研究成果は、国内外の学会（日本薬学会、日本薬理学会、日本平滑筋学会、日本循環薬理学会、日本心脈管作動物質学会、日本糖尿病学会、Experimental Biology、High Blood Pressure Research　等）にて発表しつつ、下記の論文にて報告しています。

（リストの該当論文末に　インパクトファクター (IF)：数値　を付記してあります。）

[2017] Taguchi K, Hida M, Narimatsu H, Matsumoto T, Kobayashi T. Glucose and angiotensin II-derived endothelial extracellular vesicles regulate endothelial dysfunction via ERK1/2 activation. Pflugers Arch. 2017 Feb;469(2):293-302. IF:3.7

[2017] Matsumoto T, Watanabe S, Kobayashi S, Ando M, Taguchi K, Kobayashi T. Age-related reduction of contractile responses to urotensin II is seen in aortas from Wistar rats but not from type 2 diabetic Goto-Kakizaki rats. Rejuvenation Research. 2016 Dec 20. [Epub ahead of print] PubMed PMID: 27841739. IF:3.3

[2017] Watanabe S, Matsumoto T,Taguchi K, Kobayashi T. Relationship between PDK1 and contraction in carotid arteries in Goto-Kakizaki rat, a spontaneous type 2 diabetic animal model. Can J Physiol Pharmacol. 2017 Jan 24:1-4. doi: 10.1139/cjpp-2016-0372. IF:1.7

[2016] Kubota T, Kubota N, Sato H, Inoue M, Kumagai H, Iwamura T, Takamoto I, Kobayashi T, Moroi M, Terauchi Y, Tobe K, Ueki K, Kadowaki T. Pioglitazone Ameliorates Smooth Muscle Cell Proliferation in Cuff-Induced Neointimal Formation by Both Adiponectin-Dependent and -Independent Pathways. Sci Rep2016 Oct 5;6:34707. doi: 10.1038/srep34707 IF:5.2

[2016]McCarthy CG, Wenceslau CF, Goulopoulou S, Ogbi S, Matsumoto T, Webb RC. Autoimmune therapeutic chloroquine lowers blood pressure and improves endothelial function in spontaneously hypertensive rats. Pharmacol Res.2016 Sep 14. pii: S1043-6618(16)30369-3. doi: 10.1016/j.phrs.2016.09.008. IF: 4.8

[2016]Watanabe S, Matsumoto T, Ando M, Kobayashi S, Iguchi M, Taguchi K, Kobayashi T. Effect of long-term diabetes on serotonin-mediated contraction in carotid arteries from streptozotocin-induced diabetic male and female rats.Biol Pharm Bull.2016;39(10):1723-1727. PubMed PMID: 27725452. IF: 1.6

[2016] McCarthy CG, Wenceslau CF, Goulopoulou S, Baban B, Matsumoto T, Webb RC. Chloroquine Suppresses the Development of Hypertension in Spontaneously Hypertensive Rats Am J Hypertens. 2016 Sep 13. pii: hpw113. [Epub ahead of print] IF:3.2

[2016] Matsumoto T, Ando M, Watanabe S, Iguchi M, Nagata M, Kobayashi S, Taguchi K, Kobayashi T. Tunicamycin-Induced Alterations in the Vasorelaxant Response in Organ-Cultured Superior Mesenteric Arteries of Rats Biol Pharm Bull. 2016;39(9):1475-81 IF: 1.6

[2016] Watanabe S, Matsumoto T, Ando M, Kobayashi S, Iguchi M, Taguchi K, Kobayashi T. A Comparative Study of Vasorelaxant Effects of ATP, ADP, and Adenosine on the Superior Mesenteric Artery of SHR. Biol Pharm Bull. 2016;39(8):1374-80. doi: 10.1248/bpb.b16-00260.PMID: 27476946 IF: 1.6

[2016] Watanabe S, Matsumoto T, Ando M, Adachi T, Kobayashi S, Iguchi M, Takeuchi M, Taguchi K, Kobayashi T. Multiple activation mechanisms of serotonin-mediated contraction in the carotid arteries obtained from spontaneously hypertensive rats. Pflugers Arch2016 Jul;468(7):1271-82 IF:3.7

[2016] Ishida K, Taguchi K, Hida M, Watanabe S, Kawano K, Matsumoto T,Hattori Y, Kobayashi T. Circulating microparticles from diabetic rats impair endothelial function and regulate endothelial protein expression. Acta Physiol (Oxf). 2016 Feb;216(2):211-20. doi: 10.1111/apha.12561. Epub 2015 Aug 20. PubMed PMID: 26235826. IF: 4.4

[2016] Goulopoulou S, Wenceslau CF, McCarthy CG, Matsumoto T, Webb RC. Exposure to Stimulatory CpG Oligonucleotides During Gestation induces Maternal Hypertension and Excess Vasoconstriction in Pregnant Rats. Am J Physiol Heart Circ Physiol.2016 Apr 15;310(8):H1015-25. doi: 10.1152/ajpheart.00834.2015. Epub 2016 Feb 12. PMID: 26873968 IF: 3.838

[2016] Matsumoto T, Watanabe S, Ando M, Yamada K, Iguchi M, Taguchi K, Kobayashi T. Diabetes and age-related differences in vascular function of renal artery: Possible involvement of endoplasmic reticulum stress. Rejuvenation Res. 2016 Feb;19(1):41-52. doi: 10.1089/rej.2015.1662.PMID: 26234558. IF:3.3

