Fujita, T.; Sato, K.; Suzuki, T.; Ikeuchi, K.; Tanino, K.
Two-step Transformation of Ketones to Carboxylic Acids Through a Ring-opening Reaction of Epoxynitriles with a Squarate Anion Chem. Lett. 2025, accepted.
Yoshitani, A.; Sasage, T.; Kato, R.; Suzuki, T.; Ikeuchi, K.; Tanino, K.
Remodeling of Tricyclic Carbon Frameworks with a Norbornene Scaffold Chem. Commun. 2025, 61, 16372-16375.
Kobayashi, M.; Ono, M.; Sasage, T.; Yamazaki, Y.; Suzuki, T.; Tanino, K.; Nakamura, S.; Kanoh, N.; Ikeuchi, K.
Synthesis of Cyclobuta[cd]pentalenes via an Intramolecular Double Michael Addition Reaction of 1,3-Cyclopentanedione Derivatives Org. Lett. 2025, 27, 9341-9346.
Yoshiki, M.; Koyama, S.; Kobayashi, H,; Mimura, S.; Ri, T.; Nishiyama, H.; Sasano, Y.; Iwabuchi, Y.; Fujimoto, J.; Kimishima, A.; Honsho, N,; Yokoe, H.; Ikeuchi, K.; Asami, Y.; Kanoh, N.
Design and Synthesis of a 3‑Arylenoyltetramic Acid Library Employing a Consecutive Three-Component Coupling J. Org. Chem. 2025, 90, 10338-10351.
Kage, M.; Yamakoshi, H.; Tabata, M.; Ohashi, E.; Noguchi, K.; Watanabe, T.; Uchida, M.; Takada, M.; Ikeuchi, K.; Nakamura, S.
Oxidative Generation of Isobenzofurans from Phthalans: Application to the Formal Synthesis of (±)-Morphine Chem. Sci. 2024, 15, 19070–19076.
Watanabe, Y.; Haneda, T.; Kimishima, A.; Kuwae, A.; Suga, T.; Suzuki, T.; Iwabuchi, Y.; Honsho, M.; Honma, S.; Iwatsuki, M.; Matsui, H.; Hanaki, H.; Kanoh, N.; Abe, A.; Asami, Y.; Ōmura, S.
PurA is the main target of aurodox, a type III secretion system inhibitor Proc. Natl. Acad. Sci., U.S.A. 2024, 121(17), e2322363121. (Press Release in Japanese.)
2023
Tateishi, Y.; Sato, R.; Komatsu, S.; Noguchi, M.; Nagasawa, S.; Sasano, Y.; Kanoh, K.; Iwabuchi, Y.
Asymmetric Total Synthesis of Cytotrienin A: Late-stage Installation of C11 Side Chain onto the Macrolactam Scaffold Angew. Chem. Int. Ed.2023, 62, e20230314
Segawa, R.; Takeda, H.; Yokoyama, T.; Ishida, M.; Miyata, C.; Saito, T.; Ishihara, R.; Nakagita, T.; Sasano, Y.; Kanoh, N.; Iwabuchi, Y.; Mizuguchi, M.; Hiratsuka, M.; Hirasawa, N.
A chalcone derivative suppresses TSLP induction in mice and human keratinocytes through binding to BET family proteins Biochem. Pharmacol. 2021, 194, 114819.
Tanaka, T.; Okuyama-Dobashi, K.; Motohashi, R.; Yokoe, H.; Takahashi, K.; Wiriyasermkul, P.; Kasai, H.; Yamashita, A.; Maekawa, S.; Enomoto, N.; Ryo, A.; Nagamori, S.; Tsubuki, M.; Moriishi, K.
Inhibitory Effect of a Novel Thiazolidinedione Derivative on Hepatitis B Virus Entry Antiviral Res. 2021, 194, 105165.
Kanoh, N.; Terajima, Y.; Tanaka, S.; Terashima, R.; Nishiyama, H.; Nagasawa, S.; Sasano, Y.; Iwabuchi, Y.; Nishimura, S.; Kakeya, H.
Toward the Creation of Induced Pluripotent Small (iPS) Molecules: Establishment of a Modular Synthetic Strategy to the Heronamide C-type Polyene Macrolactams and Their Conformational and Reactivity Analysis J. Org. Chem.2021, 86, 16231-16248; ChemRxiv 2021, DOI: 10.33774/chemrxiv-2021-947db.
Kanoh, N.; Terashima, R.; Nishiyama, H.; Terajima, Y.; Nagasawa, S.; Sasano, Y.; Iwabuchi, Y.; Saito, H.; Egoshi, S.; Dodo, K.; Sodeoka, M.; Pan, C.; Ikeuchi, Y.; Nishimura, S.; Kakeya, H.
Design, Synthesis and Antifungal Activity of 16,17-Dihydroheronamide C and ent-Heronamide C J. Org. Chem.2021, 86, 16249-16258; ChemRxiv 2021, DOI: 10.33774/chemrxiv-2021-278l6.
Okamura, T.; Koyamada, K.; Kanazawa, J.; Miyamoto, K.; Iwabuchi, Y.; Uchiyama, M.; Kanoh, N.
Synthetic access to gem-difluoropropargyl vinyl ethers and their application to propargyl Claisen rearrangement J. Org. Chem. 2021, 86, 1311-2036.(featured as the Supplementary Cover Picture.)
2020
Yokoe, H.; Mizumura, Y.; Sugiyama, K.; Yan, K.; Hashizume, Y.; Endo, Y.; Yoshida, S.; Kiriyama, A.; Tsubuki, M.; Kanoh, N.
Rapid access to dispirocyclic scaffolds enabled by diastereoselective intramolecular double functionalization of benzene rings Chem. Asian J. 2020, 15, 4271-4274. (featured in "Hot Topic: C-C Coupling"and as the Cover Picture).
Takahashi, K.; Arai, Y.; Ikegami-Kawai, M.; Honda, T.
The formal synthesis of (+)-15-deoxy-Δ12,14-prostaglandin J2 by utilizing SmI2-promoted intramolecular coupling of bromoalkynes and α,β-unsaturated esters Tetrahedron2020, 76, 131148-131157.
Okamura, T.; Fujiki, S.; Iwabuchi, Y.; Kanoh, N.
Gold(I)-catalyzed Nicholas reaction with aromatic molecules utilizing a bifunctional propargyl dicobalt hexacarbonyl complex Org. Biomol. Chem.2019, 17, 8522-8526. (featured as the front cover).
Okamura, T.; Egoshi, S.; Dodo, K.; Sodeoka, M.; Iwabuchi, Y.; Kanoh, N.
