. Chem., 18(14), 5379-5390 (2010).
Takashi Misawa, Mokammed T. A. Salim, Mika Okamoto, Masanori Baba, Hiroshi Aoyama, Yuichi Hashimoto, Kazuyuki Sugita: Synthesis and anti-hepatitis C virus activity of morpholino triazine derivatives, Heterocycles, 81(6), 1419-1426 (2010).
特許
Baba, Masanori; Hashimoto, Yuichi; Aoyama, Hiroshi; Sugita, Kazuyuki; Nakamura, Masahiko; Aoyama, Atsushi; Urata, Yasuo: Preparation of phenanthridin-6(5H)-one compounds as therapeutic agents for hepatitis C, PCT Int. Appl. (2011), 120pp. WO 2011093483 A1 20110804.
Nakayama, Kiyoshi; Sugita, Kazuyuki; Setoguchi, Masaki; Tominaga, Yuichi; Saito, Masaki; Odagiri, Takashi: Preparation of morpholinopurine compounds for inhibiting PI3K and/or mTOR, Jpn. Kokai Tokkyo Koho (2011), 225pp. JP 2011236198 A 20111124.
Nakayama, Kiyoshi; Sugita, Kazuyuki; Setoguchi, Masaki; Tominaga, Yuichi; Saitou, Masanori; Odagiri, Takashi: Preparation of morpholinopurine compounds as PI3K and/or mTOR inhibitors, PCT Int. Appl. (2010), 335pp. WO2010044401 A1 20100422.
Sugita, Kazuyuki; Otsuka, Masaki; Oki, Hitoshi; Haginoya, Noriyasu; Ichikawa, Masanori; Ota, Masahiro; Shibata, Norihiro: Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors, Jpn. Kokai Tokkyo Koho (2010), 277pp. JP2010150142 A 20100708.
Sugita, Kazuyuki; Ito, Masao; Ichikawa, Masanori: Preparation of tricyclic aryl compounds as squalene synthase inhibitors, Jpn. Kokai Tokkyo Koho (2010), 116pp. JP2010120929 A 20100603.
Sugita, Kazuyuki; Otsuka, Masaki; Oki, Hitoshi; Haginoya, Noriyasu; Ichikawa, Masanori; Ota, Masahiro; Shibata, Norihiro: Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors, Jpn. Kokai Tokkyo Koho (2010), 154pp. JP2010100566 A 20100506.
Sugita, Kazuyuki; Haginoya, noriyasu: Preparation of substituted tricyclic heteroaryl compound as squalene and cholesterol synthetase inhibitors, PCT Int. Appl. (2010), 139pp. WO2010041726 A1 20100415.