[2016] Lima VV, Giachini FF, Matsumoto T, Li W, Bressan AF, Chawla D, Webb RC, Ergul A, Tostes RC. High fat diet increases O-GlcNAc levels in cerebral arteries: a link to vascular dysfunction associated with hyperlipidemia/obesity? Clin Sci (Lond). 2016 Feb 29. pii: CS20150777. [Epub ahead of print] PMID: 26929437. IF: 5.598

[2016] Taguchi K, Hida M, Hasegawa M, Matsumoto T, Kobayashi T. Dietary polyphenol morin rescues endothelial dysfunction in a diabetic mouse model by activating the Akt/eNOS pathway, Mol Nutr Food Res. 2016 Mar;60(3):580-8. doi: 10.1002/mnfr.201500618. Epub 2015 Dec 29. PMID: 26626705 IF:4.6

[2016] Watanabe S, Matsumoto T, Oda M, Yamada K, Takagi J, Taguchi K, Kobayashi T. Insulin augments serotonin-induced contraction via activation of the IR/PI3K/PDK1 pathway in the rat carotid artery. Pflugers Arch. 2016 Apr;468(4):667-77. doi: 10.1007/s00424-015-1759-4. Epub 2015 Nov 17. PMID: 26577585 IF: 4.1

[2016] Matsumoto T, Watanabe S, Iguchi M, Ando M, Oda M, Nagata M, Yamada K, Taguchi K, Kobayashi T. Mechanisms underlying enhanced noradrenaline-induced femoral arterial contraction of spontaneously hypertensive rats: Involvement of endothelium-derived factors and cyclooxygenase-derived prostanoids. Biol Pharm Bull. 2016;39(3):384-93. doi: 10.1248/bpb.b15-00821. PMID: 26934930 IF: 1.8

[2015] 池内由里, 小林恒雄, 田口久美子, 大西　啓, 1型糖尿病モデルマウスにおけるポリフェノールの脂質過酸化抑制効果, 日本健康医療学会雑誌. 2016 3(2), 35-42

[2015] 池内由里, 小林恒雄, 田口久美子, 大西　啓, シス型およびトランス型脂肪酸における脂質過酸化とポリフェノールによる脂質過酸化抑制効果, 日本健康医療学会雑誌. 2016 3(2), 27-34

[2015] Ferreira NS, Cau SB, Silva MA, Manzato CP, Mestriner FL, Matsumoto T, Carneiro FS, Tostes RC. Diabetes impairs the vascular effects of aldosterone mediated by G protein-coupled estrogen receptor activation.  Front Pharmacol. 2015 Mar 2;6:34. doi: 10.3389/fphar.2015.00034. eCollection 2015. IF: 3.8

[2015] McCarthy CG, Wenceslau CF, Goulopoulou S, Ogbi S, Baban B, Sullivan JC, Matsumoto T, Webb RC. Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats.   Cardiovasc Res.2015 Jul 1;107(1):119-30. doi: 10.1093/cvr/cvv137. Epub 2015 Apr 24. IF: 5.9

[2015] Goulopoulou S, Hannan JL, Matsumoto T, Ogbi S, Ergul A, Webb RC. Reduced Vascular Responses to Soluble Guanylyl Cyclase but Increased Sensitivity to Sildenafil in Female Rats with Type 2 Diabetes.   Am J Physiol Heart Circ Physiol. 2015 Jul 15;309(2):H297-304. doi: 10.1152/ajpheart.00079.2015. Epub 2015 May 8. IF:3.8

[2015] Hardigan T, Spitler K, Matsumoto T, Carrillo-Sepulveda MA. Activation of Toll-like receptor 3 increases mouse aortic vascular smooth muscle cell contractility through ERK1/2 pathway.   Pflugers Arch. 2015 Nov;467(11):2375-2385. Epub 2015 Mar 1. IF: 4.1

[2015] Matsumoto T, Watanabe S, Yamada K, Ando M, Iguchi M, Taguchi K, Kobayashi T. Relaxation Induced by Atrial Natriuretic Peptide Is Impaired in Carotid but Not Renal Arteries from Spontaneously Hypertensive Rats Due to Reduced BKCa Channel Activity.   Biol Pharm Bull. 2015;38(11):1801-8. doi: 10.1248/bpb.b15-00527. IF: 1.8

[2015] Carrillo-Sepulveda MA, Spitler K, Pandey D, Berkowitz DE, Matsumoto T. Inhibition of TLR4 attenuates vascular dysfunction and oxidative stress in diabetic rats.   J Mol Med (Berl). 2015 Dec;93(12):1341-54. doi: 10.1007/s00109-015-1318-7. Epub 2015 Jul 17. IF: 5.1

[2015] Taguchi K, Hida M, Matsumoto T, Kobayashi T. Resveratrol Ameliorates Clonidine-Induced Endothelium-Dependent Relaxation Involving Akt and Endothelial Nitric Oxide Synthase Regulation in Type 2 Diabetic Mice.   Biol Pharm Bull. 2015;38(12):1864-72. doi: 10.1248/bpb.b15-00403. IF: 1.8

[2014] Ishida K, Taguchi K, Matsumoto T, Kobayashi T. Activated Platelets from Diabetic Rats Cause Endothelial Dysfunction by Decreasing Akt/Endothelial NO Synthase Signaling Pathway.  PLoS One. 2014 Jul 21;9(7):e102310. doi: 10.1371/journal.pone.0102310. IF:3.5