Highly chemoselective gem-difluoropropargylation of aliphatic alcohols Chem. Eur. J.2019, 25, 16002-16006.
Kanoh, N.; Kawamata-Asano, A.; Suzuki, K.; Takahashi, Y.; Miyazawa, T.; Nakamura, T.; Moriya, T.; Hirano, H.; Osada, H.; Iwabuchi, Y.; Takahashi, S.
An integrated screening system for the selection of exemplary substrates for natural and engineered cytochrome P450s Sci. Rep.2019, 9, 18023.
Kanoh, N.; Fujiki, S.; Okamura, T.; Iwabuchi, Y.
錯体化合物、炭素炭素三重結合を有する化合物の製造方法、当該方法の中間体の製造方法及びこれらの方法に用いるキット
特開2019-151586
Tougan, T.; Takahashi, K.; Ikegami-Kawai, M.; Horiuchi, M.; Mori, S.; Hosoi, M.; Horii, T.; Ihara, M.; Tsubuki, M.
In vitro and in vivo characterization of anti-malarial acylphenoxazine derivatives prepared from basic blue 3 Malaria J. 2019, 18, 237.
Ishikawa, K.; Takahashi, K.; Hosoi, S.; Takeda, H.; Yoshida, H.; Wakana, D.; Tsubuki, M.; Sato, F.; Tojo, M.; Hosoe, T.
Antimicrobial agent isolated from Coptidis rhizome extract incubated with Rhodococcus sp. strain BD7100 J. Antibiot.2019, 72, 71-78.
Imai, M., Yokoe, H., Tsubuki, M., Takahashi, N.
Growth inhibition of human breast and prostate cancer cells by cinnamic acid derivatives and their mechanism of action Biol. Pharm. Bull. 2019, 42, 1134–1139.
2018 以前（叶）
Sasano, Y.; Koyama, J.; Yoshikawa, K.; Kanoh, N.; Kwon, E.; Iwabuchi, Y.
Stereocontrolled construction of ABCD tetracyclic ring system with vicinal all-carbon quaternary stereogenic centers of calyciphylline A type alkaloids Org. Lett.2018, 20, 3053-3056.
Uesugi, S.; Sasano, Y.; Matsui, S.; Kanoh, N.; Iwabuchi, Y. "Concise, protecting-group-free synthesis of (+)-nemonapride via Eu(OTf)3-catalyzed aminolysis of 3,4-epoxy alcohol Chem. Pharm. Bull.2017, 65, 22-24.
Morisaki, K.; Sasano, Y.; Koseki, T.; Shibuta, T.; Kanoh, N.; Chiou, W. H.; Iwabuchi, Y.
Nazarov cyclization entry to chiral bicyclo[5.3.0]decanoid building blocks and its application to formal synthesis of (-)-englerin A Org Lett2017, 19, 5142-5145.
Miyanaga, A.; Takayanagi, R.; Furuya, T.; Kawamata, A.; Itagaki, T.; Iwabuchi, Y.; Kanoh, N.; Kudo, F.; Eguchi, T.
Substrate recognition by a dual-function P450 monooxygenase GfsF involved in FD-891 biosynthesis Chembiochem2017, 18, 2179-2187.
Kanoh, N.; Okamura, T.; Suzuki, T.; Iwabuchi, Y.
A mild two-step propargylation of aromatic bioactive small molecules Org. Biomol. Chem.2017, 15, 7190 - 7195.
Nishiyama, Y.; Ohmichi, T.; Kazami, S.; Iwasaki, H.; Mano, K.; Nagumo, Y.; Kudo, F.; Ichikawa, S.; Iwabuchi, Y.; Kanoh, N.; Eguchi, T.; Osada, H.; Usui, T.
Vicenistatin induces early endosome-derived vacuole formation in mammalian cells Biosci. Biotech. Biochem.2016, 80, 902-910.
Kohyama, A.; Kanoh, N.; Kwon, E.; Iwabuchi, Y.
An enantiocontrolled entry to the tricyclic polar segment of (+)-fusarisetin A Tetrahedron Lett.2016, 57, 517-519.
Kohyama, A.; Fukuda, M.; Sugiyama, S.; Yamakoshi, H.; Kanoh, N.; Ishioka, C.; Shibata, H.; Iwabuchi, Y.
Reversibility of the thia-Michael reaction of cytotoxic C-5-curcuminoid and structure-activity relationship of bis-thiol-adducts thereof Org. Biomol. Chem.2016, 14, 10683-10687.
Kobayashi, H.; Sasano, Y.; Kanoh, N.; Kwon, E.; Iwabuchi, Y.
Total synthesis of the proposed structure of turkiyenine Eur. J. Org. Chem.2016, 270-273.
Kanoh, N.; Mano, K.; Saigusa, D.; Usui, T.; Iwabuchi, Y.
Design and synthesis of the penta(acetoxymethyl) ester of dioctanoyl phosphatidylinositol-3,5-bisphosphate Bioorg. Med. Chem. Lett.2016, 26, 5770-5772.
Kanoh, N.; Itoh, S.; Fujita, K.; Sakanishi, K.; Sugiyama, R.; Terajima, Y.; Iwabuchi, Y.; Nishimura, S.; Kakeya, H.
Asymmetric total synthesis of heronamides A-C: Stereochemical confirmation and impact of long-range stereochemical communication on the biological activity Chem. Eur. J.2016, 22, 8586-8595.
Kanoh, N.
Photo-cross-linked small-molecule affinity matrix as a tool for target identification of bioactive small molecules Nat. Prod. Rep.2016, 33, 709-718.
Itagaki, T.; Kawamata, A.; Takeuchi, M.; Hamada, K.; Iwabuchi, Y.; Eguchi, T.; Kudo, F.; Usui, T.; Kanoh, N.
Synthesis and structure-activity relationship study of FD-891: Importance of the side chain and C8-C9 epoxide for cytotoxic activity against cancer cells J. Antibiot.2016, 69, 287-293.
Uesugi, S.; Watanabe, T.; Imaizumi, T.; Ota, Y.; Yoshida, K.; Ebisu, H.; Chinen, T.; Nagumo, Y.; Shibuya, M.; Kanoh, N.; Usui, T.; Iwabuchi, Y.
Total synthesis and biological evaluation of irciniastatin A (a.k.a. psymberin) and irciniastatin B J. Org. Chem.2015, 80, 12333-12350.
Suzuki, T.; Okamura, T.; Tomohiro, T.; Iwabuchi, Y.; Kanoh, N.
Third generation photo-cross-linked small-molecule affinity matrix: A photoactivatable and photocleavable system enabling quantitative analysis of the photo-cross-linked small molecules and their target purification Bioconjugate Chem.2015, 26, 389-395.
Kanoh, N.