[2014] Matsumoto T, Watanabe S, Taguchi K, Kobayashi T. Mechanisms underlying increased serotonin-induced contraction in carotid arteries from chronic type 2 diabetic Goto-Kakizaki rats.  Pharmacol Res. 2014 Jul 15;87C:123-132. doi: 10.1016/j.phrs.2014.07.001. IF:4.0

[2014] Taguchi K, Hida M, Matsumoto T, Ikeuchi-Takahashi Y, Onishi H, Kobayashi T. Effect of short-term polyphenol treatment on endothelial dysfunction and thromboxane A2 levels in streptozotocin-induced diabetic mice.    Biol Pharm Bull. 2014;37(6):1056-61. IF:1.8

[2014] Taguchi K, Sakata K, Ohashi W, Imaizumi T, Imura J, Hattori Y. Tonic inhibition by G protein-coupled receptor kinase 2 of Akt/endothelial nitric-oxide synthase signaling in human vascular endothelial cells under conditions of hyperglycemia with high insulin levels.       J Pharmacol Exp Ther. 2014 May;349(2):199-208. IF:3.9

[2014] Takebe M, Oishi H, Taguchi K, Aoki Y, Takashina M, Tomita K, Yokoo H, Takano Y, Yamazaki M, Hattori Y. Inhibition of Histone deacetylases protects septic mice from lung and splenic apoptosis.       J Surg Res. 2014 Apr;187(2):559-570. IF:2.1

[2014] Nemoto S, Matsumoto T, Taguchi K, Kobayashi T. Relationships among protein tyrosine phosphatase 1B, angiotensin II, and insulin-mediated aortic responses in type 2 diabetic Goto-Kakizaki rats.  Atherosclerosis. 2014 Mar;233(1):64-71. IF:4.0

[2014] Matsumoto T, Watanabe S, Kawamura R, Taguchi K, Kobayashi T. Enhanced uridine adenosine tetraphosphate-induced contraction in renal artery from type 2 diabetic Goto-Kakizaki rats due to activated cyclooxygenase/thromboxane receptor axis.         Pflugers Arch. 2014 Feb;466(2):331-42. IF:3.1

[2014] Hayashi T, Yamaguchi T, Sakakibara Y, Taguchi K, Maeda M, Kuzuya M, Hattori Y. eNOS-dependent antisenscence effect of a calcium channel blocker in human endothelial cells.     PLoS One. 2014 Feb 10;9(2):e88391. IF:3.5

[2014] Goulopoulou S, Hannan JL, Matsumoto T, Ergul A, Webb RC. Augmented dilation to nitric oxide in uterine arteries from rats with type 2 diabetes: implications for vascular adaptations to pregnancy.      Am J Physiol Heart Circ Physiol. 2014 Feb;306(4):H610-8. IF:4.0.

[2014] Hayashi T, Kotani H, Yamaguchi T, Taguchi K, Iida M, Ina K, Maeda M, Kuzuya M, Hattori Y, Ignarro LJ. Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes.     Proc Natl Acad Sci USA. 2014 Jan 21;111(3):1168-1173. IF:9.8

[2014] Carrillo-Sepulveda MA, Matsumoto T. Phenotypic Modulation of Mesenteric Vascular Smooth Muscle Cells from Type 2 Diabetic Rats is Associated with Decreased Caveolin-1 Expression. Cell Physiol Biochem. 2014;34(5):1497-506. doi: 10.1159/000366354. Epub 2014Oct 9. IF:3.6

[2013] Matsumoto T, Watanabe S, Kawamura R, Taguchi K, Kobayashi T. Epigallocatechin gallate attenuates ET-1-induced contraction in carotid artery from type 2diabetic OLETF rat at chronic stage of disease.   Life Sci. 2013 Dec 1.pii:S0024-3205 (13) 00738-8. doi:10.1016 /j.lfs.2013.11.016. IF:2.3

[2013] Tagashira H, Matsumoto T, Taguchi K, Zhang C, Han F, Ishida K, Nemoto S,Kobayashi T, Fukunaga K. Vascular Endothelial σ(1)-Receptor Stimulation With SA4503 Rescues Aortic Relaxation via Akt/eNOS Signaling in Ovariectomized Rats With Aortic Banding.  Circ J. 2013 Nov;77(11):2831-40.IF:3.7

[2013] Taguchi K, Matsumoto T, Kamata K, Kobayashi T. Suppressed G-protein-coupled receptor kinase 2 activity protects female diabetic-mouse aorta against endothelial dysfunction.     Acta Physiol (Oxf). 2013 Jan;207(1):142-55. IF:4.3

[2013] Spitler KM, Matsumoto T, Webb RC. Suppression of endoplasmic reticulum stress improves endothelium-dependent contractile responses in aorta of the spontaneously hypertensive rat.       Am J Physiol Heart Circ Physiol. 2013 Aug;305(3):H344-53. IF:4.0

[2013] Ishida K, Matsumoto T, Taguchi K, Kamata K, Kobayashi T. Mechanisms underlying reduced P2Y(1) -receptor-mediated relaxation in superior mesenteric arteries from long-term streptozotocin-induced diabetic rats. Acta Physiol (Oxf). 2013 Jan;207(1):130-41. IF: 4.3

[2012] Nemoto S, Taguchi K, Matsumoto T, Kamata K, Kobayashi T. Pravastatin normalizes ET-1-induced contraction in aorta of type 2 diabetic OLETF rat by suppressing kinase suppressor of Ras (KSR)-1/ERK complex.  Am J Physiol Heart Circ Physiol. 2012 Oct;303(7):H893-902. IF:4.0

[2012] Taguchi K, Morishige A, Matsumoto T, Kamata K, Kobayashi T. Enhanced estradiol-induced vasorelaxation in aortas from type 2 diabetic mice may reflect a compensatory role of p38 MAPK-mediated eNOS activation.  Pflugers Arch. 2012 Aug;464(2):205-15. IF:3.1

[2012] Kobayashi T, Nemoto S, Ishida K, Taguchi K, Matsumoto T, Kamata K. Involvement of CaM kinase II in the impairment of endothelial function and eNOS activity in aortas of Type 2 diabetic rats1.  Clin Sci (Lond). 2012 Sep 1;123(6):375-86. IF:5.6

[2012] Taguchi K, Matsumoto T, Kamata K, Kobayashi T. Inhibitor of G Protein-Coupled Receptor Kinase 2 Normalizes Vascular Endothelial Function in Type 2 Diabetic Mice by Improving β-Arrestin 2 Translocation and Ameliorating Akt/eNOS Signal Dysfunction. Endocrinology. 2012 Jul;153(7):2985-96.IF:4.6

[2012] Taguchi K, Matsumoto T, Kamata K, Kobayashi T. G Protein-Coupled Receptor Kinase 2, With β-Arrestin 2, Impairs Insulin-Induced Akt/Endothelial Nitric Oxide Synthase Signaling in ob/ob Mouse Aorta.  Diabetes. 2012 Aug;61(8):1978-85. IF:8.5

[2012] Nemoto S, Taguchi K, Matsumoto T, Kamata K and Kobayashi T. Aminoguanidine normalizes ET-1-induced aortic contraction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats by suppressing Jab1-mediated increase in ETA-receptor expression.        Peptides. 2012 Jan;33(1):109-19. IF:2.6

[2012] Taguchi K, Matsumoto T, Kamata K, Kobayashi T. Angiotensin II type 2 receptor-dependent increase in nitric oxide synthase activity in the endothelium of db/db mice is mediated via a MEK pathway.  Pharmacol Res. 2012 Jul;66(1):41-50. IF:4.0

[2012] Ishida K, Matsumoto T, Taguchi K, Kamata K, Kobayashi T. Protein kinase C delta contributes to increase in EP3 agonist-induced contraction in mesenteric arteries from type 2 diabetic Goto-Kakizaki rats.  Pflugers Arch. 2012 Apr;463(4):593-602. IF:3.1

[2012] Ishida K, Matsumoto T, Taguchi K, Kamata K, Kobayashi T. 　Pravastatin normalizes EDCF-mediated response via suppression of Rho-kinase signalling in mesenteric artery from aged type 2 diabetic rat.  Acta Physiol (Oxf). 2012 Jun;205(2):255-65. IF:4.3

[2012] Taguchi K, Matsumoto T, Kamata K, Kobayashi T. Akt/eNOS pathway activation in endothelium-dependent relaxation is preserved in aortas from female, but not from male, type 2 diabetic mice.   Pharmacol Res. 2012 Jan;65(1):56-65. IF:4.0

[2012] Matsumoto T, Tostes RC, Webb RC. Alterations in vasoconstrictor responses to the endothelium-derived contracting factor uridine adenosine tetraphosphate are region specific in DOCA-salt hypertensive rats.  Pharmacol Res. 2012 Jan;65(1):81-90. IF:4.0

[2012] Matsumoto T, Szasz T, Tostes RC, Webb RC. Impaired β-adrenoceptor-induced relaxation in small mesenteric arteries from DOCA-salt hypertensive rats is due to reduced K(Ca) channel activity.       Pharmacol Res. 2012 May;65(5):537-45. IF:4.0

[2012] Goulopoulou S, Matsumoto T, Bomfim GF, Webb RC. Toll-like receptor 9 activation: a novel mechanism linking placenta-derived mitochondrial DNA and vascular dysfunction in pre-eclampsia.     Clin Sci (Lond). 2012 Oct 1;123(7):429-35. IF:5.6

[2011] Nemoto S, Kobayashi T, Taguchi K, Matsumoto T, Kamata K. Losartan improves aortic endothelium-dependent relaxation via proline-rich tyrosine kinase 2/Src/Akt pathway in type 2 diabetic Goto-Kakizaki rats.  Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2383-94. IF:4.0

[2011] Ishida K, Matsumoto T, Taguchi K, Kamata K, Kobayashi T. Mechanisms underlying altered extracellular nucleotide-induced contractions in mesenteric arteries from rats in later-stage type 2 diabetes: effect of ANG II type 1 receptor antagonism.  Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1850-61. IF:4.0

[2011] Taguchi K, Kobayashi T, Takenouchi Y, Matsumoto T, Kamata K. Angiotensin II causes endothelial dysfunction via the GRK2/Akt/eNOS pathway in aortas from a murine type 2 diabetic model.  Pharmacol Res. 2011 Nov;64(5):535-46. IF:4.0

[2011] Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O,Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T.  Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.   Cell Metab. 2011 Mar 2;13(3):294-307. IF:16.7

[2011] Taguchi K, Kobayashi T, Matsumoto T, Kamata K. Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice.     Am J Physiol Heart Circ Physiol. 2011Aug;301(2):H571-83. IF:4.0

[2011] Matsumoto T, Tostes RC, Webb RC. Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from deoxycorticosterone acetate-salt hypertensive rats.     Am. J. Physiol. Heart Circ. Physiol. 2011 Aug;301(2):H409-H417. IF:4.0

2010年以前の業績につきましては、現スタッフの機能形態学研究室における論文のみ掲載します。

[2010 〜 1996]

Takenouchi Y, Kobayashi T, Taguchi K, Matsumoto T, Kamata K. Gender differences in vascular reactivity of aortas from streptozotocin-induced diabetic mice. Biol Pharm Bull. 2010;33(10):1692-7.