化合物の標的タンパク質を検出するための技術 生体の科学第66巻2号 特集「細胞を化学で観察する・操作する―発展著しい日本のケミカルバイオロジーを俯瞰する―」; 公益財団法人金原一郎記念医学医療新興財団／医学書院: 2015; Vol. 66, p 156-162.
Kanoh, N.
２章 標的同定の迅速化を目指した生物活性リガンドの非古典的修飾・固相担持法 CSJ カレントレビュー第19号「生物活性分子の標的同定と機能解明ー生命科学の基盤技術としてのアプローチ」; 化学同人: 2015; Vol. 19, p 48-56.
Hirano, S.; Quach, H. T.; Watanabe, T.; Kanoh, N.; Iwabuchi, Y.; Usui, T.; Kataoka, T.
Irciniastatin A, a pederin-type translation inhibitor, promotes ectodomain shedding of cell-surface tumor necrosis factor receptor 1 J. Antibiot.2015, 68, 417-420.
Hirano, S.; Quach, H. T.; Watahabe, T.; Kanoh, N.; Iwabuchi, Y.; Usui, T.; Kataoka, T.
Irciniastatin A induces a potent and sustained activation of extracellular signal-regulated kinase and thereby promotes ectodomain shedding of TNF receptor 1 in human lung carcinoma A549 cells Biol. Pharm. Bull.2015, 38, 941-946.
Uesugi, S.; Watanabe, T.; Imaizumi, T.; Shibuya, M.; Kanoh, N.; Iwabuchi, Y. "Eu(OTf)3-catalyzed highly regioselective nucleophilic ring opening of 2,3-epoxy alcohols: An efficient entry to 3-substituted 1,2-diol derivatives Org. Lett.2014, 16, 4408-4411.
Takahashi, S.; Nagano, S.; Nogawa, T.; Kanoh, N.; Uramoto, M.; Kawatani, M.; Shimizu, T.; Miyazawa, T.; Shiro, Y.; Osada, H.
Structure-function analyses of cytochrome P450revI involved in reveromycin A biosynthesis and evaluation of the biological activity of its substrate, reveromycin T J. Biol. Chem.2014, 289, 32446-32458.
Shibuta, T.; Sato, S.; Shibuya, M.; Kanoh, N.; Taniguchi, T.; Monde, K.; Iwabuchi, Y.
Enantioselective intramolecular aza-spiroannulation onto benzofurans using chiral rhodium catalysis Heterocycles2014, 89, 631-639.
Sakanishi, K.; Itoh, S.; Sugiyama, R.; Nishimura, S.; Kakeya, H.; Iwabuchi, Y.; Kanoh, N.
Total synthesis of the proposed structure of heronamide C Eur. J. Org. Chem.2014, 2014, 1376-1380.
Kanoh, N.; Kawamata, A.; Itagaki, T.; Miyazaki, Y.; Yahata, K.; Kwon, E.; Iwabuchi, Y.
A concise and unified strategy for synthesis of the C1-C18 macrolactone fragments of FD-891, FD-892 and their analogues: Formal total synthesis of FD-891 Org. Lett.2014, 16, 5216-5219.
Moriya, T.; Kawamata, A.; Takahashi, Y.; Iwabuchi, Y.; Kanoh, N
An improved fluorogenic NAD(P)+ detection method using 2-acetylbenzofuran: its origin and application Chem. Commun.2013, 49, 11500-11502.
Kanoh, N.; Suzuki, T.; Kawatani, M.; Katou, Y.; Osada, H.; Iwabuchi, Y.
Dual structure-activity relationship of osteoclastogenesis inhibitor methyl gerfelin based on TEG scanning Bioconjugate Chem.2013, 24, 44-52.
Kanoh, N.; Ohno, Y.; Itagaki, T.; Fukuda, H.; Iwabuchi, Y.
On the origin of cine-substitution in the Stille coupling of trisubstituted iodoalkene and trans-vinylstannane Synlett2013, 24, 2660-2664.
Fukuda, H.; Nishiyama, Y.; Nakamura, S.; Ohno, Y.; Eguchi, T.; Iwabuchi, Y.; Usui, T.; Kanoh, N.
Synthesis and structure-activity relationship of vicenistatin, a cytotoxic 20-membered macrolactam glycoside Chem. Asian J.2012, 7, 2872-2881.
Takayama, H.; Takahashi, S.; Moriya, T.; Osada, H.; Iwabuchi, Y.; Kanoh, N.
Detection of cytochrome P450 substrates by using a small-molecule droplet array on an NADH-immobilized solid surface ChemBioChem2011, 12, 2748-2752.
Takayama, H.; Moriya, T.; Kanoh, N.
Preparation of photo-cross-linked small molecule affinity matrices for affinity selection of protein targets for biologically active small molecules Chemical Genomics and Proteomics: Reviews and Protocols; Zanders, E. D., Ed.; Humana Press: Totowa, 2011, p 75-84.
Kawasumi, M.; Kanoh, N.; Iwabuchi, Y.
Concise entry to both enantiomers of 8-oxabicyclo[3.2.1]oct-3-en-2-one based on novel oxidative etherification: Formal synthesis of (+)-sundiversifolide Org. Lett.2011, 13, 3620-3623.
Kanoh, N.; Sakanishi, K.; Iimori, E.; Nishimura, K.; Iwabuchi, Y.
Asymmetric total synthesis of (–)-scabronine G via intramolecular double Michael reaction and Prins cyclization Org. Lett.2011, 13, 2864-2867.
Osada, H.; Kanoh, N.
Method of fixing low-molecular compound to solid-phase support
US Patent US 7713706 B2 (2010)
Yamakoshi, H.; Shibuya, M.; Tomizawa, M.; Osada, Y.; Kanoh, N.; Iwabuchi, Y.
Total synthesis and determination of the absolute configuration of (–)-idesolide Org. Lett.2010, 12, 980-983.
Yamakoshi, H.; Ohori, H.; Kudo, C.; Sato, A.; Kanoh, N.; Ishioka, C.; Shibata, H.; Iwabuchi, Y.
Structure-activity relationship of C5-curcuminoids and synthesis of their molecular probes thereof Bioorg. Med. Chem.2010, 18, 1083-1092.
Yamakoshi, H.; Kanoh, N.; Kudo, C.; Sato, A.; Ueda, K.; Muroi, M.; Kon, S.; Satake, M.; Ohori, H.; Ishioka, C.; Ohshima, Y.; Osada, H.; Chiba, N.; Shibata, H.; Iwabuchi, Y.
KSRP/FUBP2 is a binding protein of GO-Y086, a cytotoxic curcumin analogue ACS Med. Chem. Lett.2010, 1, 273-276.