Sasaki Y, Suzuki M, Matsumoto T, Hosokawa T, Kobayashi T, Kamata K, Nagumo S. Vasorelaxant activity of Sappan Lignum constituents and extracts on rat aorta and mesenteric artery. Biol Pharm Bull. 2010;33(9):1555-60.

Matsumoto T, Kobayashi T, Ishida K, Taguchi K, Kamata K. Enhancement of mesenteric artery contraction to 5-HT depends on Rho kinase and Src kinase pathways in the ob/ob mouse model of type 2 diabetes. Br J Pharmacol. 2010 Jul;160(5):1092-104.

Matsumoto T, Kobayashi T (co-first), Ishida K, Hirasawa Y, Morita H, Honda T, Kamata K. Vasodilator effect of Cassiarin A, a novel antiplasmodial alkaloid from Cassia siamea, in rat isolated mesenteric artery. Biol Pharm Bull. 2010;33(5):844-8.

Takenouchi Y, Kobayashi T, Taguchi K, Matsumoto T, Kamata K. Relationship among superoxide-related enzyme, PPARs, and endothelium-dependent relaxation in murine aortas previously organ-cultured in high-glucose conditions. Can J Physiol Pharmacol. 2010 Jul;88(7):760-9.

Matsumoto T, Ishida K, Nakayama N, Taguchi K, Kobayashi T, Kamata K. Mechanisms underlying the losartan treatment-induced improvement in the endothelial dysfunction seen in mesenteric arteries from type 2 diabetic rats. Pharmacol Res. 2010 Sep;62(3):271-81..

Matsumoto T, Ishida K, Taguchi K, Kobayashi T, Kamata K. Losartan Normalizes Endothelium-Derived Hyperpolarizing Factor-Mediated Relaxation by Activating Ca(2+)-Activated K(+) Channels in Mesenteric Artery From Type 2 Diabetic GK Rat. J Pharmacol Sci. 2010 Mar 19;112(3):299-309.

Matsumoto T, Ishida K, Taguchi K, Kobayashi T, Kamata K. Short-term angiotensin-1 receptor antagonism in type 2 diabetic Goto-Kakizaki rats normalizes endothelin-1-induced mesenteric artery contraction. Peptides. 2010 Apr;31(4):609-17.

Matsumoto T, Ozawa Y, Taguchi K, Kobayashi T, Kamata K. Diabetes-associated changes and role of N(varepsilon)-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction. Peptides. 2010 Feb;31(2):346-53.

Matsumoto T, Ozawa Y, Taguchi K, Kobayashi T, Kamata K. Chronic treatment with losartan (angiotensin II type 1 receptor antagonist) normalizes enhanced acetylcholine-induced coronary vasoconstriction in isolated perfused hearts of type 2 diabetic OLETF rats. J Smooth Muscle Res. 2009 Oct;45(5):197-208

Takenouchi Y, Kobayashi T, Taguchi K, Matsumoto T, Kamata K. Gender Differences in Endothelial Function in Aortas From Type 2 Diabetic Model Mice. J Pharmacol Sci. 2009 Sep;111(1):91-9.

Kobayashi T, Taguchi K, Nemoto S, Nogami T, Matsumoto T, Kamata K. Activation of the PDK1/Akt /eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats. Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1767-75.

Matsumoto T, Ishida K, Taguchi K, Kobayashi T, Kamata K. Mechanisms underlying enhanced vasorelaxant response to protease-activated receptor 2-activating peptide in type 2 diabetic Goto-Kakizaki rat mesenteric artery. Peptides. 2009  Sep;30(9):1729-34..

Kamata K, Ozawa Y, Kobayashi T, Matsumoto T. Effect of N-epsilon-(carboxymethyl)lysine on coronary vasoconstriction in isolated perfused hearts from control and streptozotocin-induced diabetic rats. J Smooth Muscle Res. 2009 Jun;45(2-3):125-37.

Matsumoto T, Ishida K, Kobayashi T, Kamata K. Pyrrolidine dithiocarbamate reduces vascular prostanoid-induced responses in aged type 2 diabetic rat model. J Pharmacol Sci. 2009 Jul;110(3):326-33.

Takenouchi Y, Kobayashi T, Matsumoto T, Kamata K. Gender differences in age-related endothelial function in the murine aorta. Atherosclerosis. 2009 Oct;206(2):397-404.

Matsumoto T, Ishida K, Nakayama N, Kobayashi T, Kamata K. Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat. Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1388-97.

Matsumoto T, Nakayama N, Ishida K, Kobayashi T, Kamata K. Eicosapentaenoic acid improves imbalance between vasodilator and vasoconstrictor actions of endothelium-derived factors in mesenteric arteries from rats at chronic stage of type 2 diabetes.  J Pharmacol Exp Ther. 2009 Apr;329(1):324-34.

Matsumoto T, Takaoka E, Ishida K, Nakayama N, Noguchi E, Kobayashi T, Kamata K. Abnormalities of endothelium-dependent responses in mesenteric arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats are improved by chronic treatment with thromboxane A(2) synthase inhibitor. Atherosclerosis. 2009 Jul;205(1):87-95.

Kamata K, Ozawa Y, Kobayashi T, Matsumoto T. Effect of long-term streptozotocin-induced diabetes on coronary vasoconstriction in isolated perfused rat heart. J Smooth Muscle Res. 2008 Oct;44(5):177-88.

Matsumoto T, Noguchi E, Ishida K, Nakayama N, Kobayashi T, Kamata K. Cilostazol improves endothelial dysfunction by increasing endothelium-derived hyperpolarizing factor response in mesenteric arteries from Type 2 diabetic rats. Eur J Pharmacol. 2008 Dec 3;599(1-3):102-9

Kobayashi T, Nogami T , Taguchi K, Matsumoto T and Kamata K. Diabetic state, and high plasma insulin and Ang II combine to augment ET-1-induced contraction via ETA-receptor and ERK.  Br J Pharmacol. 2008 Dec;155(7):974-83

Matsumoto T, Noguchi E, Ishida K, Kobayashi T, Yamada N, Kamata K. Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes. Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1165-H1176.

Matsumoto T, Kakami M, Kobayashi T, Kamata K. Gender differences in vascular reactivity to endothelin-1 (1-31) in mesenteric arteries from diabetic mice. Peptides. 2008 Aug;29(8):1338-46.

Takenouchi Y, Kobayashi T, Matsumoto T, Kamata K. Possible involvement of Akt activity in endothelial dysfunction in type 2 diabetic mice. J Pharmacol Sci. 2008 Apr;106(4):600-8.

Fukushima M, Hattori Y, Tsukada H, Koga K, Kajiwara E, Kawano K, Kobayashi T, Kamata K, Maitani Y. Adiponectin gene therapy of streptozotocin-induced diabetic mice using hydrodynamic injection. J Gene Med. 2007 Nov;9(11):976-85

Matsumoto T, Kakami M, Noguchi E, Kobayashi T, Kamata K. Imbalance between endothelium-derived relaxing and contracting factors in mesenteric arteries from aged OLETF rats, a model of type 2 diabetes. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1480-90.

Kobayashi T, Taguchi K, Takenouchi Y, Matsumoto T, Kamata K. Insulin-induced impairment via peroxynitrite production of endothelium-dependent relaxation and sarco/endoplasmic reticulum Ca2+-ATPase function in aortas from diabetic rats. Free Radic Biol Med. 2007 Aug 1;43(3):431-43.

Matsumoto T, Noguchi E, Kobayashi T, Kamata K. Mechanisms underlying the chronic pioglitazone treatment-induced improvement in the impaired endothelium-dependent relaxation seen in aortas from diabetic rats. Free Radic Biol Med. 2007 Apr 1;42(7):993-1007.

Taguchi K, Kobayashi T, Hayashi Y, Matsumoto T, Kamata K.  Enalapril improves impairment of SERCA-derived relaxation and enhancement of tyrosine nitration in diabetic rat aorta. Eur J Pharmacol. 2007 Feb 5;556(1-3):121-8.

Matsumoto T, Kobayashi T, Wachi H, Seyama Y, Kamata K.       Vascular NAD(P)H oxidase mediates endothelial dysfunction in basilar arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Atherosclerosis. 2007 May;192(1):15-24.

Kamata K, Hosokawa M, Matsumoto T, Kobayashi T.      Altered arachidonic acid-mediated responses in the perfused kidney of the streptozotocin-induced diabetic rat. J Smooth Muscle Res. 2006 Oct;42(5):171-87.

Kamata K, Hosokawa M, Matsumoto T, Kobayashi T. Acetylcholine-induced vasodilation in the perfused kidney of the streptozotocin-induced diabetic rat: role of prostacyclin. J Smooth Muscle Res. 2006 Oct;42(5):159-70.

Kamata K, Satoh T, Matsumoto T, Noguchi E, Taguchi K, Kobayashi T, Tanaka H, Shigenobu K.    Enhancement of methoxamine-induced contractile responses of rat ventricular muscle in streptozotocin-induced diabetes is associated with alpha(1A) adrenoceptor upregulation.  Acta Physiol (Oxf). 2006 Nov;188(3-4):173-83.

Matsumoto T, Kobayashi T, Kamata K.  Mechanisms underlying lysophosphatidylcholine-induced potentiation of vascular contractions in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat aorta. Br J Pharmacol. 2006 Dec;149(7):931-41.

Matsumoto T, Miyamori K, Kobayashi T, Kamata K. Apocynin normalizes hyperreactivity to phenylephrine in mesenteric arteries from cholesterol-fed mice by improving endothelium-derived hyperpolarizing factor response. Free Radic Biol Med. 2006 Oct 15;41(8):1289-303.

Kamata K, Makino A, Kanie N, Oda S, Matsumoto T, Kobayashi T, Kikuchi T, Nishimura M, Honda T.       Effects of anthocyanidin derivative (HK-008) on relaxation in rat perfused mesenterial bed. J Smooth Muscle Res. 2006 Jun;42(2-3):75-88.

Matsumoto T, Kobayashi T, Kamata K.  Mechanisms underlying the impaired EDHF-type relaxation response in mesenteric arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Eur J Pharmacol. 2006 May 24;538(1-3):132-40.

Matsumoto T, Miyamori K, Kobayashi T, Kamata K.      Specific impairment of endothelium-derived hyperpolarizing factor-type relaxation in mesenteric arteries from streptozotocin-induced diabetic mice. Vascul Pharmacol. 2006 Jun;44(6):450-60.