Watanabe, T.; Imaizumi, T.; Chinen, T.; Nagumo, Y.; Shibuya, M.; Usui, T.; Kanoh, N.; Iwabuchi, Y.
Syntheses and biological evaluation of irciniastatin A and the C1-C2 alkyne analogue Org. Lett.2010, 12, 1040-1043.
Sato, Y.; Fukuda, H.; Tomizawa, M.; Masaki, T.; Shibuya, M.; Kanoh, N.; Iwabuchi, Y.
An enantio- and diastereocontrolled synthesis of (–)-salinosporamide A Heterocycles2010, 81, 2239-2246.
Kanoh, N.
光親和型小分子固定化を利用した小分子ー蛋白質間相互作用スクリーニングプラットフォーム 生命現象を理解する分子ツール 〜イメージングから生体機能解析まで〜; Hamachi, I., Futaki, S., Eds.; 化学同人: Kyoto, 2010, p 88-94.
Kanoh, N.
有機合成化学を基盤とした天然有機化合物のケミカルバイオロジー J. Syn. Org. Chem., Jpn.2010, 68, 939-950.
Kanoh, N.
第７章 各種バイオチップ 第４節 化合物チップ バイオチップ実用化ハンドブック; 金子周一, 堀池靖浩, 監修, Eds.; NTS Inc.: Tokyo, 2010, p 203-209.
Kanoh, N.
Construction of photo-cross-linked microarrays of small molecules Small Molecule Microarrays: Methods and Protocols; Yao, S. Q., Uttamchandani, M., Eds.; Humana Press: Totowa, 2010, p 17-22.
Fukuda, H.; Nakamura, S.; Eguchi, T.; Iwabuchi, Y.; Kanoh, N.
Concise total synthesis of vicenistatin Synlett2010, 2589-2592.
Chinen, T.; Nagumo, Y.; Watahabe, T.; Imaizumi, T.; Shibuya, M.; Kataoka, T.; Kanoh, N.; Iwabuchi, Y.; Usui, T.
Irciniastatin A/psymberin induces JNK activation which involves caspase-8-dependent apoptosis via mitochondria pathway Toxicol. lett.2010, 199, 341-346.
Yamakoshi, H.; Ikarashi, F.; Minami, M.; Shibuya, M.; Sugahara, T.; Kanoh, N.; Ohori, H.; Shibata, H.; Iwabuchi, Y.
Syntheses of naturally occurring cytotoxic [7.7]paracyclophanes, (–)-cylindrocyclophane A and its enantiomer, and implications for biological activity Org. Biomol. Chem.2009, 7, 3772-3781.
Sato, S.; Shibuya, M.; Kanoh, N.; Iwabuchi, Y. "Highly enantioselective intramolecular aza-spiroannulation onto indoles using chiral rhodium catalysis: asymmetric entry to the spiro-beta-lactam core of chartellines Chem. Commun.2009, 6264-6266.
Sato, S.; Shibuya, M.; Kanoh, N.; Iwabuchi, Y.
An expedient route to a potent gastrin/CCK-B receptor antagonist (+)-AG-041R J. Org. Chem.2009, 74, 7522-7524.
Miyazaki, I.; Okumura, H.; Simizu, S.; Takahashi, Y.; Kanoh, N.; Muraoka, Y.; Nonomura, Y.; Osada, H.
Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array Chembiochem2009, 10, 845-852.
Kanoh, N.; Osada, H.
Recent advances and developments of small molecule microarrays Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications; Osada, H., Ed.; Wiley: Hoboken, 2009, p 57-80.
Kanoh, N.
有機合成化学を基盤とした天然有機化合物のケミカルバイオロジー J. Syn. Org. Chem., Jpn.2009, 67, 272.
Ikeda, S.; Shibuya, M.; Kanoh, N.; Iwabuchi, Y.
Synthetic studies on daphnicyclidin A: Enantiocontrolled construction of the BCD ring system Org. Lett.2009, 11, 1833-1836.
Ichige, T.; Okano, Y.; Kanoh, N.; Nakata, M.
Total synthesis of methyl sarcophytoate, a marine natural biscembranoid J. Org. Chem.2009, 74, 230-243.
Shimizu, T.; Usui, T.; Fujikura, M.; Kawatani, M.; Satoh, T.; Machida, K.; Kanoh, N.; Woo, J. T.; Osada, H.; Sodeoka, M.
Synthesis and biological activities of reveromycin A and spirofungin A derivatives Bioorg. Med. Chem. Lett.2008, 18, 3756-3760.
Kawatani, M.; Okumura, H.; Honda, K.; Kanoh, N.; Muroi, M.; Dohmae, N.; Takami, M.; Kitagawa, M.; Futamura, Y.; Imoto, M.; Osada, H.
The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I Proc. Natl. Acad. Sci. U.S.A.2008, 105, 11691-11696.
Kanoh, N.; Nakamura, T.; Honda, K.; Yamakoshi, H.; Iwabuchi, Y.; Osada, H.
Distribution of photo-cross-linked products from 3-aryl-3-trifluoromethyldiazirines and alcohols Tetrahedron2008, 64, 5692-5698.
Ikeda, S.; Shibuya, M.; Kanoh, N.; Iwabuchi, Y.
Efficient entry to the pyrroloquinoline core of Martinella alkaloids via novel base-catalyzed Mukaiyama-Mannich reaction Chem. Lett.2008, 37, 962-963.
Simizu, S.; Miyazaki, I.; Kondoh, Y.; Kanoh, N.; Osada, H.
第10章 低分子アレイ マイクロアレイ・バイオチップの最新技術; Ito, Y., Ed.; CMC press: Tokyo, 2007, p 229-239.
Saito, A.; Kanoh, N.; Osada, H.
化合物アレイを用いた低分子-タンパク質相互作用の検出 実験医学別冊 分子間相互作用解析ハンドブック; 磯辺俊明、中山敬一、伊藤隆司, Ed.; Yodosha: Tokyo, 2007, p 225-229.
Kanoh, N.
Small-molecule microarray (in Japanese) ナノバイオ計測の実際; Mihara, K., Obata, E., Baba, Y., Eds.; Kodansya Scientific: Tokyo, 2007, p 52-62.
Ichige, T.; Okano, Y.; Kanoh, N.; Nakata, M.
Total synthesis of methyl sarcophytoate J. Am. Chem. Soc.2007, 129, 9862-9863.
Kanoh, N.; Osada, H.; Kyo, M.
相互作用観察法
特開2006-118920
Woo, J. T.; Kawatani, M.; Kato, M.; Shinki, T.; Yonezawa, T.; Kanoh, N.; Nakagawa, H.; Takami, M.; Lee, K. H.; Stern, P. H.; Nagai, K.; Osada, H.
Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts Proc. Natl. Acad. Sci. U.S.A.2006, 103, 4729-4734.
Kanoh, N.; Osada, H.
Small-molecule microarrays as tools for facilitating chemical genomics: Recent advances (in Japanese) J. Syn. Org. Chem. Jpn.2006, 64, 639-650.
Kanoh, N.; Kyo, M.; Inamori, K.; Ando, A.; Asami, A.; Nakao, A.; Osada, H.
SPR imaging of photo-cross-linked small-molecule arrays on gold Anal. Chem.2006, 78, 2226-2230.
Kanoh, N.; Asami, A.; Kawatani, M.; Honda, K.; Kumashiro, S.; Takayama, H.; Simizu, S.; Amemiya, T.; Kondoh, Y.; Hatakeyama, S.; Tsuganezawa, K.; Utata, R.; Tanaka, A.; Yokoyama, S.; Tashiro, H.; Osada, H.
Photo-cross-linked small-molecule microarrays as chemical genomic tools for dissecting protein-ligand interactions Chem. Asian J.2006, 1, 789-797.
Usui, T.; Kanoh, N.; Simizu, S.; Osada, H.
Bioprobes in forward and reverse chemical genetics (in Japanese) 実験医学2005, 23, 1802-1809.
Teruya, T.; Simizu, S.; Kanoh, N.; Osada, H.
Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells FEBS Lett.2005, 579, 2463-2468.
Osada, H.; Kanoh, N.
Small-molecule microarrays (in Japanese) バイオテクノロジージャーナル (Biotechnology Journal)2005, 5, 724-727.
Kanoh, N.; Simizu, S.; Usui, T.; Osada, H.
Forward and reverse chemical genetics utilizing naturally occurring bioprobes (in Japanese) 蛋白質核酸酵素 (Tanpakushitsu Kakusan Koso)2005, 50, 1037-42.
Kanoh, N.; Honda, K.; Simizu, S.; Muroi, M.; Osada, H.
Photo-cross-linked small-molecule affinity matrix for facilitating forward and reverse chemical genetics (vol. 44, p3559, 2005) Angew. Chem. Int. Ed.2005, 44, 4282-4282.
Kanoh, N.; Honda, K.; Simizu, S.; Muroi, M.; Osada, H.
Photo-cross-linked small-molecule affinity matrix for facilitating forward and reverse chemical genetics Angew. Chem. Int. Ed.2005, 44, 3559-3562.
Ichige, T.; Kamimura, S.; Mayumi, K.; Sakamoto, Y.; Terashita, S.; Ohteki, E.; Kanoh, N.; Nakata, M.
Synthetic studies on biscembranoids: Asymmetric total synthesis of methyl sarcoate Tetrahedron Lett.2005, 46, 1263-1267.
Kanoh, N.; Osada, H.
固相単体への低分子化合物の固定化法
特開2004-309372
Woo, J.; Kawatani, M.; Kato, M.; Yonezawa, H.; Kanoh, N.; Shinki, T.; Takami, M.; Osada, H.; Stern, P.; Nagai, K.
Reveromycin A, which induces apoptosis specifically in functional osteoclasts, inhibits bone resorption in vitro and in vivo J. Bone. Miner. Res.2004, 19, S417-S417.
Usui, T.; Watanabe, H.; Nakayama, H.; Tada, Y.; Kanoh, N.; Kondoh, M.; Asao, T.; Takio, K.; Watanabe, H.; Nishikawa, K.; Kitahara, T.; Osada, H.
The anticancer natural product pironetin selectively targets Lys352 of alpha-tubulin Chem. Biol.2004, 11, 799-806.
Ichige, T.; Miyake, A.; Kanoh, N.; Nakata, M.
Oxidative deprotection of 1,3-dithiane group using NaClO2 and NaH2PO4 in aqueous methanol Synlett2004, 1686-1690.
Terauchi, T.; Terauchi, T.; Sato, I.; Shoji, W.; Tsukada, T.; Tsunoda, T.; Kanoh, N.; Nakata, M.
Formal total synthesis of altohyrtin C (spongistatin 2). Part 1: Aldol approach to unite AB and CD spiroacetals Tetrahedron Lett.2003, 44, 7741-7745.
Terauchi, T.; Tanaka, T.; Terauchi, T.; Morita, M.; Kimijima, K.; Sato, I.; Shoji, W.; Nakamura, Y.; Tsukada, T.; Tsunoda, T.; Hayashi, G.; Kanoh, N.; Nakata, M.
Formal total synthesis of altohyrtin C (spongistatin 2). Part 2: Construction of fully elaborated ABCD and EF fragments Tetrahedron Lett.2003, 44, 7747-7751.
Smith, A. B., III; Kanoh, N.; Ishiyama, H.; Minakawa, N.; Rainier, J. D.; Hartz, R. A.; Cho, Y. S.; Cui, H.; Moser, W. H.
Tremorgenic indole alkaloids. The total synthesis of (–)-penitrem D J. Am. Chem. Soc.2003, 125, 8228-37.
Kanoh, N.; Tomatsu, A.; Nishikawa, T.; Ide, M.; Tsuchida, T.; Isshiki, K.; Nakata, M
Practical deracemization of NM-3, a synthetic angiogenesis inhibitor Tetrahedron-Asymm.2003, 14, 1251-1253.
Kanoh, N.; Kumashiro, S.; Simizu, S.; Kondoh, Y.; Hatakeyama, S.; Tashiro, H.; Osada, H.
Toward the construction of universal small-molecule microarrays: functional group independently-immobilized arrays of small molecules Biomolecular Chemistry: A Bridge for the Future; the scientific committee of ISBC 2003, Ed.; Maruzen: Tokyo, 2003, p 330-331.
Kanoh, N.; Kumashiro, S.; Simizu, S.; Kondoh, Y.; Hatakeyama, S.; Tashiro, H.; Osada, H.
Immobilization of natural products on glass slides by using a photoaffinity reaction and the detection of protein-small-molecule interactions Angew. Chem. Int. Ed.2003, 42, 5584-5587.
Fukuzaki, T.; Kobayashi, S.; Hibi, T.; Ikuma, Y.; Ishihara, J.; Kanoh, N.; Murai, A.
Studies aimed at the total synthesis of azadirachtin. A modeled connection of C-8 and C-14 in azadirachtin Org. Lett.2002, 4, 2877-2880.
Terauchi, T.; Morita, M.; Kimijima, K.; Nakamura, Y.; Hayashi, G.; Tanaka, T.; Kanoh, N.; Nakata, M.
Synthetic studies on altohyrtins (spongistatins): Synthesis of the C29-C44 (EF) portion Tetrahedron Lett.2001, 42, 5505-5508.
Yamamoto, Y.; Ishihara, J.; Kanoh, N.; Murai, A.
Synthetic studies on azadirachtin: An efficient asymmetric synthesis of the highly functionalized tricyclic decalin part of azadirachtin Synthesis2000, 1894-1906.
Terauchi, T.; Terauchi, T.; Sato, I.; Tsukada, T.; Kanoh, N.; Nakata, M.
Synthetic studies on altohyrtins (spongistatins): Synthesis of the C15-C28 (CD) spiroacetal portion Tetrahedron Lett.2000, 41, 2649-2653.
Smith, A. B., III; Kanoh, N.; Ishiyama, H.; Hartz, R. A.
Total synthesis of (–)-penitrem D J. Am. Chem. Soc.2000, 122, 11254-11255.
Kanoh, N.; Ishihara, J.; Yamamoto, Y.; Murai, A.
Synthetic studies on azadirachtin: Asymmetric synthesis of the tetracyclic decalin part of azadirachtin Synthesis2000, 1878-1893.
Smith, A. B., III; Kanoh, N.; Minakawa, N.; Rainier, J. D.; Blase, F. R.; Hartz, R. A.
remorgenic indole alkaloids. Studies directed toward the assembly of the A, F, and I rings of penitrem D: Observation of an unexpected stereochemical outcome Org. Lett.1999, 1, 1263-1266.
Ishihara, J.; Yamamoto, Y.; Kanoh, N.; Murai, A.
Synthetic studies on azadirachtin: Construction of the highly functionalized decalin moiety of azadirachtin Tetrahedron Lett.1999, 40, 4387-4390.
Kanoh, N.; Ishihara, J.; Murai, A.
Synthetic study on azadirachtin: Asymmetric synthesis of the tetracyclic decalin part of azadirachtin Synlett1997, 737-739.
Ishihara, J.; Shimada, Y.; Kanoh, N.; Takasugi, Y.; Fukuzawa, A.; Murai, A.
Conversion of prelaureatin into laurallene, a bromo-allene compound, by enzymatic and chemical bromo-etherification reactions Tetrahedron1997, 53, 8371-8382.
Kanoh, N.; Ishihara, J.; Murai, A.
Construction of the tricyclic trans-decalin framework of azadirachtins via intramolecular Diels-Alder reaction Synlett1995, 895-897.
Ishihara, J.; Kanoh, N.; Murai, A.
Enzymatic reaction of (3E,6S,7S)-laurediol and the molecular modeling studies on the cyclization of laurediols Tetrahedron Lett1995, 36, 737-740.
Ishihara, J.; Kanoh, N.; Fukuzawa, A.; Murai, A.
Isomerization of the (Z)-enyne unit to the (E)-enyne unit - Conversion of laureatin to (E)-isolaureatin Chem. Lett.1994, 1563-1564.
2024 赴任以前（池内）
Suzuki, T.; Yamashita, K.; Ikeda, W.; Ikeuchi, K; Tanino, K.
Novel Radical Cyclization Cascade for the Unified Synthesis of the Cedrane and Clovane Sesquiterpene Skeletons Asian J. Org. Chem.2024, 13, e202400242.
Ikeuchi, K.; Hirokawa, Y.; Sasage, T.; Fujii, R.; Yoshitani, A.; Suzuki, T.; Tanino, K.
Unique Reactivity of the 1,4-Bis(silyloxy)-1,3-cyclopentadiene Moiety: Application to the Synthesis of 7-Norbornanone Derivatives Chem. Eur. J.2024, 30, e202401908.
Ikeuchi, K.
Development of Methodologies toward the Unified Synthesis of Ellagitannins Chem. Pharm.Bull. 2024, 72, 349–359.
Sato, K.; Fujita, T.; Takeuchi, T.; Suzuki, T.; Ikeuchi, K.; Tanino, K.
Alcohol synthesis based on the SN2 reactions of alkyl halides with squarate dianion Org. Biomol. Chem.2024, 22,1369–1373.
Ikeuchi, K.; Haraguchi, S.; Fujii, R.; Yamada, H.; Suzuki, T.; Tanino, K.
Total Synthesis of (+)-Coriamyrtin involving a Desymmetrizing Strategy of a 1,3-Cyclopentanedione Moiety Org. Lett.2023,25, 2751–2755.
Ikeuchi, K.; Ozoe, Y.; Kato, R.; Suzuki, T.; Tanino, K.
Synthesis of 2-alkyl-2-(2-furanyl)-1,3-cyclopentanedione Synthesis2023, 55, 2751–2755.
Suzuki, T.; Ikeda, W.; Kanno, A.; Ikeuchi, K.; Tanino, K.
Diastereoselective Synthesis of trans-anti-Hydrophenanthrenes via Ti-mediated Radical Cyclization and Total Synthesis of Kamebanin Chem. Eur. J.2023, 29, e202203511
Kato, R.; Saito, H.; Ikeuchi, K.; Suzuki, T.; Tanino, K.
Total Synthesis and Structural Revision of the 6,11-Epoxyisodaucane Natural Sesquiterpene Using an Anionic 8π Electrocyclic Reaction Org. Lett.2022,24, 7939–7943.
Kato, K.; Ikeuchi, K.; Suzuki, T.; Tanino, K.
Total Synthesis of 2-Isocyanoallopupukeanane: Construction of Caged Skeleton by Intramolecular Alkylation of Bromonitriles Org. Lett. 2022,24,6407–6411.
Hashimoto, H.; Wakamori, S.; Ikeuchi, K.; Yamada, H.
Divergent Synthesis of Four Monomeric Ellagitannins toward the Total Synthesis of an Oligomeric Ellagitannin, Nobotanin K Organics 2022, 3, 293–303.
Ogura, R.; Satoh, K.; Kiuchi, W.; Kato, K.; Ikeuchi, K.; Suzuki, T.; Tanino, K.
Two-Step Method for Constructing a Quaternary Carbon Atom with a Geminal Divinyl Group from a Ketone Org. Lett. 2022, 24, 5040–5044.
Ikeuchi, K.; Haraguchi, S.; Yamada, H.; Tanino, K.
Model Synthetic Study of Tutin, a Picrotoxane-type Sesquiterepene: Stereoselective Construction of a cis-Fused 5,6-Ring Skeleton Chem. Pharm. Bull.2022, 70, 435–442.
Yukutake, Y.; Hiramatsu, T.; Itoh, R.; Ikeuchi, K.; Suzuki, T.; Tanino, K.
Synthetic Studies on Tubiferal A: Asymmetric Synthesis of ABC-ring Model Compound Synlett2022, 33, 296–300.