Kobayashi T, Hayashi Y, Taguchi K, Matsumoto T, Kamata K. Angiotensin II enhances contractile responses via PI3-kinase p110{delta} pathway in aortas from diabetic rats with systemic hyperinsulinemia.  Am J Physiol Heart Circ Physiol. 2006; 291(2):H846-53.

Kobayashi T, Oishi K, Hayashi Y, Matsumoto T, Kamata K.  Changes in aortic endothelial gene expressions and relaxation responses following chronic short-term insulin treatment in diabetic rats   Atherosclerosis., 2006 Mar;185(1):47-57.

Matsumoto T, Nishiyama M, Kobayashi T, Kasuya Y, Kamata K.   Effect of phorbol 12,13-dibutyrate on smooth muscle tone in rat stomach fundus.  J Smooth Muscle Res. 2005 Apr;41(2):107-116.

Matsumoto T, Kobayashi T, Wakabayashi K, Kamata K. Cilostazol improves endothelium-derived hyperpolarizing factor-type relaxation in mesenteric arteries from diabetic rats.  Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H1933-40.

Matsumoto T, Wakabayashi K, Kobayashi T, Kamata K. Functional changes in adenylyl cyclases and associated decreases in relaxation responses in mesenteric arteries from diabetic rats.  Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H2234-43.

Endo K, Matsumoto T, Kobayashi T, Kasuya Y, Kamata K. Diabetes-related changes in contractile responses of stomach fundus to endothelin-1 in streptozotocin-induced diabetic rats.  J Smooth Muscle Res. 2005 Feb;41(1):35-47.

Matsumoto T, Kobayashi T, Kikuchi T, Honda T, Kamata K.  Effects of dual-action genistein derivatives on relaxation in rat aorta.  J Smooth Muscle Res. 2005 Feb;41(1):23-33.

Kamata K., Kobayashi T., Matsumoto T., Kanie N., Oda S., Kaneda A., Sugiura M. Effects of Chronic Administration of Fruit Extract (Citrus unshiu MARC) on Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats.  Biol Pharm Bull. 2005, 28(2):267-270.

Kobayashi T, Matsumoto T, Kamata K.  IGF-1-induced enhancement of contractile response in organ-cultured aortae from diabetic rats is mediated by sustained thromboxane A2 release from endothelial cells. J Endocrinol, 2005 Aug;186(2):367-76.

Kobayashi T., Taguchi K., Yasuhiro T., Matsumoto T., Kamata K. Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model.  Hypertension. 2004, 44(6):956-962.

Matsumoto T., Yoshiyama S., Wakabayashi K., Kobayashi T., Kamata K.   Effect of chronic insulin on cromakalim-induced relaxation in established streptozotocin-diabetic rat basilar artery.  Eur J Pharmacol. 2004, 504(1-2):129-137.

Matsumoto T., Yoshiyama S., Wakabayashi K., Kobayashi T., Kamata K.   Effects of chronic insulin on endothelial dysfunction of basilar arteries from established streptozotocin-diabetic rats.  Eur J Pharmacol.  2004, 504(1-2):119-127.

Matsumoto T., Yoshiyama S., Kobayashi T., Kamata K.  Mechanisms underlying enhanced contractile response to endothelin-1 in diabetic rat basilar artery.  Peptides. 2004, 25(11):1985-1994.

Matsumoto T., Wakabayashi K., Kobayashi T., Kamata K.  Diabetes-related changes in cAMP-dependent protein kinase activity and decrease in relaxation response in rat mesenteric artery.  Am J Physiol Heart Circ Physiol., 2004, 287(3):H1064-1071.

Matsumoto T., Oda S, Kobayashi T., Kamata K.  Flow-Induced Endothelium-Dependent Vasoreactivity in Rat Mesenteric Arterial Bed.  J smooth muscle research., 2004, 40(1): 1-14.

Kobayashi T., Matsumoto T., Ooishi K., Kamata K. Differential expressions of α2D-adrenoceptor and eNOS in aortae from early and later stages of diabetes in Goto-Kakizaki rats.  Am J Physiol Heart Circ Physiol., 2004, 287: Ｈ135-143.

Matsumoto T., Sato A., Suenaga H., Kobayashi T., Kamata K.  Modulations of shear stress-induced contractile responses and agonist-induced vasodilation in hypercholesterolemic rats.  Atherosclerosis., 2004, 175: 31-38.

Matsumoto T., Wakabayashi K., Kobayashi T., Kamata K.  Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats.  Can J Physiol Pharmacol. 2004, 82(3):175-182.

Kamata K, Kanie N, Matsumoto T, Kobayashi T.  Endothelin-1-induced impairment of endothelium-dependent relaxation in aortae isolated from controls and diabetic rats.  J Cardiovasc Pharmacol. 2004, 44, S186-S190.

Kobayashi T., Kaneda K., Kamata K.  Possible involvement of IGF-1 receptor and IGF-binding protein in insulin-induced enhancement of noradrenaline response in diabetic rat aorta.  Br J Pharmacol. 2003,140: 285-294.

Kanie N., Matsumoto T., Kobayashi T., Kamata K.  Relationship between peroxisome proliferator-activated receptors α (PPARα and PPARγ) and endothelium-dependent relaxation in streptozotocin-induced diabetic rats.  Br J Pharmacol. 2003,140: 23-32.

Kubota T., Kubota N., Moroi M., Terauchi Y., Kobayashi T., Kamata K., Suzuki R., Tobe K., Namiki A., Aizawa S., Nagai R., Kadowaki T., Yamaguchi T.  Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury.  Circulation.,2003, 107: 3073-3080.

Matsumoto T., Kobayashi T., Kamata K.  Alterations in EDHF-type relaxation and phosphodiesterase activity in mesenteric arteries from diabetic rats.  Am J Physiol Heart Circ Physiol., 2003, 285: H283-291.

Kobayashi T., Kamata K.  Short-term insulin treatment and aortic expressions of IGF-1 receptor and VEGF mRNA in diabetic rats.  Am J Physiol Heart Circ Physiol., 2002, 283: H1761-1768.

Kobayashi T., Kamata K.  Modulation by hydrogen peroxide of noradrenaline-induced contraction in aorta from streptozotocin-induced diabetic rat.  Eur. J. Pharmacol.,2002, 441: 83-89.

Kobayashi T., Kamata K.  Effect of chronic insulin treatment on NO metabolism and endothelium-dependent relaxation in rats aortae from established STZ-induced diabetic rats.  Atherosclerosis., 2001, 155: 313-320.

Kobayashi T., Matsumoto T., Kamata K.  Mechanisms underlying the chronic pravastatin treatment-induced improvement in the impaired endothelium-dependent aortic relaxation seen in streptozotocin-induced diabetic rats.  Br. J. Pharmacol., 2000, 131: 231-238.

Kobayashi T., Kamata K.  Effect of insulin treatment on the smooth muscle contractility and endothelium-dependent relaxation in rat aortae from established STZ-induced diabetes.  Br. J. Pharmacol. 1999, 127: 835-842.

Kobayashi T., Kamata K.  Relationships among cholesterol, superoxide anion and endothelium-dependent relaxation in diabetic rats.   Eur. J. Pharmacol. 1999, 67: 213-222.

Kamata K., Kobayashi T.  Changes in superoxide dismutase mRNA expression by streptozotocin-induced diabetes.   Br. J. Pharmacol. 1996, 119: 583-589.

総説

[2014] McCarthy CG, Goulopoulou S, Wenceslau CF, Spitler K, Matsumoto T, Webb RC. Toll-like receptors and damage-associated molecular patterns: novel links between inflammation and hypertension. Am J Physiol Heart Circ Physiol. 2014 Jan;306(2):H184-96.

[2014] Matsumoto T, Lopes RA, Taguchi K, Kobayashi T, Tostes RC. Linking the beneficial effects of current therapeutic approaches in diabetes to the vascular endothelin system. Life Sci. 2014 Jan 11. pii: S0024-3205(14)00011-3. doi:10.1016/j.lfs.2013.12.216.

[2014] Carrillo-Sepulveda MA, Matsumoto T, Nunes KP, Webb RC. Therapeutic implications of peptide interactions with G-protein-coupled receptors in diabetic vasculopathy. Acta Physiol (Oxf). 2014 May;211(1):20-35. doi: 10.1111/apha.12281. Epub 2014 Apr 4.

[2013] Taguchi K, Hattori Y. Unlooked-for significance of cardiac versus vascular effects of endothelin-1 in the pathophusiology of pulmonary arterial hypertension. Circulation research. 2013 Jan 18;112(2):227-229.

[2012]Goulopoulou S, Matsumoto T, Bomfim GF, Webb RC. Toll-like receptor 9 activation: a novel mechanism linking placenta-derived mitochondrial DNA and vascular dysfunction in pre-eclampsia. Clin Sci (Lond). 2012 Oct 1;123(7):429-35.

[2011] Matsumoto T.Tostes RC, Webb RC. The Role of Uridine Adenosine Tetraphosphate in the Vascular System. Advances in Pharmacological Sciences. 2011 (2011), Article ID 435132.

[2010] Matsumoto T, Kobayashi T, Kamata K. Diabetic conditions act as matchmaker for monocytes and vascular smooth muscle cells.  Am J Physiol Heart Circ Physiol. 2010Mar;298(3):H731-3. Epub 2009 Dec 18.

[2008] Matsumoto T, Kobayashi T, Kamata K. Relationships among ET-1, PPARgamma, oxidative stress and endothelial dysfunction in diabetic animals.  J Smooth Muscle Res. 2008 Apr;44(2):41-5

[2008] Matsumoto T, Kobayashi T, Kamata K. A therapeutic target for microvascular complications in diabetes.  Nippon Yakurigaku Zasshi. 2008;131(2):78-84. No abstract available

[2008] Kobayashi T.  Possible involvement of insulin and oxidative stress in vascular dysfunction of diabetic mellitus.  Yakugaku Zasshi. 2008 Jul;128(7):1013-21

[2007] Matsumoto T, Kobayashi T, Kamata K. Role of lysophosphatidylcholine (LPC) in atherosclerosis.  Curr Med Chem. 2007;14(30):3209-20

[2006] Matsumoto T., Kobayashi T., Kamata K.  A therapeutic target for microvascular complications in diabetes: Endothelium-derived hyperpolarizing factor.  Current Cardiology Reviews, 2006, 2, 185-191.

[2005] Kobayashi T., Matsumoto T., Kamata K. The PI3-K/Akt pathway: roles related to alterations in vasomotor responses in diabetic models. J Smooth Muscle Res. 2005 Dec;41(6):283-302.

[2004] Kobayashi T., Matsumoto T., Kamata K.  Endothelial dysfunction in diabetic animal models.  J Smooth Muscle Res (Jpn. Sec). 2004; 8: J49-J63.

[2003] Matsumoto T., Kobayashi T., Kamata K.  Phosphodiesterases in the vascular system.  J Smooth Muscle Res. 2003 ;39(4):67-86.