Kishi, J.; Ikeuchi, K.; Suzuki, T.; Tanino, K.
Synthetic Studies of Daphniphyllum Alkaloids: A New Method for the Construction of [7-5-5] All-carbon Tricyclic Skeleton Synlett2022, 33, 196–200.
Saito, H.; Kato, R.; Ikeuchi, K.; Suzuki, T.; Tanino, K.
8π Electrocyclic Reaction of Phosphonate Derivatives: Access to Seven-Membered Cross-Conjugated Cyclic Trienes Org. Lett.2021, 23, 9606–9610.
Ikeuchi, K.; Sasage, T.; Yamada, G.; Suzuki, T.; Tanino, K.
Synthesis of a Bicyclo[2.2.1]heptane Skeleton with Two Oxy-functionalized Bridgehead Carbons via the Diels–Alder Reaction Org. Lett. 2021, 23, 9123–9127.
Kato, R.; Saito, H.; Uda, S.; Domon, D.; Ikeuchi, K.; Suzuki, T.; Tanino, K.
Synthesis of Seven-Membered Cross-Conjugated Cyclic Trienes by 8π Electrocyclic Reaction Org. Lett.2021, 23, 8878–8882.
Suzuki, T.; Nagahama, R.; Fariz, M. A.; Yukutake, Y.; Ikeuchi, K.; Tanino, K.
Synthesis of Illisimonin A Skeleton by Intramolecular Diels–Alder Reaction of Ortho-Benzoquinones and Biomimetic Skeletal Rearrangement of Allo-Cedranes Organics2021, 2, 306–312.
Ikeuchi, K.; Matsumoto, S.; Ikuta, D.; Yamada, H.
Glycosylation by the Alkyne Activation of the 2-O-Substituted Propargyl Group in a β-Phenylthioglucoside with a 5S1 Conformation Synlett2021, 32, 817–821.
Bando, M.; Kawasaki, Y.; Nagata, O.; Okada, Y.; Ikuta, D.; Ikeuchi, K.; Yamada, H.
β-Selective glycosylation using axial-rich and 2-O-rhamnosylated glucosyl donors controlled by the protecting pattern of the second sugar Chem. Pharm. Bull. 2021, 69, 124–140.
Hashimoto, H.; Ishimoto, T.; Konishi, H.; Hirokane, T.; Wakamori, S.; Ikeuchi, K.; Yamada, H.
Synthesis of an Ellagitannin Component, the Macaranoyl Group with a tetra-ortho-Substituted Diaryl Ether Structure Org. Lett. 2020, 22,6729–6733.
Yamashita, K.; Kume, Y.; Ashibe, S.; Puspita, C. A. D.; Tanigawa, K.; Michihata, N.; Wakamori, S.; Ikeuchi, K.; Yamada, H.
Total Synthesis of Mallotusinin Chem. Eur. J. 2020, 26,16408–16421.
Ikeuchi, K.; Murasawa, K.; Arai, T.; Yamada, H. p-Methylbenzyl 2,2,2-trichloroacetimidate: Simple Preparation and Application to Alcohol Protection Chem. Lett. 2020, 49,1034–1037.
Wakamori, S.; Matsumoto, S.; Kusuki, R.; Ikeuchi, K.; Yamada, H.
Total Synthesis of Casuarinin Org. Lett. 2020, 22,3392–3396.
Konishi, H.; Hirokane, T.; Hashimoto, H.; Ikeuchi, K.; Matsumoto, S.; Wakamori, S.; Yamada, H.
Synthesis of Diaryl Ether Components of Ellagitannins Using Ortho-quinone with Consonant Mesomeric Effects Chem. Commun. 2020, 56, 3991–3994.
Ikeuchi, K.; Ueji, T.; Matsumoto, S.; Wakamori, S.; Yamada, H.
First Total Synthesis of Neostrictinin Eur. J. Org. Chem. 2020, 2077–2085.
Ikeuchi, K.; Murasawa, K.; Ohara, K.; Yamada, H. p-Methylbenzyl Group: Oxidative Removal and Orthogonal Alcohol Deprotection Org. Lett. 2019, 21, 6638–6642.
Takemura, H.; Choi, J.-H.; Matsuzaki, N.; Taniguchi, Y.; Wu, J.; Hirai, H.; Motohashi, R.; Asakawa, T.; Ikeuchi, K.; Inai, M.; Kan, T.; Kawagishi, H.
A Fairy Chemical, Imidazole-4-carboxamide, is Produced on a Novel Purine Metabolic Pathway in Rice Sci. Rep. 2019, 9:9899.
Ikeuchi, K.; Murasawa, K.; Yamada, H.
A Simple Method for the Preparation of Stainless and Highly Pure Trichloroacetimidates Synlett 2019, 30, 1308–1312.
Ouchi, H.; Asakawa, T.; Ikeuchi, K.; Inai, M.; Choi, J.-H.; Kawagishi, H.; Kan, T.
Synthesis of double-13C-labeled imidazole derivatives Tetrahedron Lett. 2018,59, 3516–3518.
Yamada, H.; Wakamori, S.; Hirokane, T.; Ikeuchi, K.; Matsumoto, S.
“Structural Revisions in Natural Ellagitannins” Molecules2018, 23, 1901.
Ashibe, S.; Ikeuchi, K.; Kume, Y.; Wakamori, S.; Ueno, Y.; Iwashita, T.; Yamada, H.
Non-enzymatic Oxidation of a Pentagalloylglucose Analog to Ellagitannins Angew. Chem. Int. Ed. 2017, 56, 15402–15406.
Kaneko, Y.; Wakamori, S.; Ikeuchi, K.; Ohara, K.; Tanaka, T.; Yamada, H.
Total Synthesis of Lagerstannin C: Follow-up of the Khanbabaee’s Synthesis Synthesis 2017, 49, 5003–5006.
Yamada, H.; Hirokane, T.; Ikeuchi, K.; Wakamori, S.
Fundamental methods in ellagitannin synthesis Nat. Prod. Commun.2017, 12, 1351–1358.
Hirokane, T.; Ikeuchi, K.; Yamada, H.
Total Syntheses of Laevigatin A and E Eur. J. Org. Chem. 2015,7352–7359.
Ikeuchi, K.; Fujii, R.; Sugiyama, S.; Asakawa, T.; Inai, M.; Hamashima, Y.; Choi, J.-H.; Suzuki, T.; Kawagishi, H.; Kan, T.
Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes Org. Biomol. Chem. 2014, 12, 3813–3815.
Hirooka, Y.; Ikeuchi, K.; Kawamoto, Y.; Akao, Y.; Furuta, T.; Asakawa, T.; Inai, M.; Wakimoto, T.; Fukuyama, T.; Kan, T.
Enantioselective Synthesis of SB-203207 Org. Lett. 2014, 16, 1646–1649.
Ikeuchi, K.; Hayashi, M.; Yamamoto, T.; Inai, M.; Asakawa, T.; Hamashima, Y.; Kan, T.
Stereocontrolled total synthesis of sphingofungin E Eur. J. Org. Chem. 2013,6789–6792.
Ikeuchi, K.; Ido, S.; Yoshimura, S.; Asakawa, T.; Inai, M.; Hamashima, Y.; Kan, T.
Catalytic Desymmetrization of Cyclohexadienes by Asymmetric Bromolactonization Org. Lett. 2012, 14, 6016–6019.
Sakai, Y.; Ikeuchi, K.; Yamada, Y.; Wakimoto, T.; Kan, T.
Modified Julia-Kocienski Reaction Promoted by Means of m-NPT (Nitrophenyltetrazole) sulfone Synlett 2010, 827–829.
The 29th French-Japanese Symposium on Medicinal and Fine Chemistry（Tohoku University, Sendai, 5月18-21日）
Theoretical Analysis of Structural and Electronic Characteristics of Naturally Occurring Multipotent Polyene Macrolactams（Poster Presentation）
〇Naoki Kanoh, Junko Fujimoto
Celebrating 50 Years of Excellence at PENN: A Symposium in Honor of Professor Amos B. Smith, III（Penn Museum, University of Pennsylvania, Philadelphia, 9月13日）
Group Meeting #10: From the Synthesis and Target ID of Complex Natural Products to the Design of Multipotent Polyene Macrolactams（Invited Short Presentation）
〇Naoki Kanoh
第114回北里大学 KMCF（Kitasato Microbial Chemistry Frontier）セミナー（北里大学・大村智記念研究所、11月20日）
Toward the creation of multipotent small or middle-sized organic molecules（依頼講演）
叶 直樹
28th French-Japanese Symposium on Medicinal & Fine Chemistry（Château de Valrose, Université Côte d'Azur, Nice, France, 10月3日）
Toward the creation of induced pluripotent small (iPS) molecules based on polyene macrolactam natural products（Poster presentation）
Naoki Kanoh
Univerisity of Rouen Normandy Conference（Univerisity of Rouen Normandy, Rouen, France, 9月29日）
Toward the creation of multipotent molecules based on polyene macrolactam natural products（Conference lecture）
Naoki Kanoh
The 6th Asian Chemical Biology Conference（ICC Jeju, Korea, 8月20-23日）
Toward the creation of induced pluripotent small (iPS) molecules inspired by naturally occurring polyene macrolactams（Oral presentation）
Naoki Kanoh
Future Drug Discovery Empowered by Chemical Biology（Nara Kasugano International Forum, Nara, Japan, 2月21-22日）
Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation（Poster presentation）
〇Yifan Huang, Hiromasa Yokoe, Ai Kaiho-Soma, Kazunori Takahashi, Yusuke Hirasawa, Hiroshi Morita, Hiroaki Saito, Fumiaki Ohtake, Naoki Kanoh
The International Chemical Congress of Pacific Basin Societies 2021［PACIFICHEM2021］, Chemical Communications through Natural and Synthetic Bioactive Compounds （オンライン開催、12月16-21日）
Dynamical structure and thermal stability of polyene macrolactam heronamides in lipid bilayer: A molecular dynamics study（Poster presentation）
〇Hiroaki Saito，Naoki Kanoh
ダブルスピロ環化反応を活用したグランジロジン C の全合成研究（口頭発表）
〇横江弘雅、津吹政可、叶 直樹
Julius-Maximilians-Universität Würzburg ─ Hoshi University Joint Mini Symposium（星薬科大学、2月28日）
Late-stage functionalization of small molecules using metal complexes（Invited lecture）
Naoki Kanoh
International Society of Heterocyclic Chemistry Congress（京都、9月1-6日）
Novel difluoropropargylation of alcohols and ketones with difluoropropargyl dicobalt complexes: Access to various cyclic alpha-Fluoroethers（Poster presentation）
○Toshitaka Okamura, Yoshiharu Iwabuchi, Naoki Kanoh
Second-generation synthesis and biological evaluation of heronamides, naturally occurring polyene macrolactams (Oral presentation)
○Naoki Kanoh, Ryusei Terashima, Suguru Tanaka, Yuta Terajima, Hiromichi Nishiyama, Yoshiharu Iwabuchi
2nd Soft Matter Activation Research Center Symposium: New Stream of Chemical Biology (Chiba Univ., July 25)
Late-stage functionalization of small molecules using metal complexes and enzymes (Invited lecture)
Naoki Kanoh
第30回仙台万有シンポジウム（仙台、6月29日）
ジフルオロプロパルギルブロミドを利用した新規 Nicholas 型分子変換反応の開発と応用（ポスター発表）
〇岡村俊孝、岩渕好治、叶 直樹
The 1st International Symposium on Chemical Communication (ISCC2019)（東京、1月9-10日）
Dynamical structure and thermal stability of polyene macrolactam heronamide C and A in lipid bilayer: a molecular dynamics study （Poster presentation）
〇Hiroaki Saito，Naoki Kanoh
Kawatani, I. M.; Honda, K.; Kanoh, N.; Muroi, M.; Dohmae, N.; Imoto, M.; Osada, H.
The identification of a novel inhibitor of osteoclastogenesis that acts via inhibition of glyoxalase I Mol. Cancer. Ther. 2007, 6, 3607S-3607S.
Haruta, K.; Tanaka, Y.; Kawamura, T.; Kondo, Y.; Ono, A.; Yamakoshi, H.; Kanoh, N.; Iwabuchi, Y.
Synthesis of an enantiomeric DNA oligomer and its T-Hg(II)-T base-pair formation Nucleic Acids Symp. Ser., 2007, 187-8.
Kawatani, M.; Kanoh, N.; Osada, H.
Selective action of reveromycin A, a novel anti-resorptive agent, on osteoclasts EJC Suppl. 2006, 4, 158-158.
Osada, H.; Mugurama, H.; Yano, S.; Kawatani, M.; Shinki, T.; Woo, J. T.; Kanoh, N.; Sone, S.
Reveromycin a inhibits osteolytic bone metastasis through an anti-osteoclastic activity Cancer Treat. Rev. 2005, 31, S41-S41.
Kawatani, M.; Woo, J. T.; Shinki, T.; Kanoh, N.; Osada, H.
Reveromycin A inhibits bone resorption in vitro and in vivo by inducing apoptosis specifically in osteoclasts Cancer Treat. Rev.2005, 31, S38-S38.
